Search Results - "Melero, José A."

Progress in understanding and controlling respiratory syncytial virus: Still crazy after all these years by Collins, Peter L., Melero, José A.

“…Human respiratory syncytial virus (RSV) is a ubiquitous pathogen that infects everyone worldwide early in life and is a leading cause of severe lower…”
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Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development by Melero, José A, Mas, Vicente, McLellan, Jason S

“…Highlights • Human RSV glycoproteins are main targets of neutralizing and protective antibodies. • Important knowledge has been gained about G protein…”
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Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention by Magro, Margarita, Mas, Vicente, Chappell, Keith, Vázquez, Mónica, Cano, Olga, Luque, Daniel, Terrón, María C, Melero, José A, Palomo, Concepción

“…Human respiratory syncytial virus (hRSV) is the most important viral agent of pediatric respiratory infections worldwide. The only specific treatment available…”
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Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection by Detalle, Laurent, Stohr, Thomas, Palomo, Concepción, Piedra, Pedro A, Gilbert, Brian E, Mas, Vicente, Millar, Andrena, Power, Ultan F, Stortelers, Catelijne, Allosery, Koen, Melero, José A, Depla, Erik

“…Respiratory syncytial virus (RSV) is an important causative agent of lower respiratory tract infections in infants and elderly individuals. Its fusion (F)…”
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Ten Years of Global Evolution of the Human Respiratory Syncytial Virus BA Genotype with a 60-Nucleotide Duplication in the G Protein Gene by Trento, Alfonsina, Casas, Inmaculada, Calderón, Ana, Garcia-Garcia, Maria L., Calvo, Cristina, Perez-Breña, Pilar, Melero, José A.

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Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein by Battles, Michael B., Más, Vicente, Olmedillas, Eduardo, Cano, Olga, Vázquez, Mónica, Rodríguez, Laura, Melero, José A., McLellan, Jason S.

“…Human metapneumovirus (hMPV) is a frequent cause of bronchiolitis in young children. Its F glycoprotein mediates virus–cell membrane fusion and is the primary…”
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Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease by Polack, Fernando P, Delgado, Maria Florencia, Coviello, Silvina, Monsalvo, A Clara, Melendi, Guillermina A, Hernandez, Johanna Zea, Batalle, Juan P, Diaz, Leandro, Trento, Alfonsina, Chang, Herng-Yu, Mitzner, Wayne, Ravetch, Jeffrey, Melero, José A, Irusta, Pablo M

“…A formalin-inactivated vaccine from the 1960s against respiratory syncytial virus (RSV) failed to protect children. Although scientists thought that its…”
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The Pneumovirinae fusion (F) protein: A common target for vaccines and antivirals by Melero, José A., Mas, Vicente

“…•The Pneumoviriniae fusion (F) protein is the main target of neutralizing and protective antibodies.•Several conformations of the F protein have been…”
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Conservation of G-Protein Epitopes in Respiratory Syncytial Virus (Group A) Despite Broad Genetic Diversity: Is Antibody Selection Involved in Virus Evolution? by Trento, Alfonsina, Ábrego, Leyda, Rodriguez-Fernandez, Rosa, González-Sánchez, Maria Isabel, González-Martínez, Felipe, Delfraro, Adriana, Pascale, Juan M, Arbiza, Juan, Melero, José A

“…Worldwide G-glycoprotein phylogeny of human respiratory syncytial virus (hRSV) group A sequences revealed diversification in major clades and genotypes over…”
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Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation by Más, Vicente, Rodriguez, Laura, Olmedillas, Eduardo, Cano, Olga, Palomo, Concepción, Terrón, María C, Luque, Daniel, Melero, José A, McLellan, Jason S

“…Human metapneumovirus (hMPV) is a paramyxovirus that is a common cause of bronchiolitis and pneumonia in children less than five years of age. The hMPV fusion…”
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ISG15 Is Upregulated in Respiratory Syncytial Virus Infection and Reduces Virus Growth through Protein ISGylation by González-Sanz, Rubén, Mata, Manuel, Bermejo-Martín, Jesús, Álvarez, Amparo, Cortijo, Julio, Melero, José A, Martínez, Isidoro

“…Human respiratory syncytial virus (RSV), for which neither a vaccine nor an effective therapeutic treatment is currently available, is the leading cause of…”
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Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state by Rossey, Iebe, Gilman, Morgan S. A., Kabeche, Stephanie C., Sedeyn, Koen, Wrapp, Daniel, Kanekiyo, Masaru, Chen, Man, Mas, Vicente, Spitaels, Jan, Melero, José A., Graham, Barney S., Schepens, Bert, McLellan, Jason S., Saelens, Xavier

“…Human respiratory syncytial virus (RSV) is the main cause of lower respiratory tract infections in young children. The RSV fusion protein (F) is highly…”
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Trivalency of a Nanobody Specific for the Human Respiratory Syncytial Virus Fusion Glycoprotein Drastically Enhances Virus Neutralization and Impacts Escape Mutant Selection by Palomo, Concepción, Mas, Vicente, Detalle, Laurent, Depla, Erik, Cano, Olga, Vázquez, Mónica, Stortelers, Catelijne, Melero, José A

“…ALX-0171 is a trivalent Nanobody derived from monovalent Nb017 that binds to antigenic site II of the human respiratory syncytial virus (hRSV) fusion (F)…”
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Social, economic, and health impact of the respiratory syncytial virus: a systematic search by Díez-Domingo, Javier, Pérez-Yarza, Eduardo G, Melero, José A, Sánchez-Luna, Manuel, Aguilar, María Dolores, Blasco, Antonio Javier, Alfaro, Noelia, Lázaro, Pablo

“…Bronchiolitis caused by the respiratory syncytial virus (RSV) and its related complications are common in infants born prematurely, with severe congenital…”
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Neutralization of Human Respiratory Syncytial Virus Infectivity by Antibodies and Low-Molecular-Weight Compounds Targeted against the Fusion Glycoprotein by Magro, Margarita, Andreu, David, Gómez-Puertas, Paulino, Melero, José A, Palomo, Concepción

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Influence of Respiratory Syncytial Virus F Glycoprotein Conformation on Induction of Protective Immune Responses by Palomo, Concepción, Mas, Vicente, Thom, Michelle, Vázquez, Mónica, Cano, Olga, Terrón, María C, Luque, Daniel, Taylor, Geraldine, Melero, José A

“…Human respiratory syncytial virus (hRSV) vaccine development has received new impetus from structure-based studies of its main protective antigen, the fusion…”
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Influence of antigen conformation and mode of presentation on the antibody and protective responses against human respiratory syncytial virus: relevance for vaccine development by Melero, José A

“…Human respiratory syncytial virus (hRSV) remains one of the most prevalent human pathogens for which a vaccine is still missing. After several decades of…”
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Natural History of Human Respiratory Syncytial Virus Inferred from Phylogenetic Analysis of the Attachment (G) Glycoprotein with a 60-Nucleotide Duplication by TRENTO, Alfonsina, VIEGAS, Mariana, GALIANO, Monica, VIDELA, Cristina, CARBALLAL, Guadalupe, MISTCHENKO, Alicia S, MELERO, José A

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Recombinant Sendai Viruses Expressing Fusion Proteins with Two Furin Cleavage Sites Mimic the Syncytial and Receptor-Independent Infection Properties of Respiratory Syncytial Virus by RAWLING, Joanna, CANO, Olga, GARCIN, Dominique, KOLAKOFSKY, Daniel, MELERO, José A

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Low-pH-Induced Membrane Fusion Mediated by Human Metapneumovirus F Protein Is a Rare, Strain-Dependent Phenomenon by HERFST, Sander, MAS, Vicente, VER, Lorena S, WIERDA, Rutger J, OSTERHAUS, Albert D. M. E, FOUCHIER, Ron A. M, MELERO, José A

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