Search Results - "Melissa, Heffler"

Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy by Heffler, Melissa, Golubovskaya, Vita M, Dunn, Kelli M Bullard, Cance, William

“…Focal adhesion kinase (FAK) increasingly has been implicated in cancer growth and progression. 1,2,4,5-Benzenetetraamine tetrahydrochloride (Y15) is a small…”
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Evolving therapies and FAK inhibitors for the treatment of cancer by Dunn, Kelli Bullard, Heffler, Melissa, Golubovskaya, Vita M

“…Despite advances in medical and surgical therapy, cancer kills more than half a million people in the United States annually, and the majority of these…”
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Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15 by Golubovskaya, Vita, O’Brien, Shalana, Ho, Baotran, Heffler, Melissa, Conroy, Jeffrey, Hu, Quang, Wang, Dan, Liu, Song, Cance, William G.

“…Purpose Focal adhesion kinase is an important survival signal in cancer. Recently, we demonstrated that the autophosphorylation inhibitor of FAK, Y15,…”
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Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth by increasing apoptosis by Teng, Brian P, Heffler, Melissa D, Lai, Eric C, Zhao, Ya-Li, LeVea, Charles M, Golubovskaya, Vita M, Bullarddunn, Kelli M

“…Hyaluronan (HA) and hyaluronan synthases (HAS) have been implicated in cancer growth and progression. We previously have shown that HAS3 and HA mediate tumor…”
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FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes by Heffler, Melissa, Golubovskaya, Vita M, Conroy, Jeffrey, Liu, Song, Wang, Dan, Cance, William G, Dunn, Kelli B

“…Focal adhesion kinase (FAK), hyaluronan (HA), and hyaluronan synthase-3 (HAS3) have been implicated in cancer growth and progression. FAK inhibition with the…”
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Abstract A51: Cancer stem cell marker ALDH1A3 is associated with increased resistance of Lovo-1 colon cancer cells to autophosphorylation inhibitor of FAK by Ho, Baotran, Heffler, Melissa, Conroy, Jeffrey, Song, Liu, Wang, Dan, Cance, William G., Golubovskaya, Vita M.

“…Introduction: Focal Adhesion Kinase is an important survival signal in cancer. Recently, we demonstrated that the autophosphorylation inhibitor of FAK, Y15…”
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Abstract C184: A small molecule FAK inhibitor increases the cytotoxicity of 5-fluorouracil by Melissa, Heffler, Golubovskaya, Vita M., Cance, William G., Dunn, Kelli M. Bullard

“…Introduction: Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that has been implicated in colon cancer progression. We have shown that SW620 colon…”
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