Search Results - "Melero Fernández de Mera, Raquel M."

Nitration of Hsp90 induces cell death by Franco, Maria Clara, Ye, Yaozu, Refakis, Christian A., Feldman, Jessica L., Stokes, Audrey L., Basso, Manuela, Melero Fernández de Mera, Raquel M., Sparrow, Nicklaus A., Calingasan, Noel Y., Kiaei, Mahmoud, Rhoads, Timothy W., Ma, Thong C., Grumet, Martin, Barnes, Stephen, Beal, M. Flint, Beckman, Joseph S., Mehl, Ryan, Estévez, Alvaro G.

“…Oxidative stress is a widely recognized cause of cell death associated with neurodegeneration, inflammation, and aging. Tyrosine nitration in these conditions…”
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CD44 Modulates Cell Migration and Invasion in Ewing Sarcoma Cells by Fernández-Tabanera, Enrique, García-García, Laura, Rodríguez-Martín, Carlos, Cervera, Saint T, González-González, Laura, Robledo, Cristina, Josa, Santiago, Martínez, Selene, Chapado, Luis, Monzón, Sara, Melero-Fernández de Mera, Raquel M, Alonso, Javier

“…The chimeric EWSR1::FLI1 transcription factor is the main oncogenic event in Ewing sarcoma. Recently, it has been proposed that EWSR1::FLI1 levels can…”
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Therapeutic Potential of EWSR1–FLI1 Inactivation by CRISPR/Cas9 in Ewing Sarcoma by Cervera, Saint T., Rodríguez-Martín, Carlos, Fernández-Tabanera, Enrique, Melero-Fernández de Mera, Raquel M., Morin, Matias, Fernández-Peñalver, Sergio, Iranzo-Martínez, Maria, Amhih-Cardenas, Jorge, García-García, Laura, González-González, Laura, Moreno-Pelayo, Miguel Angel, Alonso, Javier

“…Ewing sarcoma is an aggressive bone cancer affecting children and young adults. The main molecular hallmark of Ewing sarcoma are chromosomal translocations…”
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CD44 In Sarcomas: A Comprehensive Review and Future Perspectives by Fernández-Tabanera, Enrique, Melero-Fernández de Mera, Raquel M., Alonso, Javier

“…It is widely accepted that the tumor microenvironment, particularly the extracellular matrix, plays an essential role in the development of tumors through the…”
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The Transcription Factor FEZF1 , a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes by García-García, Laura, Fernández-Tabanera, Enrique, Cervera, Saint T, Melero-Fernández de Mera, Raquel M, Josa, Santiago, González-González, Laura, Rodríguez-Martín, Carlos, Grünewald, Thomas G P, Alonso, Javier

“…Ewing sarcoma is a rare pediatric tumor characterized by chromosomal translocations that give rise to aberrant chimeric transcription factors (e.g.,…”
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Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone by Perez-Alvarez, Sergio, Solesio, Maria E., Cuenca-Lopez, Maria D., Melero-Fernández de Mera, Raquel M., Villalobos, Carlos, Kmita, Hanna, Galindo, Maria F., Jordán Bueso, Joaquín

“…Previously, we have shown that SH-SY5Y cells exposed to high concentrations of methadone died due to a necrotic-like cell death mechanism related to delayed…”
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Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models by Li, Li-Li, Melero-Fernandez de Mera, Raquel M, Chen, Jia, Ba, Wei, Kasri, Nael Nadif, Zhang, Mingjie, Courtney, Michael J

“…The protein NOS1AP/CAPON mediates signaling from a protein complex of NMDA receptor, PSD95 and nNOS. The only stroke trial for neuroprotectants that showed…”
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A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs by Melero-Fernandez de Mera, Raquel M., Li, Li-Li, Popinigis, Arkadiusz, Cisek, Katryna, Tuittila, Minna, Yadav, Leena, Serva, Andrius, Courtney, Michael J.

“…Engineering light-sensitive protein regulators has been a tremendous multidisciplinary challenge. Optogenetic regulators of MAPKs, central nodes of cellular…”
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BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis by Xènia Garrofé-Ochoa, Raquel M. Melero-Fernández de Mera, Franciso J. Fernández-Gómez, Judit Ribas, Joaquín Jordán, Jacint Boix

“…In previous reports, we have shown in SH-SY5 cells that olomoucine and roscovitine, two inhibitory drugs of cyclin-dependent kinases, caused apoptosis…”
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Ceramide Composition in Exosomes for Characterization of Glioblastoma Stem-Like Cell Phenotypes by Melero-Fernandez de Mera, Raquel M, Villaseñor, Alma, Rojo, David, Carrión-Navarro, Josefa, Gradillas, Ana, Ayuso-Sacido, Angel, Barbas, Coral

“…Glioblastoma (GBM) is one of the most malignant central nervous system tumor types. Comparative analysis of GBM tissues has rendered four major molecular…”
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Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis by Perez-Alvarez, Sergio, Cuenca-Lopez, Maria D., de Mera, Raquel M. Melero-Fernández, Puerta, Elena, Karachitos, Andonis, Bednarczyk, Piotr, Kmita, Hanna, Aguirre, Norberto, Galindo, Maria F, Jordán, Joaquin

“…Methadone is a widely used therapeutic opioid in narcotic addiction and neuropathic pain syndromes. Oncologists regularly use methadone as a long-lasting…”
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The senescence-accelerated mouse (SAM-P8) as a model for the study of vascular functional alterations during aging by Lloréns, Silvia, de Mera, Raquel M Melero-Fernandez, Pascual, Alejandro, Prieto-Martín, Ana, Mendizábal, Yolanda, de Cabo, Carlos, Nava, Eduardo, Jordán, Joaquín

“…We studied vascular function in quiescent aortas from senescence-accelerated resistant (SAM-R1) and prone (SAM-P8) mice. Myographical studies of thoracic aorta…”
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The senescence-accelerated mouse (SAM-P8) as a model for the study of vascular functional alterations during aging by LLORENS, Silvia, MELERO-FERNANDEZ DE MERA, Raquel M, PASCUAL, Alejandro, PRIETO-MARTIN, Ana, MENDIZABAL, Yolanda, DE CABO, Carlos, NAVA, Eduardo, JORDAN, Joaquin

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Nitration of Hsp90 induces cell death by Franco, Maria Clara, Ye, Yaozu, Refakis, Christian A., Feldman, Jessica L., Stokes, Audrey L., Basso, Manuela, de Mera, Raquel M. Melero Fernández, Sparrow, Nicklaus A., Calingasan, Noel Y., Kiaei, Mahmoud, Rhoads, Timothy W., Ma, Thong C., Grumet, Martin, Barnes, Stephen, Beal, M. Flint, Beckman, Joseph S., Mehl, Ryan, Estévez, Alvaro G.

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Es la vieja minociclina un nuevo fármaco neuroprotector? by Melero Fernández de Mera, Raquel M., García Martínez, Eva, Fernández Gómez, Francisco José, Hernández Guijo, Jesús M., Aguirre, Norberto, Galindo Anaya, María F., Jordán Bueso, Joaquín

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