Search Results - "Melchior, Donald L."

A liposomal method for evaluation of inhibitors of H+−coupled multidrug transporters by Melchior, Donald L., Brill, Shlomo, Wright, George E., Schuldiner, Shimon

“…This paper describes a novel technique, Fluorosomes, applied to investigating the interaction of antimicrobials with proton driven microbial efflux…”
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Determining P-glycoprotein–drug interactions: Evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers by Melchior, Donald L., Sharom, Frances J., Evers, Raymond, Wright, George E., Chu, Joseph W.K., Wright, Stephen E., Chu, Xiaoyan, Yabut, Jocelyn

“…P-Glycoprotein (ABCB1, MDR1) is a multidrug efflux pump that is a member of the ATP-binding cassette (ABC) superfamily. Many drugs in common clinical use are…”
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A rapid empirical method for measuring membrane bilayer entry equilibration of molecules by Melchior, Donald L

“…The therapeutic potency of many drugs is limited by their interactions with cell membranes. The ability of a drug to cross lipid barriers, such as those of…”
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Lipid Domains in Fluid Membranes: A Quick-Freeze Differential Scanning Calorimetry Study by Melchior, Donald L.

“…The application of rapid-freezing techniques to differential scanning calorimetry (DSC) provides a new approach for understanding the organization of lipids in…”
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The Fluorosome™ technique for investigating membrane on- and off-loading of drugs by β-CD and sonicated SUV by Fix, Marina, Melchior, Donald L

“…The application of the Fluorosome technique to test drug delivery systems is described. Fluorosomes, egg phosphatidylcholine liposomes with bilayer embedded…”
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Dilatometry of dipalmitoyllecithin-cholesterol bilayers by Melchior, Donald L, Scavitto, Francis J, Steim, Joseph M

“…The interactions of cholesterol and dipalmitoyl-phosphatidylcholine in bilayers were investigated by differential scanning dilatometry and related techniques…”
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Dilatometry of dilute suspensions of synthetic lecithin aggregates by Melchior, Donald L, Morowitz, Harold J

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Preferential association of membrane phospholipids with the human erythrocyte hexose transporter by Naderi, Shokofeh, Doyle, Kay, Melchior, Donald L

“…This study reports the results of an investigation to determine to what extent the influence of membrane lipids on the human erythrocyte sugar transporter…”
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Effects of bilayer cholesterol on human erythrocyte hexose transport protein activity in synthetic lecithin bilayers by Connally, Timothy J, Carruthers, Anthony, Melchior, Donald L

“…In this study, we describe the effects of altered bilayer cholesterol content on reconstituted, protein-mediated sugar transport. The system used was the human…”
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Reconstituted human erythrocyte sugar transporter activity is determined by bilayer lipid groups by Tefft, Robert E, Carruthers, Anthony, Melchior, Donald L

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Calorimetric investigation of the phase partitioning of the fluorescent carbocyanine probes in phosphatidylcholine bilayers by Ethier, Michael F, Wolf, David E, Melchior, Donald L

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Dilatometry of biological membranes by Melchior, Donald L, Morowitz, Harold J

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Lipid domains in the ram sperm plasma membrane demonstrated by differential scanning calorimetry by Wolf, D.E. (Worcester Foundation for Experimental Biology, Shrewsbury, MA), Maynard, V.M, McKinnon, C.A, Melchior, D.L

“…Mammalian sperm plasma membranes, in contrast to those of mammalian somatic cells, exhibit a significant fraction of lipid that does not diffuse laterally in…”
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Quick-Freeze Lipid Techniques: Correction by Melchior, Donald L.

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A firefly luciferase assay for subnanomolar concentrations of amphipathic substances by Naderi, S, Melchior, D L

“…A sensitive assay is described for accurately quantitating subnanomolar aqueous concentrations of a wide variety of amphipathic and hydrophobic biological…”
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Modulation of red blood cell sugar transport by lyso-lipid by Naderi, S, Carruthers, A, Melchior, D L

“…The in vitro presentation to red blood cells of specific lysolipids in amounts comparable to lysolipid levels in serum is shown to markedly influence…”
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Alterations in red blood cell sugar transport by nanomolar concentrations of alkyl lysophospholipid by Melchior, D L, Carruthers, A, Makriyannis, A, Duclos, Jr, R I, Abdel-Mageed, O H

“…Acyl lysolipids presented in vitro to red blood cells in amounts comparable to blood serum levels inhibit protein-mediated glucose transport (Naderi, A.,…”
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Reconstituted human erythrocyte sugar transporter activity is determined by bilayer lipid head groups by TEFFT, R. E. JR, CARRUTHERS, A, MELCHIOR, D. L

“…The effects of bilayer lipid head group on human erythrocyte passive sugar transport protein activity were examined by reconstituting the transporter into…”
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The preparation and characterization of liposomes containing X-ray contrast agents by Ryan, P J, Davis, M A, Melchior, D L

“…Unilamellar phospholipid vesicles loaded with the water-soluble, ionic X-ray contrast agent diatrizoate (Hypaque, Renografin) were manufactured by…”
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Prostaglandins and cannabis XV. Comparison of enantiomeric cannabinoids in stimulating prostaglandin synthesis in fibroblasts by Burstein, S, Hunter, S A, Latham, V, Mechoulam, R, Melchior, D L, Renzulli, L, Tefft, Jr, R E

“…Stereospecificity has been reported for a number of actions of the cannabinoids in a variety of systems. In the present report, we have shown that this effect…”
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