Search Results - "Mele, Tina"

Early mobilization in the critical care unit: A review of adult and pediatric literature by Cameron, Saoirse, MA, Ball, Ian, MD, MSc, Cepinskas, Gediminas, DVM, PhD, Choong, Karen, MB, BCh, MSc, Doherty, Timothy J., MD, PhD, Ellis, Christopher G., PhD, Martin, Claudio M., MD, MSc, Mele, Tina S., MD, PhD, Sharpe, Michael, MD, Shoemaker, J. Kevin, PhD, Fraser, Douglas D., MD, PhD

“…Abstract Early mobilization of critically ill patients is beneficial, suggesting that it should be incorporated into daily clinical practice. Early passive,…”
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A robust scoring system to evaluate sepsis severity in an animal model by Shrum, Bradly, Anantha, Ram V, Xu, Stacey X, Donnelly, Marisa, Haeryfar, S M Mansour, McCormick, John K, Mele, Tina

“…The lack of a reliable scoring system that predicts the development of septic shock and death precludes comparison of disease and/or treatment outcomes in…”
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Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide by Abulizi, Palida, Loganathan, Neruja, Zhao, Duo, Mele, Tina, Zhang, Yixin, Zwiep, Terry, Liu, Kexiang, Zheng, Xiufen

“…Septic acute kidney injury (AKI) and myocardial dysfunction are leading causes of mortality with no accepted method of therapy. In this study we demonstrate…”
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Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis: the role of NLRP3 inflammasome activation by Zhang, Wenbo, Xu, Xuemei, Kao, Raymond, Mele, Tina, Kvietys, Peter, Martin, Claudio M, Rui, Tao

“…Myocardial contractile dysfunction in sepsis is associated with the increased morbidity and mortality. Although the underlying mechanisms of the cardiac…”
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GDF15 Regulates Malat-1 Circular RNA and Inactivates NFκB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation by Zhang, Yixin, Zhang, Guangfeng, Liu, Yanling, Chen, Renqi, Zhao, Duo, McAlister, Vivian, Mele, Tina, Liu, Kexiang, Zheng, Xiufen

“…Recombinant human growth differentiation factor 15 (rhGDF15) affects dendritic cell (DC) maturation. However, whether GDF15 is expressed in DCs and its roles…”
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Discordant rearrangement of primary and anamnestic CD8+ T cell responses to influenza A viral epitopes upon exposure to bacterial superantigens: Implications for prophylactic vaccination, heterosubtypic immunity and superinfections by Meilleur, Courtney E, Memarnejadian, Arash, Shivji, Adil N, Benoit, Jenna M, Tuffs, Stephen W, Mele, Tina S, Singh, Bhagirath, Dikeakos, Jimmy D, Topham, David J, Mu, Hong-Hua, Bennink, Jack R, McCormick, John K, Haeryfar, S M Mansour

“…Infection with (SAg)-producing bacteria may precede or follow infection with or vaccination against influenza A viruses (IAVs). However, how SAgs alter the…”
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Harnessing the Versatility of Invariant NKT Cells in a Stepwise Approach to Sepsis Immunotherapy by Choi, Joshua, Mele, Tina S, Porcelli, Steven A, Savage, Paul B, Haeryfar, S M Mansour

“…Sepsis results from a heavy-handed response to infection that may culminate in organ failure and death. Many patients who survive acute sepsis become…”
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Longitudinal analysis of mucosa‐associated invariant T cells in sepsis reveals their early numerical decline with prognostic implications and a progressive loss of antimicrobial functions by Choi, Joshua, Schmerk, Crystal L, Mele, Tina S, Rudak, Patrick T, Wardell, Christine M, Deng, Gansen, Pavri, Farzan R, Kim, Kyoungok, Cepinskas, Gediminas, He, Wenqing, Haeryfar, SM Mansour

“…Sepsis‐elicited immunosuppression elevates the risk of secondary infections. We used a clinically relevant mouse model and serial peripheral blood samples from…”
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Implementation of an Acute Care Surgery Service Facilitates Modern Clinical Practice Guidelines for Gallstone Pancreatitis by Murphy, Patrick B., MD, Paskar, Dave, MD, FRCSC, Parry, Neil G., MD, FRCSC, FACS, Racz, Jennifer, MD, FRCSC, Vogt, Kelly N., MD, FRCSC, Symonette, Caitlin, MD, Leslie, Ken, MD, FRCSC, Mele, Tina S., MD, FRCSC, FACS

“…Background Current practice guidelines for management of gallstone pancreatitis (GSP) recommend early cholecystectomy for patient stabilization and bile duct…”
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Knowledge translation tools to guide care of non-intubated patients with acute respiratory illness during the COVID-19 Pandemic by Leasa, David, Cameron, Paul, Honarmand, Kimia, Mele, Tina, Bosma, Karen J

“…Providing optimal care to patients with acute respiratory illness while preventing hospital transmission of COVID-19 is of paramount importance during the…”
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Bacterial Superantigens Expand and Activate, Rather than Delete or Incapacitate, Preexisting Antigen-Specific Memory CD8+ T Cells by Meilleur, Courtney E, Wardell, Christine M, Mele, Tina S, Dikeakos, Jimmy D, Bennink, Jack R, Mu, Hong-Hua, McCormick, John K, Haeryfar, S M Mansour

“…Abstract Superantigens (SAgs) released by common Gram-positive bacterial pathogens have been reported to delete, anergize, or activate mouse T cells. However,…”
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Gender Disparities in Medical Student Surgical Skills Education by Ryan, Joanna F., Istl, Alexandra C., Luhoway, Jacqueline A., Davidson, Jacob, Christakis, Nicole, Bütter, Andreana, Mele, Tina S.

“…Female medical students and surgical trainees are more likely to lack confidence in their clinical abilities than their male peers despite equal or superior…”
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Acute care surgery: a means for providing cost-effective, quality care for gallstone pancreatitis by Murphy, Patrick B, Paskar, Dave, Hilsden, Richard, Koichopolos, Jennifer, Mele, Tina S

“…Modern practice guidelines recommend index cholecystectomy (IC) for patients admitted with gallstone pancreatitis (GSP). However, this benchmark has been…”
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Timely Surgical Care for Acute Biliary Disease: An Indication of Quality by Murphy, Patrick B, Vogt, Kelly N, Mele, Tina S, Hameed, S Morad, Ball, Chad G, Parry, Neil G

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Timely Surgical Care for Acute Biliary Disease: An Indication of Quality by Murphy, Patrick B, Vogt, Kelly N, Mele, Tina S, Hameed, S Morad, Ball, Chad G, Parry, Neil G

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Different Surgeon, Different Duration: Lack of Consensus on the Appropriate Duration of Antimicrobial Prophylaxis and Therapy in Surgical Practice by Delaplain, Patrick T, Kaafarani, Haytham M A, Benedict, L Andrew O, Guidry, Christopher A, Kim, Dennis, Loor, Michele M, Machado-Aranda, David, Mele, Tina S, Mendoza, April E, Morris-Stiff, Gareth, Rattan, Rishi, Upperman, Jeffrey S, Barie, Philip S, Schubl, Sebastian D

“…The principles of antimicrobial stewardship promote the appropriate prescribing of agents with respect to efficacy, safety, duration, and cost. Antibiotic…”
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The role of miR-711 in cardiac cells in response to oxidative stress and its biogenesis: a study on H9C2 cells by Zhao, Duo, Zheng, Hao, Greasley, Adam, Ling, Fengjun, Zhou, Qinfeng, Wang, Bowen, Ni, Tiffany, Topiwala, Ishita, Zhu, Cuilin, Mele, Tina, Liu, Kexiang, Zheng, Xiufen

“…Oxidative stress results in cell apoptosis/death and plays a detrimental role in disease development and progression. Stressors alter the miRNA expression…”
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What counts as patient-important upper gastrointestinal bleeding in the ICU? A mixed-methods study protocol of patient and family perspectives by Cook, Deborah J, Swinton, Marilyn E, Krewulak, Karla D, Fiest, Kirsten, Dionne, Joanna C, Debigare, Sylvie, Guyatt, Gordon H, Taneja, Shipra, Alhazzani, Waleed, Burns, Karen E A, Marshall, John C, Muscedere, John G, Gouskos, Audrey, Finfer, Simon, Deane, Adam M, Myburgh, John A, Rochwerg, Bram, Ball, Ian, Mele, Tina, Niven, Daniel J, English, Shane W, Verhovsek, Madeleine, Vanstone, Meredith

“…IntroductionClinically important upper gastrointestinal bleeding is conventionally defined as bleeding accompanied by haemodynamic changes, requiring red blood…”
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Surgical Infections and the Future of Research: Re-Defining the Research Agenda for the Surgical Infection Society by Delaplain, Patrick T, Kaafarani, Haytham M A, Benedict, L Andrew O, Guidry, Christopher A, Kim, Dennis, Loor, Michele M, Machado-Aranda, David, Mele, Tina S, Mendoza, April E, Morris-Stiff, Gareth, Rattan, Rishi, Upperman, Jeffrey S, Barie, Philip S, Schubl, Sebastian D

“…Infections represent a major component of surgical practice. Risk mitigation, seeking eradication and optimal patient outcomes, require a concerted, multifocal…”
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Improving gender equity in critical care medicine: a protocol to establish priorities and strategies for implementation by Parsons Leigh, Jeanna, de Grood, Chloe, Ahmed, Sofia, Bosma, Karen, Burns, Karen E A, Fowler, Robert, Fox-Robichaud, Alison, Mehta, Sangeeta, Mele, Tina, Straus, Sharon E, Zepeda, Nubia, Kemp, Laryssa, Fiest, Kirsten, Stelfox, Henry Thomas

“…IntroductionWhile the number of women entering medical school now equals or surpasses the number of men, gender equity in medicine has not been achieved. Women…”
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