Search Results - "Melero, Maite"

Role of FoxP3 + Regulatory T Cells in Modulating Immune Responses to Adeno-Associated Virus Gene Therapy by Muñoz-Melero, Maite, Biswas, Moanaro

“…Adeno-associated virus (AAV) gene therapy is making rapid strides owing to its wide range of therapeutic applications. However, development of serious immune…”
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Oral tolerance to prevent anti-drug antibody formation in protein replacement therapies by Rana, Jyoti, Muñoz, Maite Melero, Biswas, Moanaro

“…•Anti-drug antibodies (ADA) complicate protein replacement therapy for monogenic disorders.•Antigen based oral tolerance induction can prevent the formation of…”
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Characterization of a Bioengineered AAV3B Capsid Variant with Enhanced Hepatocyte Tropism and Immune Evasion by Rana, Jyoti, Marsic, Damien, Zou, Chenhui, Muñoz-Melero, Maite, Li, Xin, Kondratov, Oleksandr, Li, Ning, de Jong, Ype P, Zolotukhin, Sergei, Biswas, Moanaro

“…Capsid engineering of adeno-associated virus (AAV) can surmount current limitations to gene therapy such as broad tissue tropism, low transduction efficiency,…”
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CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII by Rana, Jyoti, Perry, Daniel J., Kumar, Sandeep R.P., Muñoz-Melero, Maite, Saboungi, Rania, Brusko, Todd M., Biswas, Moanaro

“…Regulatory T cells (Tregs) control immune responses in autoimmune disease, transplantation, and enable antigen-specific tolerance induction in…”
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Lifestyle Modification Improves Insulin Resistance and Carotid Intima‐Media Thickness in a Metabolically Healthy Obese Prepubescent Population by Gallardo‐Escribano, Cristina, Vargas‐Candela, Antonio, Vilches‐Perez, Alberto, Muñoz‐Melero, Maite, Ruiz‐Moreno, M. Isabel, Benitez‐Porres, Javier, Romance‐Garcia, Angel Ramon, Rodriguez‐Ortega, Rocío, Rosa‐López, Andrés, Rosales‐Jaime, Antonio, Diaz‐Ruiz, Juan, Tinahones, Francisco J., Gómez‐Huelgas, Ricardo, Bernal‐Lopez, M. Rosa

“…ABSTRACT Objectives: The aim of this study was to analyze effects of a 12‐month lifestyle modification that involved a Mediterranean diet (MedDiet) and…”
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TLR9-independent CD8 + T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling by Kumar, Sandeep R P, Biswas, Moanaro, Cao, Di, Arisa, Sreevani, Muñoz-Melero, Maite, Lam, Anh K, Piñeros, Annie R, Kapur, Reuben, Kaisho, Tsuneyasu, Kaufman, Randal J, Xiao, Weidong, Shayakhmetov, Dmitry M, Terhorst, Cox, de Jong, Ype P, Herzog, Roland W

“…Upon viral infection of the liver, CD8 T cell responses may be triggered despite the immune suppressive properties that manifest in this organ. We sought to…”
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Distinct functions and transcriptional signatures in orally induced regulatory T cell populations by Biswas, Moanaro, So, Kaman, Bertolini, Thais B, Krishnan, Preethi, Rana, Jyoti, Muñoz-Melero, Maite, Syed, Farooq, Kumar, Sandeep R P, Gao, Hongyu, Xuei, Xiaoling, Terhorst, Cox, Daniell, Henry, Cao, Sha, Herzog, Roland W

“…Oral administration of antigen induces regulatory T cells (Treg) that can not only control local immune responses in the small intestine, but also traffic to…”
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B cell focused transient immune suppression protocol for efficient AAV readministration to the liver by Rana, Jyoti, Herzog, Roland W., Muñoz-Melero, Maite, Yamada, Kentaro, Kumar, Sandeep R.P., Lam, Anh K., Markusic, David M., Duan, Dongsheng, Terhorst, Cox, Byrne, Barry J., Corti, Manuela, Biswas, Moanaro

“…Adeno-associated virus (AAV) vectors are used for correcting multiple genetic disorders. Although the goal is to achieve lifelong correction with a single…”
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EL FUTUR DE LES LLENGÜES EN L'ERA DIGITAL: OPORTUNITATS I BRETXA LINGÜÍSTICA by Melero, Maite

“…En aquest article reflexionem sobre com impactarà la revolució digital en la supervivència de les llengües en un futur no gaire llunyà. Si una cosa tenim clara…”
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Viral Vector Based Immunotherapy for Peanut Allergy by Gonzalez-Visiedo, Miguel, Herzog, Roland W, Munoz-Melero, Maite, Blessinger, Sophia A, Cook-Mills, Joan M, Daniell, Henry, Markusic, David M

“…Food allergy (FA) is estimated to impact up to 10% of the population and is a growing health concern. FA results from a failure in the mucosal immune system to…”
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Redundancy in Innate Immune Pathways That Promote CD8 + T-Cell Responses in AAV1 Muscle Gene Transfer by Li, Ning, Kumar, Sandeep R P, Cao, Di, Munoz-Melero, Maite, Arisa, Sreevani, Brian, Bridget A, Greenwood, Calista M, Yamada, Kentaro, Duan, Dongsheng, Herzog, Roland W

“…While adeno-associated viral (AAV) vectors are successfully used in a variety of in vivo gene therapy applications, they continue to be hampered by the immune…”
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Single-dose AAV vector gene immunotherapy to treat food allergy by Gonzalez-Visiedo, Miguel, Li, Xin, Munoz-Melero, Maite, Kulis, Michael D., Daniell, Henry, Markusic, David M.

“…Immunotherapies for patients with food allergy have shown some success in limiting allergic responses. However, these approaches require lengthy protocols with…”
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Factor VIII trafficking to CD4+ T cells shapes its immunogenicity and requires several types of antigen-presenting cells by Kaczmarek, Radoslaw, Piñeros, Annie R., Patterson, Paige E., Bertolini, Thais B., Perrin, George Q., Sherman, Alexandra, Born, Jameson, Arisa, Sreevani, Arvin, Matthew C., Kamocka, Malgorzata M., Martinez, Michelle M., Dunn, Kenneth W., Quinn, Sean M., Morris, Johnathan J., Wilhelm, Amelia R., Kaisho, Tsuneyasu, Munoz-Melero, Maite, Biswas, Moanaro, Kaplan, Mark H., Linnemann, Amelia K., George, Lindsey A., Camire, Rodney M., Herzog, Roland W.

“…•Helper T-cell response to coagulation factor VIII critically depends on a select set of anatomically distinct antigen-presenting cells.•Innate immune…”
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Converses al voltant de la intel·ligència artificial en clau catalana by Marta R. Costa-Jussà, Maite Melero Nogués

“…La intel·ligència artificial mou milions d’euros i ocupa una part important de les agendes polítiques i estratègiques dels governs. En aquest article…”
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The Strategic impact of META-NET on the regional, national and international level by Rehm, Georg, Uszkoreit, Hans, Ananiadou, Sophia, Bel, Núria, Bielevičienè, Audroné, Borin, Lars, Branco, António, Budin, Gerhard, Calzolari, Nicoletta, Daelemans, Walter, Garabík, Radovan, Grobelnik, Marko, García-Mateo, Carmen, van Genabith, Josef, Hajič, Jan, Hernáez, Inma, Judge, John, Koeva, Svetla, Krek, Simon, Krstev, Cvetana, Lindén, Krister, Magnini, Bernardo, Mariani, Joseph, McNaught, John, Melero, Maite, Monachini, Monica, Moreno, Asunción, Odijk, Jan, Ogrodniczuk, Maciej, Pęzik, Piotr, Piperidis, Stelios, Przepiórkowski, Adam, Rögnvaldsson, Eiríkur, Rosner, Mike, Pedersen, Bolette Sandford, Skadiņa, Inguna, De Smedt, Koenraad, Tadić, Marko, Thompson, Paul, Tufiş, Dan, Váradi, Tamás, Vasiļjevs, Andrejs, Vider, Kadri, Zabarskaitè, Jolanta

“…This article provides an overview of the dissemination work carried out in META-NET from 2010 until 2015; we describe its impact on the regional, national and…”
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The power of Prompts: Evaluating and Mitigating Gender Bias in MT with LLMs by Sant, Aleix, Escolano, Carlos, Mash, Audrey, Fornaciari, Francesca De Luca, Melero, Maite

“…This paper studies gender bias in machine translation through the lens of Large Language Models (LLMs). Four widely-used test sets are employed to benchmark…”
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A Hard Nut to Crack: Idiom Detection with Conversational Large Language Models by Fornaciari, Francesca De Luca, Altuna, Begoña, Gonzalez-Dios, Itziar, Melero, Maite

“…In this work, we explore idiomatic language processing with Large Language Models (LLMs). We introduce the Idiomatic language Test Suite IdioTS, a new dataset…”
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Converses al voltant de la intel·ligència artificial en clau catalana by Costa-Jussà, Marta R, Melero Nogués, Maite

“…Artificial intelligence moves millions of euros and occupies an important part of governments' political and strategic agendas. In this article we reflect on…”
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Investigating the translation capabilities of Large Language Models trained on parallel data only by Gilabert, Javier García, Escolano, Carlos, Savall, Aleix Sant, Fornaciari, Francesca De Luca, Mash, Audrey, Liao, Xixian, Melero, Maite

“…In recent years, Large Language Models (LLMs) have demonstrated exceptional proficiency across a broad spectrum of Natural Language Processing (NLP) tasks,…”
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On the Multilingual Capabilities of Very Large-Scale English Language Models by Armengol-Estapé, Jordi, Bonet, Ona de Gibert, Melero, Maite

“…Generative Pre-trained Transformers (GPTs) have recently been scaled to unprecedented sizes in the history of machine learning. These models, solely trained on…”
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