Search Results - "Melega, William P."

Methamphetamine blood concentrations in human abusers: Application to pharmacokinetic modeling by Melega, William P., Cho, Arthur K., Harvey, Dennis, Laćan, Goran

“…Characterization of methamphetamine's (METH) dose‐dependent effects on brain neurochemistry may represent a critical component for better understanding the…”
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Hypothalamic deep brain stimulation reduces weight gain in an obesity-animal model by Melega, William P, Lacan, Goran, Gorgulho, Alessandra A, Behnke, Eric J, De Salles, Antonio A F

“…Prior studies of appetite regulatory networks, primarily in rodents, have established that targeted electrical stimulation of ventromedial hypothalamus (VMH)…”
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BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease by Yong, Jing, Lacan, Goran, Dang, Hoa, Hsieh, Terry, Middleton, Blake, Wasserfall, Clive, Tian, Jide, Melega, William P, Kaufman, Daniel L

“…There is a growing interest in using vaccination with CNS antigens to induce autoreactive T cell responses that home to damaged areas in the CNS and ameliorate…”
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Long-Term Methamphetamine Administration in the Vervet Monkey Models Aspects of a Human Exposure: Brain Neurotoxicity and Behavioral Profiles by MELEGA, William P, JORGENSEN, Matthew J, LACAN, Goran, WAY, Baldwin M, PHAM, Jamie, MORTON, Grenvill, CHO, Arthur K, FAIRBANKS, Lynn A

“…Methamphetamine (METH)-associated alterations in the human striatal dopamine (DA) system have been identified with positron emission tomography (PET) imaging…”
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Identifying Heritable Brain Phenotypes in an Extended Pedigree of Vervet Monkeys by Fears, Scott C, Melega, William P, Service, Susan K, Lee, Chris, Chen, Kelly, Tu, Zhuowen, Jorgensen, Matthew J, Fairbanks, Lynn A, Cantor, Rita M, Freimer, Nelson B, Woods, Roger P

“…The area and volume of brain structural features, as assessed by high-resolution three-dimensional magnetic resonance imaging (MRI), are among the most…”
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Chemical and Biological Characterization of Particulate Matter (PM 2.5) and Volatile Organic Compounds Collected at Different Sites in the Los Angeles Basin by Cho, Arthur K, Shinkai, Yasuhiro, Schmitz, Debra A, Di Stefano, Emma, Eiguren-Fernandez, Arantza, Guarieiro, Aline Lefol Nani, Salinas, Erika M, Froines, John R, Melega, William P

“…Background: Most studies on air pollution (AP) exposure have focused on adverse health effects of particulate matter (PM). Less well-studied are the actions of…”
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Human Methamphetamine Pharmacokinetics Simulated in the Rat: Behavioral and Neurochemical Effects of a 72-h Binge by KUCZENSKI, Ronald, SEGAL, David S, MELEGA, William P, LACAN, Goran, MCCUNNEY, Stanley J

“…Bingeing is one pattern of high-dose methamphetamine (METH) abuse, which involves continuous drug taking over several days and can result in psychotic…”
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Prolonged exposure of rats to intravenous methamphetamine : behavioral and neurochemical characterization by SEGAL, David S, KUCZENSKI, Ronald, O'NEIL, Meghan L, MELEGA, William P, CHO, Arthur K

“…The translational value of preclinical models of methamphetamine abuse depends in large part on the degree to which the drug regimens used in animals produce…”
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Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss by Harvey, Dennis C, Lacan, Goran, Tanious, Simon P, Melega, William P

“…After administration of methamphetamine (METH) (2×2 mg/kg, 6 h apart) to vervet monkeys, long term but reversible dopaminergic deficits were observed in both…”
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A review of low-intensity focused ultrasound pulsation by Bystritsky, Alexander, Korb, Alex S, Douglas, Pamela K, Cohen, Mark S, Melega, William P, Mulgaonkar, Amit P, DeSalles, Antonio, Min, Byoung-Kyong, Yoo, Seung-Schik

“…With the recent approval by the Food and Drug Administration (FDA) of Deep Brain Stimulation (DBS) for Parkinson’s Disease, dystonia and obsessive compulsive…”
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Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by Laćan, Goran, Dang, Hoa, Middleton, Blake, Horwitz, Marcus A., Tian, Jide, Melega, William P., Kaufman, Daniel L.

“…We previously showed that, in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD), vaccination with bacillus…”
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Alterations in the striatal dopamine system during intravenous methamphetamine exposure: Effects of contingent and noncontingent administration by Laćan, Goran, Hadamitzky, Martin, Kuczenski, Ronald, Melega, William P.

“…ABSTRACT The continuing spread of methamphetamine (METH) abuse has stimulated research aimed at understanding consequences of its prolonged exposure…”
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Recovery of striatal dopamine function after acute amphetamine- and methamphetamine-induced neurotoxicity in the vervet monkey by Melega, William P, Raleigh, Michael J, Stout, David B, Lacan, Goran, Huang, Sung-Cheng, Phelps, Michael E

“…In six vervet monkeys, presynaptic striatal dopamine function was assessed longitudinally by [ 18F]fluoro- l-DOPA (FDOPA)–positron emission tomography (PET)…”
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Region-Specific Protein Abundance Changes in the Brain of MPTP-Induced Parkinson’s Disease Mouse Model by Zhang, Xu, Zhou, Jian-Ying, Chin, Mark H, Schepmoes, Athena A, Petyuk, Vladislav A, Weitz, Karl K, Petritis, Brianne O, Monroe, Matthew E, Camp, David G, Wood, Stephen A, Melega, William P, Bigelow, Diana J, Smith, Desmond J, Qian, Wei-Jun, Smith, Richard D

“…Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration in the nigrostriatal region of the brain; however, the neurodegeneration extends…”
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Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis Revealed by Proteomic and Transcriptomic Analyses of the Striata in Two Mouse Models of Parkinson’s Disease by Chin, Mark H, Qian, Wei-Jun, Wang, Haixing, Petyuk, Vladislav A, Bloom, Joshua S, Sforza, Daniel M, Laćan, Goran, Liu, Dahai, Khan, Arshad H, Cantor, Rita M, Bigelow, Diana J, Melega, William P, Camp, David G, Smith, Richard D, Smith, Desmond J

“…The molecular mechanisms underlying the changes in the nigrostriatal pathway in Parkinson’s disease (PD) are not completely understood. Here, we use mass…”
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Evaluation of a stereotactic frame for repositioning of the rat brain in serial positron emission tomography imaging studies by Rubins, Daniel J, Meadors, A.Ken, Yee, Simon, Melega, William P, Cherry, Simon R

“…For serial imaging studies of the rat brain with positron emission tomography (PET), reproducible positioning of the head can facilitate spatial alignment of…”
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Modulation of food intake following deep brain stimulation of the ventromedial hypothalamus in the vervet monkey : Laboratory investigation by LACAN, Goran, DE SALLES, Antonio A. F, GORGULHO, Alessandra A, KRAHL, Scott E, FRIGHETTO, Leonardo, BEHNKE, Eric J, MELEGA, William P

“…Deep brain stimulation (DBS) has become an effective therapy for an increasing number of brain disorders. Recently demonstrated DBS of the posterior…”
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Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain by Rubins, Daniel J, Melega, William P, Lacan, Goran, Way, Baldwin, Plenevaux, Alain, Luxen, Andre, Cherry, Simon R

“…An automated method for placement of 3D rat brain atlas-derived volumes of interest (VOIs) onto PET studies has been designed and evaluated. VOIs representing…”
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Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge by O'Neil, Meghan L., Kuczenski, Ronald, Segal, David S., Cho, Arthur K., Lacan, Goran, Melega, William P.

“…A major feature of human methamphetamine (METH) abuse is the gradual dose escalation that precedes high‐dose exposure. The period of escalating doses (EDs) is…”
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Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge by SEGAL, David S, KUCZENSKI, Ronald, O'NEIL, Meghan L, MELEGA, William P, CHO, Arthur K

“…The neurotoxic effects of methamphetamine (METH) have been characterized primarily from the study of high-dose binge regimens in rodents. However, this drug…”
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