Search Results - "Melendez, Brenda"

IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma by Singh, Shubhra, Xiao, Zhilan, Bavisi, Karishma, Roszik, Jason, Melendez, Brenda D, Wang, Zhiqiang, Cantwell, Mark J, Davis, Richard E, Lizee, Greg, Hwu, Patrick, Neelapu, Sattva S, Overwijk, Willem W, Singh, Manisha

“…Inflammation has long been associated with cancer initiation and progression; however, how inflammation causes immune suppression in the tumor microenvironment…”
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Macrophage depletion through colony stimulating factor 1 receptor pathway blockade overcomes adaptive resistance to anti-VEGF therapy by Lyons, Yasmin A, Pradeep, Sunila, Wu, Sherry Y, Haemmerle, Monika, Hansen, Jean M, Wagner, Michael J, Villar-Prados, Alejandro, Nagaraja, Archana S, Dood, Robert L, Previs, Rebecca A, Hu, Wei, Zhao, Yang, Mak, Duncan H, Xiao, Zhilan, Melendez, Brenda D, Lizee, Gregory A, Mercado-Uribe, Imelda, Baggerly, Keith A, Hwu, Patrick, Liu, Jinsong, Overwijk, Willem W, Coleman, Robert L, Sood, Anil K

“…Anti-angiogenesis therapy has shown clinical benefit in patients with high-grade serous ovarian cancer (HGSC), but adaptive resistance rapidly emerges. Thus,…”
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Endometrial biomarkers in premenopausal women with obesity: an at-risk cohort by Dottino, Joseph A., Zhang, Qian, Loose, David S., Fellman, Bryan, Melendez, Brenda D., Borthwick, Mikayla S., McKenzie, Laurie J., Yuan, Ying, Yang, Richard K., Broaddus, Russell R., Lu, Karen H., Soliman, Pamela T., Yates, Melinda S.

“…Obesity is a well-known risk factor for endometrial cancer, but the mechanisms of obesity-related carcinogenesis are not well defined, particularly for…”
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Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity by Hailemichael, Yared, Johnson, Daniel H., Abdel-Wahab, Noha, Foo, Wai Chin, Bentebibel, Salah-Eddine, Daher, May, Haymaker, Cara, Wani, Khalida, Saberian, Chantal, Ogata, Dai, Kim, Sang T., Nurieva, Roza, Lazar, Alexander J., Abu-Sbeih, Hamzah, Fa'ak, Faisal, Mathew, Antony, Wang, Yinghong, Falohun, Adewunmi, Trinh, Van, Zobniw, Chrystia, Spillson, Christine, Burks, Jared K., Awiwi, Muhammad, Elsayes, Khaled, Soto, Luisa Solis, Melendez, Brenda D., Davies, Michael A., Wargo, Jennifer, Curry, Jonathan, Yee, Cassian, Lizee, Gregory, Singh, Shalini, Sharma, Padmanee, Allison, James P., Hwu, Patrick, Ekmekcioglu, Suhendan, Diab, Adi

“…Immune checkpoint blockade (ICB) therapy frequently induces immune-related adverse events. To elucidate the underlying immunobiology, we performed a deep…”
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Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers by Bradley, Sherille D., Talukder, Amjad H., Lai, Ivy, Davis, Rebecca, Alvarez, Hector, Tiriac, Herve, Zhang, Minying, Chiu, Yulun, Melendez, Brenda, Jackson, Kyle R., Katailiha, Arjun, Sonnemann, Heather M., Li, Fenge, Kang, Yaan, Qiao, Na, Pan, Bih-Fang, Lorenzi, Philip L., Hurd, Mark, Mittendorf, Elizabeth A., Peterson, Christine B., Javle, Milind, Bristow, Christopher, Kim, Michael, Tuveson, David A., Hawke, David, Kopetz, Scott, Wolff, Robert A., Hwu, Patrick, Maitra, Anirban, Roszik, Jason, Yee, Cassian, Lizée, Gregory

“…Cytotoxic T lymphocyte (CTL)-based cancer immunotherapies have shown great promise for inducing clinical regressions by targeting tumor-associated antigens…”
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Charge-based interactions through peptide position 4 drive diversity of antigen presentation by human leukocyte antigen class I molecules by Jackson, Kyle R, Antunes, Dinler A, Talukder, Amjad H, Maleki, Ariana R, Amagai, Kano, Salmon, Avery, Katailiha, Arjun S, Chiu, Yulun, Fasoulis, Romanos, Rigo, Maurício Menegatti, Abella, Jayvee R, Melendez, Brenda D, Li, Fenge, Sun, Yimo, Sonnemann, Heather M, Belousov, Vladislav, Frenkel, Felix, Justesen, Sune, Makaju, Aman, Liu, Yang, Horn, David, Lopez-Ferrer, Daniel, Huhmer, Andreas F, Hwu, Patrick, Roszik, Jason, Hawke, David, Kavraki, Lydia E, Lizée, Gregory

“…Human leukocyte antigen class I (HLA-I) molecules bind and present peptides at the cell surface to facilitate the induction of appropriate CD8+ T cell-mediated…”
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Not-so-mighty mitochondria: Mitochondrial dysfunction in mismatch repair deficient endometrial cancer development (234) by Waters, Mikayla, Melendez, Brenda, Chan, Wai Kin, Zhang, Qian, Lu, Karen, Yates, Melinda

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Spatial transcriptomics identifies unique loss of immunosurveillance in endometrial cancers of women with severe obesity by Fernandez, Estefania, Melendez, Brenda, Yang, Richard, Segura, Rossana Lazcano, Bowen, Mikayla, Wani, Khalida, Singh, Bhavana, Celestino, Joseph, Bernard, Laurence, Nguyen, Tri, Lazar, Alexander, Wargo, Jennifer, Lu, Karen, Yates, Melinda

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Correction: IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma by Singh, Shubhra, Xiao, Zhilan, Bavisi, Karishma, Roszik, Jason, Melendez, Brenda D, Wang, Zhiqiang, Cantwell, Mark J, Davis, Richard E, Lizee, Greg, Hwu, Patrick, Neelapu, Sattva S, Overwijk, Willem W, Singh, Manisha

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Abstract PR008: Identifying mechanisms of immune evasion in microsatellite instable endometrial cancer mouse models by Melendez, Brenda, Hinchcliff, Emily, Gokul, Nisha, Su, Xiaoping, McGrail, Daniel, Whitley, Elizabeth, Broaddus, Russell, Schmandt, Rosemarie, Lu, Karen, Yates, Melinda

“…Abstract Introduction: Microsatellite instability (MSI), caused by defects in DNA mismatch repair genes, including MLH1 and MSH2, occur in 30% of endometrial…”
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Abstract P015: Mechanisms of mitochondrial dysfunction in development of mismatch repair-deficient endometrial cancer by Moreno, Diana L., Borthwick, Mikayla S., Peralta, Leah, Chan, Wai Kin, Melendez, Brenda, Zhang, Qian, Gokul, Nisha, Yates, Melinda S.

“…Abstract Background: Lynch syndrome (LS) is a hereditary cancer syndrome carrying roughly 60% lifetime risk of endometrial cancer (EC) development. LS-EC is…”
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Abstract 3421: Identifying mechanisms of immune evasion in microsatellite instable endometrial cancers by Melendez, Brenda, Hinchcliff, Emily, Gokul, Nisha, Whitley, Elizabeth, Broaddus, Russell R., Schmandt, Rosemarie E., Lu, Karen H., Yates, Melinda S.

“…Abstract Inherited or sporadic defects in mismatch repair genes (MLH1, MSH2, MSH6, and PSM2) can lead to microsatellite instable (MSI) tumors, most commonly…”
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El papel de los profesionales de enfermería en el desarrollo y atención de la salud adolescente en Honduras by De Bortoli Cassiani, Silvia Helena, Moreno Dias, Bruna, Meléndez Romero, Brenda Elizabeth, Rivera, Jairo

“…Objetivo. Identificar y analizar el papel de los profesionales de enfermería en el desarrollo y la atención de la salud adolescente en Honduras, por medio del…”
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Correlation of cancer testis antigen expression with high type-I interferon signal and prognosis in small bowel neuroendocrine tumors by Ayabe, Reed I., Seo, Yongwoo David, Melendez, Brenda, Lazcano Segura, Rossana, Fields, Brittany C., Wani, Khalida M., Johnson, Sarah, Witt, Russell, Chelvanambi, Manoj, Hudgens, Courtney, Hernandez, Sharia D., Ajami, Nadim J., Wargo, Jennifer Ann, Lazar, Alexander J., Halperin, Daniel M., Estrella, Jeannelyn, Maxwell, Jess

“…596 Background: Patients with small bowel neuroendocrine tumors (SBNET) frequently present with metastatic disease, and efficacy of available therapies,…”
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Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8 + T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma by Peng, Weiyi, Williams, Leila J, Xu, Chunyu, Melendez, Brenda, McKenzie, Jodi A, Chen, Yuan, Jackson, Heather L, Voo, Kui S, Mbofung, Rina M, Leahey, Sara Elizabeth, Wang, Jian, Lizee, Gregory, Tawbi, Hussein A, Davies, Michael A, Hoos, Axel, Smothers, James, Srinivasan, Roopa, Paul, Elaine M, Yanamandra, Niranjan, Hwu, Patrick

“…OX40 agonist-based combinations are emerging as a novel avenue to improve the effectiveness of cancer immunotherapy. To better guide its clinical development,…”
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Long-term follow-up of levonorgestrel intrauterine device for atypical hyperplasia and early endometrial cancer reveals relapse characterized by immune exhaustion by Bowen, Mikayla Borthwick, Melendez, Brenda, Zhang, Qian, Yang, Richard K, Fellman, Bryan M, Lawson, Barrett C, Adjei, Naomi N, Celestino, Joseph, Wani, Khalida M, Singh, Bhavana, Urbauer, Diana L, Lazar, Alexander J, Lu, Karen H, Wargo, Jennifer A, Westin, Shannon N, Yates, Melinda S

“…Nonsurgical treatment options are increasingly needed for endometrial atypical hyperplasia (AH) and endometrioid endometrial cancer (EEC). Despite promising…”
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Abstract B025: IL6 signaling in pre-malignant obese endometrium and endometrial cancer by Zhang, Qian, Melendez, Brenda, Su, Xiaoping, Bowen, Mikayla, Celestino, Joseph, Yates, Melinda Sue, Lu, Karen

“…Abstract Objective: Obesity associated chronic inflammatory status plays a role in the increased endometrial cancer incidences, IL-6 is one of those…”
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Novel polymer-based system for intrauterine delivery of everolimus for anti-cancer applications by Melendez, Brenda, Shah, Sarita, Jiang, Yunyun, Dottino, Joseph, Watson, Emma, Pearce, Hannah, Borthwick, Mikayla, Schmandt, Rosemarie E., Zhang, Qian, Cumpian, Kayleah, Celestino, Joseph, Fellman, Bryan, Yuan, Ying, Lu, Karen H., Mikos, Antonios G., Yates, Melinda S.

“…Non-surgical treatment options for low-grade endometrial cancer and precancerous lesions are a critical unmet need for women who wish to preserve fertility or…”
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Endometrial biomarkers in premenopausal obese women: an at-risk cohort by DOTTINO, Joseph A., ZHANG, Qian, LOOSE, David S., FELLMAN, Bryan, MELENDEZ, Brenda D., WATERS, Mikayla S., MCKENZIE, Laurie J., YUAN, Ying, YANG, Richard K., BROADDUS, Russell R., LU, Karen H., SOLIMAN, Pamela T., YATES, Melinda S.

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BSBM-06 SINGLE-CELL SPATIAL ANALYSIS OF METASTATIC BRAIN TUMORS REVEALS INTRACELLULAR BACTERIAL SIGNAL AND THEIR CORRELATION WITH THE TUMOR MICROENVIRONMENT by Morad, Golnaz, Damani, Ashish, Melendez, Brenda, Singh, Bharat, Wong, Matthew, Sahasrabhojane, Pranoti, Hoballah, Yasmine, Veguilla, Fabiana, Losh, Jillian, Ajami, Nadim, Ferguson, Sherise, Wargo, Jennifer

“…Abstract Metastatic brain tumors are associated with significant morbidity and mortality. Recent trials have demonstrated the potential efficacy of…”
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