Search Results - "Meling, Gunn I"

Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas by Lind, Guro E, Danielsen, Stine A, Ahlquist, Terje, Merok, Marianne A, Andresen, Kim, Skotheim, Rolf I, Hektoen, Merete, Rognum, Torleiv O, Meling, Gunn I, Hoff, Geir, Bretthauer, Michael, Thiis-Evensen, Espen, Nesbakken, Arild, Lothe, Ragnhild A

“…The presence of cancer-specific DNA methylation patterns in epithelial colorectal cells in human feces provides the prospect of a simple, non-invasive…”
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Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers by Ahlquist, Terje, Lind, Guro E, Costa, Vera L, Meling, Gunn I, Vatn, Morten, Hoff, Geir S, Rognum, Torleiv O, Skotheim, Rolf I, Thiis-Evensen, Espen, Lothe, Ragnhild A

“…Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact. This study aims to pinpoint epigenetic…”
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A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines by Lind, Guro E, Thorstensen, Lin, Løvig, Tone, Meling, Gunn I, Hamelin, Richard, Rognum, Torleiv O, Esteller, Manel, Lothe, Ragnhild A

“…Tumor cell lines are commonly used as experimental tools in cancer research, but their relevance for the in vivo situation is debated. In a series of 11…”
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Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses by Kleivi, Kristine, Lind, Guro E, Diep, Chieu B, Meling, Gunn I, Brandal, Lin T, Nesland, Jahn M, Myklebost, Ola, Rognum, Torleiv O, Giercksky, Karl-Erik, Skotheim, Rolf I, Lothe, Ragnhild A

“…Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced…”
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Genetic and Epigenetic Changes of Components Affecting the WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability by Thorstensen, Lin, Lind, Guro E., Løvig, Tone, Diep, Chieu B., Meling, Gunn I., Rognum, Torleiv O., Lothe, Ragnhild A.

“…An unselected series of 310 colorectal carcinomas, stratified according to microsatellite instability (MSI) and DNA ploidy, was examined for mutations and/or…”
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ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis by Lind, Guro E, Kleivi, Kristine, Meling, Gunn I, Teixeira, Manuel R, Thiis-Evensen, Espen, Rognum, Torleiv O, Lothe, Ragnhild A

“…Gene silencing through CpG island hypermethylation is a major mechanism in cancer development. In the present study, we aimed to identify and validate novel…”
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Hypermethylated MAL gene - a silent marker of early colon tumorigenesis by Lind, Guro E, Ahlquist, Terje, Kolberg, Matthias, Berg, Marianne, Eknaes, Mette, Alonso, Miguel A, Kallioniemi, Anne, Meling, Gunn I, Skotheim, Rolf I, Rognum, Torleiv O, Thiis-Evensen, Espen, Lothe, Ragnhild A

“…Tumor-derived aberrantly methylated DNA might serve as diagnostic biomarkers for cancer, but so far, few such markers have been identified. The aim of the…”
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RAS Signaling in Colorectal Carcinomas through Alteration of RAS, RAF, NF1, and/or RASSF1A by Ahlquist, Terje, Bottillo, Irene, Danielsen, Stine A., Meling, Gunn I., Rognum, Torleiv O., Lind, Guro E., Dallapiccola, Bruno, Lothe, Ragnhild A.

“…More than half of all colorectal carcinomas are known to exhibit an activated mitogen-activated protein kinase pathway. The NF1 gene, a negative regulator of…”
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Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status by Danielsen, Stine A, Lind, Guro E, Bjørnslett, Merete, Meling, Gunn I, Rognum, Torleiv O, Heim, Sverre, Lothe, Ragnhild A

“…PTEN regulates cell homeostasis by inhibiting growth signals transduced through PI3-kinases. The gene is mutated in several cancer types, but so far, only a…”
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Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status by Danielsen, Stine A., Lind, Guro E., Bjørnslett, Merete, Meling, Gunn I., Rognum, Torleiv O., Heim, Sverre, Lothe, Ragnhild A.

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M1985 Potential Cancer Prevention Markers Can Be Identified By Comparing Gene Methylation Pattern in Normal Colon Mucosa to Those of Benign and Malignant Tumours by Ahlquist, Terje, Thiis-Evensen, Espen, Lind, Guro E, Meling, Gunn I, Vatn, Morten H, Hoff, Geir S, Rognum, Torleiv O, Lothe, Ragnhild A

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RAS signaling in colorectal carcinomas through alterations of RAS, RAF, NF1 and/or RASSF1A by Ahlquist, T, Bottillo, I, Danielsen, SA, Meling, GI, Rognum, TO, Lind, GE, Dallapiccola, B, Lothe, R A

“…More than half of all colorectal carcinomas are known to exhibit an activated MAPK (mitogen-activated protein kinase) pathway. The NF1 gene, a negative…”
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RAS Signaling in Colorectal Carcinomas through Alteration of RAS, RAF, NF1, and/or RASSF1A1 by Ahlquist, Terje, Bottillo, Irene, Danielsen, Stine A, Meling, Gunn I, Rognum, Torleiv O, Lind, Guro E, Dallapiccola, Bruno, Lothe, Ragnhild A

“…More than half of all colorectal carcinomas are known to exhibit an activated mitogen-activated protein kinase pathway. The NF1 gene, a negative regulator of…”
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WNT1 inducible signaling pathway protein 3, WISP-3, a novel target gene in colorectal carcinomas with microsatellite instability by Thorstensen, Lin, Diep, Chieu B., Meling, Gunn I., Aagesen, Trude H., Ahrens, Christian H., Rognum, Torleiv O., Lothe, Ragnhild A.

“…Microsatellite instability (MSI) is the phenotype of colorectal carcinomas with defect mismatch repair. Genes with repetitive sequences within their coding…”
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TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival by Børresen-Dale, A L, Lothe, R A, Meling, G I, Hainaut, P, Rognum, T O, Skovlund, E

“…In a consecutive series of 222 colorectal carcinomas from patients with a median follow-up time of 56.8 months (range, 0.5-92.2) treated with surgery, the TP53…”
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Genetic and Epigenetic Changes of Components Affecting the WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability1 by Thorstensen, Lin, Lind, Guro E, Løvig, Tone, Diep, Chieu B, Meling, Gunn I, Rognum, Torleiv O, Lothe, Ragnhild A

“…An unselected series of 310 colorectal carcinomas, stratified according to microsatellite instability (MSI) and DNA ploidy, was examined for mutations and/or…”
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WNT1 inducible signaling pathway protein 3, WISP-3, a novel target gene in colorectal carcinomas with microsatellite instability. Editorial by THORSTENSEN, Lin, DIEP, Chieu B, MELING, Gunn I, AAGESEN, Trude H, AHRENS, Christian H, ROGNUM, Torleiv O, LOTHE, Ragnhild A, GOEL, Ajay, ARNOLD, Christian N, BOLAND, C. Richard

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Near diploid large bowel carcinomas have better five-year survival than aneuploid ones by Rognum, T O, Lund, E, Meling, G I, Langmark, F

“…One hundred patients who underwent surgery for large bowel carcinoma between 1978 and 1982 were examined by flow cytometric DNA quantitation of fresh tumor…”
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