Search Results - "Melki, R"

Alpha-synuclein and the prion hypothesis in Parkinson's disease by Melki, R.

“…Protein intracellular inclusions within the central nervous system are hallmarks of several progressive neurodegenerative disorders in man. The protein…”
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α-Synuclein strains cause distinct synucleinopathies after local and systemic administration by Peelaerts, W., Bousset, L., Van der Perren, A., Moskalyuk, A., Pulizzi, R., Giugliano, M., Van den Haute, C., Melki, R., Baekelandt, V.

“…Brain α-synuclein deposits are the hallmark of various distinct neurodegenerative diseases, and it is proposed that α-synuclein assemblies with different…”
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ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences by Peelaerts, W., Bousset, L., Baekelandt, V., Melki, R.

“…Several age-related neurodegenerative disorders are characterized by the deposition of aberrantly folded endogenous proteins. These proteins have prion-like…”
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Dangerousness assessment in psychiatric inpatients suffering from psychotic disorders by Khouadja, S., Melki, R., Taleb, C. Ben, Zarrouk, L.

“…Introduction Dangerousness is a state in which a person is likely to commit violent acts. Objectives Describe the socio-demographic and clinical…”
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Acute pancreatitis induced by valproic acid by Khouadja, S., Melki, R., Taleb, C. Ben, Zarrouk, L.

“…Introduction Valproic acid (VPA) is a commonly prescribed medication for epilepsy, migraine and especially bipolar disorder therapy. Although the common…”
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Psychiatric symptoms in neurofibromatosis type 2 by Khouadja, S., Melki, R., Younes, S., Zarrouk, L.

“…Introduction Neurofibromatosis type 2 (NF2) is a rare disorder associated with significant morbidity such as hearing loss that can lead to many psychiatric…”
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Exploring women’s sexuality during pregnancy: sociodemographic, culturel and relational characteristics by R Ben Soussia, Melki, R, H Ben Sassi, Bouali, W, Toumi, D, Zarrouk, L

“…IntroductionPregnancy is a period of important physical, psychological and hormonal changes. All these changes affect daily life, relationships with others,…”
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Pandemic COVID 19 and healthcare professionals: Mental health impact and depression by Ben Soussia, R., Melki, R., Aoun, M. H., Bouali, W., Zarrouk, L.

“…Introduction The SARS-COV2 pandemic represents a problematic and disruption of global health. Repeated exposure to stressful situations leads to increased…”
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Catatonia in patients with dementia by Khouadja, S., Taleb, C. Ben, Melki, R., Younes, S., Zarrouk, L.

“…Introduction Catatonia has been reported with almost all types of dementia but it remains under-diagnosed. Objectives Describe the characteristics of catatonia…”
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Alpha-synuclein aggregates are phosphatase resistant by Choi, S G, Tittle, T, Garcia-Prada, D, Kordower, J H, Melki, R, Killinger, B A

“…Alpha-synuclein (αsyn) is an intrinsically disordered protein that aggregates in the brain in several neurodegenerative diseases collectively called…”
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Binding, internalization and fate of Huntingtin Exon1 fibrillar assemblies in mitotic and nonmitotic neuroblastoma cells by Ruiz-Arlandis, G., Pieri, L., Bousset, L., Melki, R.

“…Aims The aggregation of Huntingtin (HTT) protein and of its moiety encoded by its Exon1 (HTTExon1) into fibrillar structures inside neurons is the molecular…”
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A Molecular Dynamics Approach to the Structural Characterization of Amyloid Aggregation by Cecchini, M., Curcio, R., Pappalardo, M., Melki, R., Caflisch, A.

“…A novel computational approach to the structural analysis of ordered β-aggregation is presented and validated on three known amyloidogenic polypeptides. The…”
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Protein aggregation and prionopathies by Renner, M., Melki, R.

“…Prion protein and prion-like proteins share a number of characteristics. From the molecular point of view, they are constitutive proteins that aggregate…”
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Identification and resolution of artifacts in bisulfite sequencing by Warnecke, Peter M, Stirzaker, Clare, Song, Jenny, Grunau, Christoph, Melki, John R, Clark, Susan J

“…Bisulfite sequencing has become the most widely used application to detect 5-methylcytosine (5-MeC) in DNA, and provides a reliable way of detecting any…”
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Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia by MELKI, J. R, VINCENT, P. C, CLARK, S. J

“…Hypermethylation in cancer often occurs in CpG islands that span the promoter regions of tumor suppressor genes. However, it is not clear if hypermethylation…”
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Improved detection of gastrointestinal pathogens using generalised sample processing and amplification panels by Siah, Shoo Peng, Merif, Juan, Kaur, Kiran, Nair, Jiny, Huntington, Peter G., Karagiannis, Thomas, Stark, Damien, Rawlinson, William, Olma, Tom, Thomas, Lee, Melki, John R., Millar, Douglas S.

“…We aimed to streamline the diagnosis of gastrointestinal disease by producing multiplexed real time polymerase chain reaction (PCR) panels employing universal…”
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CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma by Melki, R, Colomb, E, Lefort, N, Brézin, A P, Garchon, H-J

“…Introduction: Primary open-angle glaucoma (POAG) is a leading cause of visual impairment worldwide and a complex genetic disorder that affects mostly adults…”
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Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA by Warnecke, Peter M., Stirzaker, Clare, Melki, John R., Millar, Douglas S., Paul, Cheryl L., Clark, Susan J.

“…Methylation analysis of individual cytosines in genomic DNA can be determined quantitatively by bisulphite treatment and PCR amplification of the target DNA…”
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Structure of the Globular Region of the Prion Protein Ure2 from the Yeast Saccharomyces cerevisiae by Bousset, Luc, Belrhali, Hassan, Janin, Joël, Melki, Ronald, Morera, Solange

“…Background: The [URE3] non-Mendelian element of the yeast S. cerevisiae is due to the propagation of a transmissible form of the protein Ure2. The infectivity…”
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Hypermethylation of E-cadherin in leukemia by MELKI, J. R, VINCENT, P. C, BROWN, R. D, CLARK, S. J

“…E-cadherin gene is often termed a "metastasis suppressor" gene because the E-cadherin protein can suppress tumor cell invasion and metastasis. Inactivation of…”
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