Search Results - "Melchior, George W"

Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein by Marotti, Keith R, Castle, Christine K, Boyle, Timothy P, Lin, Alice H, Murray, Robert W, Melchior, George W

“…Cholesteryl ester transfer protein (CETP) is a plasma protein that mediates the exchange of neutral lipids among the lipoprotein. Because the principal core…”
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Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide by Stratman, Nancy C., Castle, Christine K., Taylor, Bruce M., Epps, Dennis E., Melchior, George W., Carter, Donald B.

“…Brain plaque deposits of amyloid-beta peptide (Aβ) is a pathological hallmark of Alzheimer's disease (AD) and apolipoprotein E (apoE) is thought to be involved…”
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Centripetal cholesterol flux from extrahepatic organs to the liver is independent of the concentration of high density lipoprotein-cholesterol in plasma by Osono, Y. (University of Texas Southwestern Medical Center, Dallas, TX.), Woollett, L.A, Marotti, K.R, Melchior, G.W, Dietschy, J.M

“…High density lipoproteins (HDLs) play a role in two processes that include the amelioration of atheroma formation and the centripetal flow of cholesterol from…”
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Remodeling of the HDL in NIDDM: a fundamental role for cholesteryl ester transfer protein by Castle, C.K, Kuiper, S.L, Blake, W.L, Paigen, B, Marotti, K.R, Melchior, G.W

“…When the Ay gene is expressed in KK mice, the yellow offspring (KKAy mice) become obese, insulin resistant, hyperglycemic, and severely hypertriglyceridemic,…”
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Evidence That Cynomolgus Monkey Cholesteryl Ester Transfer Protein Has Two Neutral Lipid Binding Sites (∗) by Melchior, George W., Greenlee, Kelly A., Castle, Christine K., Prough, Michael J., Milne, Ross W., Marotti, Keith R., Kezdy, Ferenc J.

“…Two inhibitors of cynomolgus monkey cholesteryl ester transfer protein were evaluated. One, a monoclonal antibody made against purified cynomolgus monkey…”
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Pioglitazone hydrochloride inhibits cholesterol absorption and lowers plasma cholesterol concentrations in cholesterol-fed rats by COLCA, J. R, DAILEY, C. F, PALAZUK, B. J, HILLMAN, R. M, DINH, D. M, MELCHIOR, G. W, SPILMAN, C. H

“…Diabetes is associated with altered cholesterol metabolism that may contribute to cardiovascular complications. Treatment of rats with pioglitazone…”
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Inhibition of Receptor-Mediated Clearance of Lysine and Arginine-Modified Lipoproteins from the Plasma of Rats and Monkeys by Mahley, Robert W., Weisgraber, Karl H., Melchior, George W., Innerarity, Thomas L., Holcombe, Kathleen S.

“…Reductive methylation of at least 30% of the lysine residues or 1,2-cyclohexanedione modification of 45% of the arginine residues prevented low density…”
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Cryopreservation of Cynomolgus Monkey (Macaca fascicularis) Hepatocytes for Subsequent Culture and Protein Synthesis Studies by Elena L. Sun, Danielle G. Aspar, Ulrich, Roger G., Melchior, George W.

“…A method is described for the preservation and subsequent recovery of hepatocytes obtained by collagenase perfusion of cynomolgus monkey (Macaca fascicularis)…”
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Cholesteryl ester transfer protein's role in high-density lipoprotein metabolism by Melchior, George W., Marotti, Keith R.

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Lipoprotein profile characterization of the KKA(y) mouse, a rodent model of type II diabetes, before and after treatment with the insulin-sensitizing agent pioglitazone by Castle, C K, Colca, J R, Melchior, G W

“…The purpose of this study was to characterize the lipoprotein profile in the KKA(y) mouse, a rodent model of type II diabetes, before and after treatment with…”
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Apolipoprotein A-I metabolism in cholesteryl ester transfer protein transgenic mice: insights into the mechanisms responsible for low plasma high density lipoprotein levels by Melchior, G.W, Castle, C.K, Murray, R.W, Blake, W.L, Dinh, D.M, Marotti, K.R

“…Expression of simian cholesteryl ester transfer protein (CETP) in C57BL/6 mice causes the animals' high density lipoprotein (HDL) levels to decrease. The…”
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Cholesteryl ester transfer protein's role in high-density lipoprotein metabolism: Insights from studies with transgenic mice by Melchior, George W., Marotti, Keith R.

“…A substantial percentage of people who develop coronary artery atherosclerosis have plasma cholesterol levels in the “desirable” range. The principal lipid…”
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The development of fatty liver is accelerated in transgenic mice expressing cynomolgus monkey cholesteryl ester transfer protein by Blake, W L, Ulrich, R G, Marotti, K R, Melchior, G W

“…Expression of cynomolgus monkey cholesteryl ester transfer protein (CETP) in C57BL/6 mice has been shown to have a profound effect on the lipoprotein profile…”
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Effects of epidermal growth factor on apo B mRNA levels and apo B accumulation in the media of primate hepatocytes in culture by Blake, W L, Vidmar, T J, Melchior, G W

“…EGF has been shown to augment albumin and apolipoprotein A-I secretion by cynomolgus monkey hepatocytes in primary culture without stimulating cell division…”
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Co-expression of cholesteryl ester transfer protein and defective apolipoprotein E in transgenic mice alters plasma cholesterol distribution. Implications for the pathogenesis of type III hyperlipoproteinemia by S Fazio, K R Marotti, Y L Lee, C K Castle, G W Melchior, S C Rall, Jr

“…Despite the definite etiologic link between apolipoprotein (apo) E mutations and type III hyperlipoproteinemia (HLP), it is not clear what additional factors…”
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Evidence that the nonparenchymal cells of the liver are the principal source of cholesteryl ester transfer protein in primates by PAPE, M. E, ULRICH, R. G, REAL, T. J, MAROTTI, K. R, MELCHIOR, G. W

“…Previous studies showed that 90% or more of the cholesteryl ester transfer protein (CETP) mRNA is contained in the liver of cynomolgus monkeys. The purpose of…”
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Purification of human cholesteryl ester transfer protein by affinity chromatography on immobilized triazine dyes by Rehberg, E F, Greenlee, K A, Melchior, G W, Marotti, K R

“…Human cholesteryl ester transfer protein was purified from lipoprotein-depleted serum or plasma in a three-step procedure utilizing commercially available…”
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Apo E levels and distribution in rhesus monkeys consuming an atherogenic diet by Melchior, G W, Willard, S C, Brandon, M T

“…The effect of an atherogenic diet on serum apo E levels and distribution among the lipoproteins of rhesus monkeys was studied. Animals able to maintain their…”
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Apo A-I metabolism in cynomolgus monkeys: male-female differences by Melchior, G W, Castle, C K, Vidmar, T J, Polites, H G, Marotti, K R

“…Female cynomolgus monkeys have significantly higher plasma apo A-I concentrations than males (P = 0.04) and are able to maintain higher levels than the males…”
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The effect of polyunsaturated fats on bile acid metabolism and cholelithiasis in squirrel monkeys by Melchior, G W, Lofland, H B, St Clair, R W

“…Squirrel monkeys (Saimiri sciureus) were fed diets containing safflower oil, butter, or coconut oil and 1 mg cholesterol/cal for 15--17 mo to examine the…”
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