Search Results - "Melguizo Sanchis, Dario"

ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export by Malla, Sandhya, Prasad Bhattarai, Devi, Groza, Paula, Melguizo‐Sanchis, Dario, Atanasoai, Ionut, Martinez‐Gamero, Carlos, Román, Ángel‐Carlos, Zhu, Dandan, Lee, Dung‐Fang, Kutter, Claudia, Aguilo, Francesca

“…The pluripotent state is not solely governed by the action of the core transcription factors OCT4, SOX2, and NANOG, but also by a series of co‐transcriptional…”
Get full text

Pluripotent Stem Cell‐Derived Hematopoietic Progenitors Are Unable to Downregulate Key Epithelial‐Mesenchymal Transition‐Associated miRNAs by Meader, Ellie, Barta, Tomas, Melguizo‐Sanchis, Dario, Tilgner, Katarzyna, Montaner, David, El‐Harouni, Ashraf A., Armstrong, Lyle, Lako, Majlinda

“…Hematopoietic stem cells derived from pluripotent stem cells could be used as an alternative to bone marrow transplants. Deriving these has been a long‐term…”
Get full text

The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages by Zhu, Lili, Gomez-Duran, Aurora, Saretzki, Gabriele, Jin, Shibo, Tilgner, Katarzyna, Melguizo-Sanchis, Dario, Anyfantis, Georgios, Al-Aama, Jumana, Vallier, Ludovic, Chinnery, Patrick, Lako, Majlinda, Armstrong, Lyle

“…Human induced pluripotent stem cell (hiPSC) utility is limited by variations in the ability of these cells to undergo lineage-specific differentiation. We have…”
Get full text

Concise Review: Getting to the Core of Inherited Bone Marrow Failures by Adam, Soheir, Melguizo Sanchis, Dario, El‐Kamah, Ghada, Samarasinghe, Sujith, Alharthi, Sameer, Armstrong, Lyle, Lako, Majlinda

“…Bone marrow failure syndromes (BMFS) are a group of disorders with complex pathophysiology characterized by a common phenotype of peripheral cytopenia and/or…”
Get full text

Steering pluripotency and differentiation with N6-methyladenosine RNA modification by Malla, Sandhya, Melguizo-Sanchis, Dario, Aguilo, Francesca

“…Chemical modifications of RNA provide a direct and rapid way to modulate the existing transcriptome, allowing the cells to adapt rapidly to the changing…”
Get full text

Steering pluripotency and differentiation with N 6 -methyladenosine RNA modification by Malla, Sandhya, Melguizo-Sanchis, Dario, Aguilo, Francesca

“…Chemical modifications of RNA provide a direct and rapid way to modulate the existing transcriptome, allowing the cells to adapt rapidly to the changing…”
Get full text

Towards germline gene therapy of inherited mitochondrial diseases by Tachibana, Masahito, Amato, Paula, Sparman, Michelle, Woodward, Joy, Sanchis, Dario Melguizo, Ma, Hong, Gutierrez, Nuria Marti, Tippner-Hedges, Rebecca, Kang, Eunju, Lee, Hyo-Sang, Ramsey, Cathy, Masterson, Keith, Battaglia, David, Lee, David, Wu, Diana, Jensen, Jeffrey, Patton, Phillip, Gokhale, Sumita, Stouffer, Richard, Mitalipov, Shoukhrat

“…Mutations in mitochondrial DNA (mtDNA) are associated with severe human diseases and are maternally inherited through the egg’s cytoplasm. Here we investigated…”
Get full text

iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors by Melguizo-Sanchis, Dario, Xu, Yaobo, Taheem, Dheraj, Yu, Min, Tilgner, Katarzyna, Barta, Tomas, Gassner, Katja, Anyfantis, George, Wan, Tengfei, Elango, Ramu, Alharthi, Sameer, El-Harouni, Ashraf A., Przyborski, Stefan, Adam, Soheir, Saretzki, Gabriele, Samarasinghe, Sujith, Armstrong, Lyle, Lako, Majlinda

“…Aplastic Anemia (AA) is a bone marrow failure (BMF) disorder, resulting in bone marrow hypocellularity and peripheral pancytopenia. Severe aplastic anemia…”
Get full text

Modelling severe paediatric aplastic anaemia using induced pluripotent stem cell technology by Melguizo Sanchis, Dario

“…Aplastic anaemia (AA) is a disorder resulting in pancytopenia and hypocellular bone marrow. Although the immunological nature of AA pathogenesis is widely…”
Get full text

Characterisation of human embryonic stem cells conditioning media by 1H-nuclear magnetic resonance spectroscopy by MacIntyre, David A, Melguizo Sanchís, Darío, Jiménez, Beatriz, Moreno, Rubén, Stojkovic, Miodrag, Pineda-Lucena, Antonio

“…Cell culture media conditioned by human foreskin fibroblasts (HFFs) provide a complex supplement of protein and metabolic factors that support in vitro…”
Get full text

Characterisation of Human Embryonic Stem Cells Conditioning Media by .sup.1H-Nuclear Magnetic Resonance Spectroscopy by MacIntyre, David A, Melguizo Sanchís, Darío, Jiménez, Beatriz, Moreno, Rubén, Stojkovic, Miodrag, Pineda-Lucena, Antonio

“…Background Cell culture media conditioned by human foreskin fibroblasts (HFFs) provide a complex supplement of protein and metabolic factors that support in…”
Get full text