Search Results - "Melchers, Fritz"

The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire by Melchers, Fritz

“…In this Opinion article, I address the role of the pre-B-cell receptor (pre-BCR) in the development of antigen-specific B cells in terms of immunoglobulin…”
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Checkpoints in lymphocyte development and autoimmune disease by Melchers, Fritz, von Boehmer, Harald

“…Antigen receptor–controlled checkpoints in B lymphocyte development are crucial for the prevention of autoimmune diseases such as systemic lupus erythematosus…”
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SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself by Ferreira-Gomes, Marta, Kruglov, Andrey, Durek, Pawel, Heinrich, Frederik, Tizian, Caroline, Heinz, Gitta Anne, Pascual-Reguant, Anna, Du, Weijie, Mothes, Ronja, Fan, Chaofan, Frischbutter, Stefan, Habenicht, Katharina, Budzinski, Lisa, Ninnemann, Justus, Jani, Peter K., Guerra, Gabriela Maria, Lehmann, Katrin, Matz, Mareen, Ostendorf, Lennard, Heiberger, Lukas, Chang, Hyun-Dong, Bauherr, Sandy, Maurer, Marcus, Schönrich, Günther, Raftery, Martin, Kallinich, Tilmann, Mall, Marcus Alexander, Angermair, Stefan, Treskatsch, Sascha, Dörner, Thomas, Corman, Victor Max, Diefenbach, Andreas, Volk, Hans-Dieter, Elezkurtaj, Sefer, Winkler, Thomas H., Dong, Jun, Hauser, Anja Erika, Radbruch, Helena, Witkowski, Mario, Melchers, Fritz, Radbruch, Andreas, Mashreghi, Mir-Farzin

“…The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed…”
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A rheostat sets B-cell receptor repertoire selection to distinguish self from non-self by Jani, Peter K, Kubagawa, Hiromi, Melchers, Fritz

“…•BcRs bind self or non-self antigens with spectra of high to low to no avidities.•A BcR-antigen-IgM-FcμR-rheostat sets PI3K-PTEN balanced B cell…”
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Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019 by Winthrop, Kevin L, Weinblatt, Michael E, Bathon, Joan, Burmester, Gerd R, Mease, Philip J, Crofford, Leslie, Bykerk, Vivian, Dougados, Maxime, Rosenbaum, James Todd, Mariette, Xavier, Sieper, Joachim, Melchers, Fritz, Cronstein, Bruce N, Breedveld, Ferry C, Kalden, Joachim, Smolen, Josef S, Furst, Daniel

“…To detail the greatest areas of unmet scientific and clinical needs in rheumatology. The 21st annual international Advances in Targeted Therapies meeting…”
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MiR221 promotes precursor B‐cell retention in the bone marrow by amplifying the PI3K‐signaling pathway in mice by Petkau, Georg, Kawano, Yohei, Wolf, Ingrid, Knoll, Marko, Melchers, Fritz

“…Hematopoietic stem cells and lineage‐uncommitted progenitors are able to home to the bone marrow upon transplantation and reconstitute the host with…”
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Functional Roles of the IgM Fc Receptor in the Immune System by Kubagawa, Hiromi, Honjo, Kazuhito, Ohkura, Naganari, Sakaguchi, Shimon, Radbruch, Andreas, Melchers, Fritz, Jani, Peter K

“…It is now evident from studies of mice unable to secrete IgM that both non-immune "natural" and antigen-induced "immune" IgM are important for protection…”
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The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes by Jani, Peter K, Petkau, Georg, Kawano, Yohei, Klemm, Uwe, Guerra, Gabriela Maria, Heinz, Gitta Anne, Heinrich, Frederik, Durek, Pawel, Mashreghi, Mir-Farzin, Melchers, Fritz

“…Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM), continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell…”
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Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature by Reismann, David, Stefanowski, Jonathan, Günther, Robert, Rakhymzhan, Asylkhan, Matthys, Romano, Nützi, Reto, Zehentmeier, Sandra, Schmidt-Bleek, Katharina, Petkau, Georg, Chang, Hyun-Dong, Naundorf, Sandra, Winter, York, Melchers, Fritz, Duda, Georg, Hauser, Anja E., Niesner, Raluca A.

“…The bone marrow is a central organ of the immune system, which hosts complex interactions of bone and immune compartments critical for hematopoiesis,…”
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Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis by Tornack, Julia, Reece, Stephen T, Bauer, Wolfgang M, Vogelzang, Alexis, Bandermann, Silke, Zedler, Ulrike, Stingl, Georg, Kaufmann, Stefan H E, Melchers, Fritz

“…An estimated third of the world's population is latently infected with Mycobacterium tuberculosis (Mtb), with no clinical signs of tuberculosis (TB), but…”
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The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling by Ohnishi, Kazuo, Melchers, Fritz

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Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells by Cornelis, Rebecca, Hahne, Stefanie, Taddeo, Adriano, Petkau, Georg, Malko, Darya, Durek, Pawel, Thiem, Manja, Heiberger, Lukas, Peter, Lena, Mohr, Elodie, Klaeden, Cora, Tokoyoda, Koji, Siracusa, Francesco, Hoyer, Bimba Franziska, Hiepe, Falk, Mashreghi, Mir-Farzin, Melchers, Fritz, Chang, Hyun-Dong, Radbruch, Andreas

“…The persistence of long-lived memory plasma cells in the bone marrow depends on survival factors available in the bone marrow, which are provided in niches…”
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Functions of IgM fc receptor (FcµR) related to autoimmunity by Kubagawa, Hiromi, Mahmoudi Aliabadi, Pedram, Al-Qaisi, Khlowd, Jani, Peter K, Honjo, Kazuhito, Izui, Shozo, Radbruch, Andreas, Melchers, Fritz

“…Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR…”
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Physiological and Pathophysiological Roles of IgM Fc Receptor (FcµR) Isoforms by Kubagawa, Hiromi, Clark, Caren, Skopnik, Christopher M, Mahmoudi Aliabadi, Pedram, Al-Qaisi, Khlowd, Teuber, Ruth, Jani, Peter K, Radbruch, Andreas, Melchers, Fritz, Engels, Niklas, Wienands, Jürgen

“…IgM is the first antibody to emerge during phylogeny, ontogeny, and immune responses and serves as a first line of defense. Effector proteins interacting with…”
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Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow by Ferreira-Gomes, Marta, Chen, Yidan, Durek, Pawel, Rincon-Arevalo, Hector, Heinrich, Frederik, Bauer, Laura, Szelinski, Franziska, Guerra, Gabriela Maria, Stefanski, Ana-Luisa, Niedobitek, Antonia, Wiedemann, Annika, Bondareva, Marina, Ritter, Jacob, Lehmann, Katrin, Hardt, Sebastian, Hipfl, Christian, Hein, Sascha, Hildt, Eberhard, Matz, Mareen, Mei, Henrik E., Cheng, Qingyu, Dang, Van Duc, Witkowski, Mario, Lino, Andreia C., Kruglov, Andrey, Melchers, Fritz, Perka, Carsten, Schrezenmeier, Eva V., Hutloff, Andreas, Radbruch, Andreas, Dörner, Thomas, Mashreghi, Mir-Farzin

“…Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC…”
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Checkpoints that control B cell development by Melchers, Fritz

“…B cells differentiate from pluripotent hematopoietic stem cells (pHSCs) in a series of distinct stages. During early embryonic development, pHSCs migrate into…”
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IL‐7 and immobilized Kit‐ligand stimulate serum‐ and stromal cell‐free cultures of precursor B‐cell lines and clones by Kawano, Yohei, Petkau, Georg, Wolf, Ingrid, Tornack, Julia, Melchers, Fritz

“…Long‐term proliferating, DHJH‐rearranged mouse precursor B‐cell lines have previously been established in serum‐ and IL‐7‐containing media from fetal liver,…”
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Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal Antibody by Mahmoudi Aliabadi, Pedram, Teuber, Ruth, Jani, Peter K., Wilson, Landon, Enghard, Philipp, Barnes, Stephen, Chiorazzi, Nicholas, Radbruch, Andreas, Melchers, Fritz, Kubagawa, Hiromi

“…The FcR for IgM (FcµR) is the newest member of the FcR family, selectively expressed by lymphocytes, and distinct from FcRs for switched Ig isotypes that are…”
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Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors by Kawano, Yohei, Petkau, Georg, Stehle, Christina, Durek, Pawel, Heinz, Gitta Anne, Tanimoto, Kousuke, Karasuyama, Hajime, Mashreghi, Mir-Farzin, Romagnani, Chiara, Melchers, Fritz

“…Common lymphoid progenitors (CLPs) differentiate to T and B lymphocytes, dendritic cells, natural killer cells, and innate lymphoid cells. Here, we describe…”
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Flt3 ligand‐eGFP‐reporter expression characterizes functionally distinct subpopulations of CD150+ long‐term repopulating murine hematopoietic stem cells by Tornack, Julia, Kawano, Yohei, Garbi, Natalio, Hämmerling, Günter J., Melchers, Fritz, Tsuneto, Motokazu

“…The pool of hematopoietic stem cells (HSCs) in the bone marrow is a mixture of resting, proliferating, and differentiating cells. Long‐term repopulating HSCs…”
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