Search Results - "Melita Vidaković"
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Synchrotron-based FTIR microspectroscopy reveals DNA methylation profile in DNA-HALO structure
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (05-12-2023)“…[Display omitted] •Synchrotron-based FTIR analysis reveals subtle changes in DNA methylation status.•Changes in DNA conformation lead to changes in IR…”
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From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
Published in Clinical epigenetics (25-03-2015)“…The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory…”
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TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation
Published in Epigenetics & chromatin (05-04-2022)“…Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to…”
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CXCL12 protects pancreatic β-cells from oxidative stress by a Nrf2-induced increase in catalase expression and activity
Published in Proceedings of the Japan Academy, Series B (2016)“…Due to intrinsically low levels of antioxidant enzyme expression and activity, insulin producing pancreatic β-cells are particularly susceptible to free…”
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β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms
Published in Journal of functional foods (01-01-2013)“…The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were…”
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PARP-1 Expression in the Mouse is Controlled by an Autoregulatory Loop: PARP-1 Binding to an Upstream S/MAR Element and to a Novel Recognition Motif in its Promoter Suppresses Transcription
Published in Journal of molecular biology (15-05-2009)“…This work identifies central components of a feedback mechanism for the expression of mouse poly(ADP-ribose) polymerase-1 (PARP-1). Using the stress-induced…”
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Alpha-lipoic acid preserves the structural and functional integrity of red blood cells by adjusting the redox disturbance and decreasing O-GlcNAc modifications of antioxidant enzymes and heat shock proteins in diabetic rats
Published in European journal of nutrition (01-12-2012)“…Purpose The aim of this study was to investigate whether the daily administration of α-lipoic acid (LA) during 4 weeks prevents the redox disturbance in red…”
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Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management
Published in Frontiers in endocrinology (Lausanne) (23-09-2022)“…The biggest drawback of a current diabetes therapy is the treatment of the consequences not the cause of the disease. Regardless of the diabetes type,…”
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DNA break repair: refined rules of an already complicated game
Published in Biochemistry and cell biology (01-06-2005)“…Of the many types of DNA-damage repair, this review concentrates on the aspects of DNA single- and double-strand break repair. Originally considered to…”
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Evaluation of the Antidiabetic Potential of Xanthone-Rich Extracts from Gentiana dinarica and Gentiana utriculosa
Published in International journal of molecular sciences (21-08-2024)“…Despite the existence of various therapeutic approaches, diabetes mellitus and its complications have been an increasing burden of mortality and disability…”
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Beneficial Effects of Probiotic Lactobacillus paraplantarum BGCG11 on Pancreatic and Duodenum Function in Diabetic Rats
Published in International journal of molecular sciences (13-07-2024)“…Diabetes mellitus, as a chronic metabolic disorder, significantly impacts the pancreas and among other organs, affects duodenal function. Emerging evidence…”
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DNA methylation of miR-200 clusters promotes epithelial to mesenchymal transition in human conjunctival epithelial cells
Published in Experimental eye research (01-08-2020)“…Epithelial to mesenchymal transition (EMT) contributes to fibrosis associated pathologies including scarring of different ocular tissues. Recently targeting…”
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Centaurium erythraea extract improves survival and functionality of pancreatic beta-cells in diabetes through multiple routes of action
Published in Journal of ethnopharmacology (05-10-2019)“…Centaurium erythraea Rafn (CE) is used as a traditional medicinal plant in Serbia to treat different ailments due to its antidiabetic, antipyretic,…”
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The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications
Published in Antioxidants (18-03-2021)“…Diabetes is a complex metabolic disorder resulting either from insulin resistance or an impaired insulin secretion. Prolonged elevated blood glucose…”
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Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin
Published in Pharmaceutics (13-06-2024)“…Silibinin has considerable therapeutic potential for the treatment of diabetes through anti-inflammatory, antioxidant, and immunomodulatory properties…”
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Centaurium erythraea methanol extract improves the functionality of diabetic liver and kidney by mitigating hyperglycemia-induced oxidative stress
Published in Journal of functional foods (01-03-2022)“…[Display omitted] •Persistent oxidative stress leads to the development of diabetic complications.•Centaurium erythraea extract (CEE) reduced protein…”
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EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells
Published in Frontiers in endocrinology (Lausanne) (16-03-2023)“…Beta cell dysfunction by loss of beta cell identity, dedifferentiation, and the presence of polyhormonal cells are main characteristics of diabetes. The…”
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Oral administration of probiotic Lactobacillus paraplantarum BGCG11 attenuates diabetes-induced liver and kidney damage in rats
Published in Journal of functional foods (01-11-2017)“…•Probiotic Lactobacillus paraplantarum BGCG11 showed decreased hyperglycemia in diabetic rats.•The probiotic treatment adjusted the diabetes-induced redox…”
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The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level
Published in Journal of fungi (Basel) (16-01-2021)“…Diabetes mellitus is a life-threatening multifactorial metabolic disorder characterized by high level of glucose in the blood. Diabetes and its chronic…”
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