Search Results - "Meldrum, S."

Glutamate as a neurotransmitter in the brain: review of physiology and pathology by Meldrum, B S

“…Glutamate is the principal excitatory neurotransmitter in brain. Our knowledge of the glutamatergic synapse has advanced enormously in the last 10 years,…”
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Molecular Targets for Antiepileptic Drug Development by Meldrum, Brian S., Rogawski, Michael A.

“…This review considers how recent advances in the physiology of ion channels and other potential molecular targets, in conjunction with new information on the…”
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Postnatal Fish Oil Supplementation in High-Risk Infants to Prevent Allergy: Randomized Controlled Trial by D'VAZ, N, MELDRUM, S. J, DUNSTAN, J. A, MARTINO, D, MCCARTHY, S, METCALFE, J, TULIC, M. K, MORI, T. A, PRESCOTT, S. L

“…Relative deficiency of dietary omega 3 polyunsaturated fatty acids (n-3 PUFA) has been implicated in the rising allergy prevalence in Westernized countries…”
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Genetically epilepsy-prone rats (GEPRs) and DBA/2 mice: Two animal models of audiogenic reflex epilepsy for the evaluation of new generation AEDs by De Sarro, Giovambattista, Russo, Emilio, Citraro, Rita, Meldrum, Brian S

“…Abstract This review summarizes the current knowledge about DBA/2 mice and genetically epilepsy-prone rats (GEPRs) and discusses the contribution of such…”
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Fish oil supplementation in early infancy modulates developing infant immune responses by D'Vaz, N., Meldrum, S. J., Dunstan, J. A., Lee-Pullen, T. F., Metcalfe, J., Holt, B. J., Serralha, M., Tulic, M. K., Mori, T. A., Prescott, S. L.

“…Background Maternal fish oil supplementation during pregnancy has been associated with altered infant immune responses and a reduced risk of infant…”
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25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life by Jones, A.P., D'Vaz, N., Meldrum, S., Palmer, D.J., Zhang, G., Prescott, S.L.

“…Summary Background Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease in multiple observational studies. While…”
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The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood by Dunstan, J. A., West, C., McCarthy, S., Metcalfe, J., Meldrum, S., Oddy, W. H., Tulic, M. K., D'Vaz, N., Prescott, S. L.

“…To cite this article: Dunstan JA, West C, McCarthy S, Metcalfe J, Meldrum S, Oddy WH, Tulic MK, D’Vaz N, Prescott SL. The relationship between maternal folate…”
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Update on the mechanism of action of antiepileptic drugs by Meldrum, B S

“…Novel antiepileptic drugs (AEDs) are thought to act on voltage-sensitive ion channels, on inhibitory neurotransmission or on excitatory neurotransmission. Two…”
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The role of glutamate in epilepsy and other CNS disorders by MELDRUM, B. S

“…Glutamate is the principal excitatory neurotransmitter in the brain and, as such, it inevitably plays a role in the initiation and spread of seizure activity…”
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Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives by Meldrum, Brian S

“…Selective neuronal loss following status epilepticus was first described just under 100 years ago. The acute pathology following status epilepticus was shown…”
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Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893) by Chapman, Astrid G, Nanan, Karl, Williams, Martin, Meldrum, Brian S

“…The selective mGlu5 antagonists, MPEP, 2-methyl-6-phenylethynyl-pyridine, and SIB1893, (E)-6-methyl-2-styryl-pyridine, have been evaluated as antiepileptic…”
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Neonatal protein kinase C zeta expression determines the neonatal T-Cell cytokine phenotype and predicts the development and severity of infant allergic disease by D'Vaz, N., Ma, Y., Dunstan, J. A., Lee-Pullen, T. F., Hii, C., Meldrum, S., Zhang, G., Metcalfe, J., Ferrante, A., Prescott, S. L.

“…Background Previous studies have demonstrated that reduced T‐cell protein kinase C zeta (PKCζ) expression is associated with allergy development in infants…”
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The ‘glial’ glutamate transporter, EAAT2 (Glt‐1) accounts for high affinity glutamate uptake into adult rodent nerve endings by Suchak, Sachin K., Baloyianni, Nicoletta V., Perkinton, Michael S., Williams, Robert J., Meldrum, Brian S., Rattray, Marcus

“…The excitatory amino acid transporters (EAAT) removes neurotransmitters glutamate and aspartate from the synaptic cleft. Most CNS glutamate uptake is mediated…”
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Physical Activity and Psychological Health in Breast Cancer Survivors: An Application of Basic Psychological Needs Theory by Mack, Diane E., Meldrum, Lindsay S., Wilson, Philip M., Sabiston, Catherine M.

“…Objective: The role of psychological need satisfaction in terms of understanding the mechanisms through which leisure‐time physical activity (LTPA) is…”
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Implications for neuroprotective treatments by Meldrum, Brian S

“…Pharmacological neuroprotection against the consequences of seizures can be considered as primary neuroprotection where the object is to diminish the initial…”
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Determinants of DHA levels in early infancy: Differential effects of breast milk and direct fish oil supplementation by Meldrum, S.J, D'Vaz, N, Casadio, Y, Dunstan, J.A, Niels Krogsgaard-Larsen, N, Simmer, K, Prescott, S.L

“…Abstract Introduction Although omega ( n )-3 long-chain polyunsaturated fatty acids (LCPUFA), particularly docosahexaenoic acid (DHA), intakes are important…”
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Glutamate receptors and transporters in genetic and acquired models of epilepsy by Meldrum, B.S, Akbar, M.T, Chapman, A.G

“…Glutamate, the principal excitatory neurotransmitter in the brain, acts on three families of ionotropic receptor—AMPA…”
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Regional Expression of Multidrug Resistance Genes in Genetically Epilepsy‐prone Rat Brain after a Single Audiogenic Seizure by Kwan, Patrick, Sills, Graeme J., Butler, Elaine, Gant, Timothy W., Meldrum, Brian S., Brodie, Martin J.

“…Purpose: The multidrug resistance (mdr) gene family encodes the drug transport macromolecule P‐glycoprotein (P‐gp), which contributes to the functionality of…”
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The Infant Fish Oil Supplementation Study (IFOS): Design and research protocol of a double-blind, randomised controlled n−3 LCPUFA intervention trial in term infants by Meldrum, S.J, D'Vaz, N, Dunstan, J, Mori, T.A, Prescott, S.L

“…Abstract Study design The Infant Fish Oil Supplementation Study is a double-blind randomised controlled trial investigating whether the incidence of allergic…”
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Basic Mechanisms of Gabitril (Tiagabine) and Future Potential Developments by Meldrum, Brian S., Chapman, Astrid G.

“…Gabitril (tiagabine) is a potent selective inhibitor of the principal neuronal γ‐aminobutyric acid (GABA) transporter (GAT‐1) in the cortex and hippocampus. By…”
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