Search Results - "Melissa Bowerman"

Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases by Bowerman, Melissa

“…Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), severely impact the function of neuronal…”
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Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy by Hammond, Suzan M., Hazell, Gareth, Shabanpoor, Fazel, Saleh, Amer F., Bowerman, Melissa, Sleigh, James N., Meijboom, Katharina E., Zhou, Haiyan, Muntoni, Francesco, Talbot, Kevin, Gait, Michael J., Wood, Matthew J. A.

“…The development of antisense oligonucleotide therapy is an important advance in the identification of corrective therapy for neuromuscular diseases, such as…”
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Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy by Bowerman, Melissa, Murray, Lyndsay M, Boyer, Justin G, Anderson, Carrie L, Kothary, Rashmi

“…Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. It is caused by mutations/deletions of the survival motor neuron 1 (SMN1) gene and…”
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Therapeutic strategies for spinal muscular atrophy: SMN and beyond by Bowerman, Melissa, Becker, Catherina G, Yáñez-Muñoz, Rafael J, Ning, Ke, Wood, Matthew J A, Gillingwater, Thomas H, Talbot, Kevin

“…Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder characterized by loss of motor neurons and muscle atrophy, generally presenting in…”
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Spinal muscular atrophy: antisense oligonucleotide therapy opens the door to an integrated therapeutic landscape by Wood, Matthew J.A., Talbot, Kevin, Bowerman, Melissa

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Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth by Salim Benlefki, Richard Younes, Désiré Challuau, Nathalie Bernard-Marissal, Cécile Hilaire, Frédérique Scamps, Melissa Bowerman, Rashmi Kothary, Bernard L. Schneider, Cedric Raoul

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The cross-linguistic categorization of everyday events: A study of cutting and breaking by Majid, Asifa, Boster, James S., Bowerman, Melissa

“…The cross-linguistic investigation of semantic categories has a long history, spanning many disciplines and covering many domains. But the extent to which…”
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Can language restructure cognition? The case for space by Majid, Asifa, Bowerman, Melissa, Kita, Sotaro, Haun, Daniel B.M., Levinson, Stephen C.

“…Frames of reference are coordinate systems used to compute and specify the location of objects with respect to other objects. These have long been thought of…”
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Abnormal fatty acid metabolism is a core component of spinal muscular atrophy by Deguise, Marc‐Olivier, Baranello, Giovanni, Mastella, Chiara, Beauvais, Ariane, Michaud, Jean, Leone, Alessandro, De Amicis, Ramona, Battezzati, Alberto, Dunham, Christopher, Selby, Kathryn, Warman Chardon, Jodi, McMillan, Hugh J., Huang, Yu‐Ting, Courtney, Natalie L., Mole, Alannah J., Kubinski, Sabrina, Claus, Peter, Murray, Lyndsay M., Bowerman, Melissa, Gillingwater, Thomas H., Bertoli, Simona, Parson, Simon H., Kothary, Rashmi

“…Objective Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder leading to paralysis and subsequent death in young children. Initially…”
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The Relationship between Body Composition, Fatty Acid Metabolism and Diet in Spinal Muscular Atrophy by Watson, Katherine S, Boukhloufi, Imane, Bowerman, Melissa, Parson, Simon H

“…Spinal muscular atrophy (SMA) is an autosomal recessive condition that results in pathological deficiency of the survival motor neuron (SMN) protein. SMA most…”
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Targeting the 5′ untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy by Winkelsas, Audrey M., Grunseich, Christopher, Harmison, George G., Chwalenia, Katarzyna, Rinaldi, Carlo, Hammond, Suzan M., Johnson, Kory, Bowerman, Melissa, Arya, Sukrat, Talbot, Kevin, Wood, Matthew J., Fischbeck, Kenneth H.

“…Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene. All patients have at least one copy…”
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Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice by Meijboom, Katharina E., Sutton, Emma R., McCallion, Eve, McFall, Emily, Anthony, Daniel, Edwards, Benjamin, Kubinski, Sabrina, Tapken, Ines, Bünermann, Ines, Hazell, Gareth, Ahlskog, Nina, Claus, Peter, Davies, Kay E., Kothary, Rashmi, Wood, Matthew J. A., Bowerman, Melissa

“…Abstract Background Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is…”
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An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides by Selvakumaran, Jamuna, Ursu, Simona, Bowerman, Melissa, Lu-Nguyen, Ngoc, Wood, Matthew J., Malerba, Alberto, Yáñez-Muñoz, Rafael J.

“…The blood–brain barrier (BBB) is the specialised microvasculature system that shields the central nervous system (CNS) from potentially toxic agents. Attempts…”
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KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects by Bowerman, Melissa, Salsac, Céline, Bernard, Véronique, Soulard, Claire, Dionne, Annie, Coque, Emmanuelle, Benlefki, Salim, Hince, Pascale, Dion, Patrick A, Butler-Browne, Gillian, Camu, William, Bouchard, Jean-Pierre, Delpire, Eric, Rouleau, Guy A, Raoul, Cédric, Scamps, Frédérique

“…Abstract Loss-of-function mutations in the potassium-chloride cotransporter KCC3 lead to Andermann syndrome, a severe sensorimotor neuropathy characterized by…”
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Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice by Walter, Lisa M., Deguise, Marc-Olivier, Meijboom, Katharina E., Betts, Corinne A., Ahlskog, Nina, van Westering, Tirsa L.E., Hazell, Gareth, McFall, Emily, Kordala, Anna, Hammond, Suzan M., Abendroth, Frank, Murray, Lyndsay M., Shorrock, Hannah K., Prosdocimo, Domenick A., Haldar, Saptarsi M., Jain, Mukesh K., Gillingwater, Thomas H., Claus, Peter, Kothary, Rashmi, Wood, Matthew J.A., Bowerman, Melissa

“…The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose…”
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Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy by Meijboom, Katharina E, Volpato, Viola, Monzón-Sandoval, Jimena, Hoolachan, Joseph M, Hammond, Suzan M, Abendroth, Frank, de Jong, Olivier G, Hazell, Gareth, Ahlskog, Nina, Wood, Matthew Ja, Webber, Caleb, Bowerman, Melissa

“…Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are…”
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Multi-Study Proteomic and Bioinformatic Identification of Molecular Overlap between Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA) by Šoltić, Darija, Bowerman, Melissa, Stock, Joanne, Shorrock, Hannah K, Gillingwater, Thomas H, Fuller, Heidi R

“…Unravelling the complex molecular pathways responsible for motor neuron degeneration in amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA)…”
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A Single Amino Acid Residue Regulates PTEN-Binding and Stability of the Spinal Muscular Atrophy Protein SMN by Rademacher, Sebastian, Detering, Nora T, Schüning, Tobias, Lindner, Robert, Santonicola, Pamela, Wefel, Inga-Maria, Dehus, Janina, Walter, Lisa M, Brinkmann, Hella, Niewienda, Agathe, Janek, Katharina, Varela, Miguel A, Bowerman, Melissa, Di Schiavi, Elia, Claus, Peter

“…Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by decreased levels of the survival of motoneuron (SMN) protein. Post-translational mechanisms…”
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Learning to express motion events in English and Korean: the influence of language-specific lexicalization patterns by Choi, S, Bowerman, M

“…English and Korean differ in how they lexicalize the components of motion events. English characteristically conflates Motion with Manner, Cause, or Deixis,…”
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Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model by Bowerman, Mélissa, Beauvais, Ariane, Anderson, Carrie L., Kothary, Rashmi

“…Spinal muscular atrophy (SMA) is an inherited disease resulting in the highest mortality of children under the age of two. SMA is caused by mutations or…”
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