Search Results - "Melchers, Willem J."

Azole resistance in Aspergillus fumigatus : a side-effect of environmental fungicide use? by Verweij, Paul E, Dr, Snelders, Eveline, MSc, Kema, Gert HJ, PhD, Mellado, Emilia, PhD, Melchers, Willem JG, PhD

“…Summary Invasive aspergillosis due to multi-azole-resistant Aspergillus fumigatus has emerged in the Netherlands since 1999, with 6·0–12·8% of patients…”
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Discovery and characterization of novel Aspergillus fumigatus mycoviruses by Zoll, Jan, Verweij, Paul E, Melchers, Willem J G

“…In the last few years, increasing numbers of viruses infecting fungi have been identified. In this study, we used an in silico approach for the analysis of…”
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Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism by Snelders, Eveline, van der Lee, Henrich A L, Kuijpers, Judith, Rijs, Anthonius J M M, Varga, János, Samson, Robert A, Mellado, Emilia, Donders, A Rogier T, Melchers, Willem J G, Verweij, Paul E

“…Resistance to triazoles was recently reported in Aspergillus fumigatus isolates cultured from patients with invasive aspergillosis. The prevalence of azole…”
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Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles by van der Linden, Jan W. M., Camps, Simone M. T., Kampinga, Greetje A., Arends, Jan P. A., Debets-Ossenkopp, Yvette J., Haas, Pieter J. A., Rijnders, Bart J. A., Kujiper, Ed J., van Tiel, Frank H., Varga, János, Karawajczyk, Anna, Zoll, J., Melchers, Willem J. G., Verweij, Paul E.

“…Background. Azole resistance is an emerging problem in Aspergillus fumigatus and complicates the management of patients with Aspergillus-related diseases…”
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Azole Resistance Profile of Amino Acid Changes in Aspergillus fumigatus CYP51A Based on Protein Homology Modeling by SNELDERS, Eveline, KARAWAJCZYK, Anna, SCHAFTENAAR, Gijs, VERWEIJ, Paul E, MELCHERS, Willem J. G

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Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus by Snelders, Eveline, Camps, Simone M T, Karawajczyk, Anna, Schaftenaar, Gijs, Kema, Gert H J, van der Lee, Henrich A, Klaassen, Corné H, Melchers, Willem J G, Verweij, Paul E

“…Azoles play an important role in the management of Aspergillus diseases. Azole resistance is an emerging global problem in Aspergillus fumigatus, and may…”
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Black Yeasts and Their Filamentous Relatives: Principles of Pathogenesis and Host Defense by SEYEDMOUSAVI, Seyedmojtaba, NETEA, Mihai G, MOUTON, Johan W, MELCHERS, Willem J. G, VERWEIJ, Paul E, DE HOOG, G. Sybren

“…Among the melanized fungi, the so-called "black yeasts" and their filamentous relatives are particularly significant as agents of severe phaeohyphomycosis,…”
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The fading boundaries between patient and environmental routes of triazole resistance selection in Aspergillus fumigatus by Buil, Jochem B, Hare, Rasmus K, Zwaan, Bas J, Arendrup, Maiken C, Melchers, Willem J G, Verweij, Paul E

“…Alternatively, patients may inhale inherently triazole-resistant A. fumigatus spores, supported by the fact that in every case with a wild-type A. fumigatus…”
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Aspergillus Test Profiles and Mortality in Critically Ill COVID-19 Patients by Ergün, Mehmet, Brüggemann, Roger J M, Alanio, Alexandre, Dellière, Sarah, van Arkel, Andreas, Bentvelsen, Robbert G, Rijpstra, Tom, van der Sar-van der Brugge, Simone, Lagrou, Katrien, Janssen, Nico A F, Buil, Jochem B, van Dijk, Karin, Melchers, Willem J G, Reijers, Monique H E, Schouten, Jeroen A, Wauters, Joost, Cordey, Alan, Soni, Shuchita, White, P Lewis, van de Veerdonk, Frank L, Verweij, Paul E

“…The literature regarding COVID-19-associated pulmonary aspergillosis (CAPA) has shown conflicting observations, including survival of CAPA patients not…”
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Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing by Camps, Simone M T, Dutilh, Bas E, Arendrup, Maiken C, Rijs, Antonius J M M, Snelders, Eveline, Huynen, Martijn A, Verweij, Paul E, Melchers, Willem J G

“…Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. However, prolonged treatment may cause resistance to…”
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Possible Environmental Origin of Resistance of Aspergillus fumigatus to Medical Triazoles by Snelders, Eveline, Huis in 't Veld, Robert A.G, Rijs, Anthonius J.M.M, Kema, Gert H.J, Melchers, Willem J.G, Verweij, Paul E

“…We reported the emergence of resistance to medical triazoles of Aspergillus fumigatus isolates from patients with invasive aspergillosis. A dominant resistance…”
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Pharmacodynamics of isavuconazole in an Aspergillus fumigatus mouse infection model by Seyedmousavi, Seyedmojtaba, Brüggemann, Roger J M, Meis, Jacques F, Melchers, Willem J G, Verweij, Paul E, Mouton, Johan W

“…Azole resistance is an emerging problem in Aspergillus fumigatus which translates into treatment failure. Alternative treatments with new azoles may improve…”
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Rapid Induction of Multiple Resistance Mechanisms in Aspergillus fumigatus during Azole Therapy: a Case Study and Review of the Literature by CAMPS, Simone M. T, VAN DER LINDEN, Jan W. M, YI LI, KUIJPER, Ed J, VAN DISSEL, Jaap T, VERWEIJ, Paul E, MELCHERS, Willem J. G

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Temporal composition of the cervicovaginal microbiome associates with hrHPV infection outcomes in a longitudinal study by Molina, Mariano A, Leenders, William P J, Huynen, Martijn A, Melchers, Willem J G, Andralojc, Karolina M

“…Persistent infections with high-risk human papillomavirus (hrHPV) can cause cervical squamous intraepithelial lesions (SIL) that may progress to cancer. The…”
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Whole-Genome Sequencing of Bacterial Pathogens: the Future of Nosocomial Outbreak Analysis by Quainoo, Scott, Coolen, Jordy P M, van Hijum, Sacha A F T, Huynen, Martijn A, Melchers, Willem J G, van Schaik, Willem, Wertheim, Heiman F L

“…Outbreaks of multidrug-resistant bacteria present a frequent threat to vulnerable patient populations in hospitals around the world. Intensive care unit (ICU)…”
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Genetic Diversity and In Vitro Antifungal Susceptibility of 200 Clinical and Environmental Aspergillus flavus Isolates by Taghizadeh-Armaki, Mojtaba, Hedayati, Mohammad Taghi, Ansari, Saham, Omran, Saeed Mahdavi, Saber, Sasan, Rafati, Haleh, Zoll, Jan, van der Lee, Henrich A, Melchers, Willem J G, Verweij, Paul E, Seyedmousavi, Seyedmojtaba

“…has been frequently reported as the leading cause of invasive aspergillosis in certain tropical and subtropical countries. Two hundred strains originating from…”
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Introduction of primary screening using high-risk HPV DNA detection in the Dutch cervical cancer screening programme: a population-based cohort study by Aitken, Clare A, van Agt, Heleen M E, Siebers, Albert G, van Kemenade, Folkert J, Niesters, Hubert G M, Melchers, Willem J G, Vedder, Judith E M, Schuurman, Rob, van den Brule, Adriaan J C, van der Linden, Hans C, Hinrichs, John W J, Molijn, Anco, Hoogduin, Klaas J, van Hemel, Bettien M, de Kok, Inge M C M

“…In January 2017, the Dutch cervical cancer screening programme transitioned from cytomorphological to primary high-risk HPV (hrHPV) DNA screening, including…”
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Impact of the BioFire FilmArray gastrointestinal panel on patient care and infection control by Machiels, Julian D, Cremers, Amelieke J H, van Bergen-Verkuyten, Muriël C G T, Paardekoper-Strijbosch, Sandra J M, Frijns, Kelly C J, Wertheim, Heiman F L, Rahamat-Langendoen, Janette, Melchers, Willem J G

“…Conventional routine PCR testing for gastrointestinal infections is generally based on pathogen related panels specifically requested by clinicians and can be…”
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Evolution of cross-resistance to medical triazoles in Aspergillus fumigatus through selection pressure of environmental fungicides by Zhang, Jianhua, van den Heuvel, Joost, Debets, Alfons J. M., Verweij, Paul E., Melchers, Willem J. G., Zwaan, Bas J., Schoustra, Sijmen E.

“…Resistance to medical triazoles in Aspergillus fumigatus is an emerging problem for patients at risk of aspergillus diseases. There are currently two presumed…”
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Evaluation of Aspergillus PCR Protocols for Testing Serum Specimens by LEWIS WHITE, P, MENGOLI, Carlo, LOEFFLER, Juergen, BRETAGNE, Stephane, CUENCA-ESTRELLA, Manuel, FINNSTROM, Niklas, KLINGSPOR, Lena, MELCHERS, Willem J. G, MCCULLOCH, Elaine, BARNES, Rosemary A, PETER DONNELLY, J

“…OA  Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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