Search Results - "Melecchi, Alberto"
-
1
Natural History of Glaucoma Progression in the DBA/2J Model: Early Contribution of Müller Cell Gliosis
Published in Cells (Basel, Switzerland) (27-04-2023)“…Glaucoma is a chronic optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) and the…”
Get full text
Journal Article -
2
Preventive Efficacy of an Antioxidant Compound on Blood Retinal Barrier Breakdown and Visual Dysfunction in Streptozotocin-Induced Diabetic Rats
Published in Frontiers in pharmacology (03-01-2022)“…In diabetic retinopathy (DR), high blood glucose drives chronic oxidative stress and inflammation that trigger alterations of the neurovascular balance finally…”
Get full text
Journal Article -
3
Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma
Published in Frontiers in medicine (05-09-2023)“…Introduction Much interest has been addressed to antioxidant dietary supplements that are known to lower the risk of developing glaucoma or delay its…”
Get full text
Journal Article -
4
Increased efficacy of dietary supplement containing wax ester-rich marine oil and xanthophylls in a mouse model of dry macular degeneration
Published in Frontiers in pharmacology (13-10-2022)“…Age-related macular degeneration (AMD) is nowadays considered among the retinal diseases whose clinical management lacks established treatment approaches,…”
Get full text
Journal Article -
5
Liposome-Mediated Delivery Improves the Efficacy of Lisosan G against Retinopathy in Diabetic Mice
Published in Cells (Basel, Switzerland) (01-10-2023)“…Nutraceuticals are natural substances whose anti-oxidant and anti-inflammatory properties may be used to treat retinal pathologies. Their efficacy is limited…”
Get full text
Journal Article -
6
Meldonium Inhibits Cell Motility and Wound-Healing in Trabecular Meshwork Cells and Scleral Fibroblasts: Possible Applications in Glaucoma
Published in Pharmaceuticals (Basel, Switzerland) (01-04-2023)“…Meldonium (MID) is a synthetic drug designed to decrease the availability of L-carnitine-a main player in mitochondrial energy generation-thus modulating the…”
Get full text
Journal Article -
7
Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model
Published in Biomedicines (07-09-2021)“…Light-induced retinal damage (LD) is characterized by the accumulation of reactive oxygen species leading to oxidative stress and photoreceptor cell death. The…”
Get full text
Journal Article -
8
Agonism of β3-Adrenoceptors Inhibits Pathological Retinal Angiogenesis in the Model of Oxygen-Induced Retinopathy
Published in Investigative ophthalmology & visual science (01-08-2024)“…In response to hypoxia, sympathetic fibers to the retina activate β-adrenoceptors (β-ARs) that play an important role in the regulation of vascular and…”
Get full text
Journal Article -
9
Local modulation of thyroid hormone signaling in the retina affects the development of diabetic retinopathy
Published in Biochimica et biophysica acta. Molecular basis of disease (01-01-2024)“…Thyroid hormone (TH) dyshomeostasis is associated with poor prognosis in acute and prolonged illness, but its role in diabetic retinopathy (DR) has never been…”
Get full text
Journal Article -
10
Efficacy of a Spearmint (Mentha spicata L.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma
Published in Translational vision science & technology (01-11-2023)“…Glaucoma is an eye-brain axis disorder characterized by loss of retinal ganglion cells (RGCs). Although the role of intraocular pressure (IOP) elevation in…”
Get full text
Journal Article