Search Results - "Melcher, Alan"

Oncolytic virotherapy as immunotherapy by Melcher, Alan, Harrington, Kevin, Vile, Richard

“…Recognizing immune responses to oncolytic virotherapy opens the way for new combinations…”
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Inflammatory microenvironment remodelling by tumour cells after radiotherapy by McLaughlin, Martin, Patin, Emmanuel C., Pedersen, Malin, Wilkins, Anna, Dillon, Magnus T., Melcher, Alan A., Harrington, Kevin J.

“…The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think about cancer treatment. Even so, for most types of cancer, only a…”
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Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade by Samson, Adel, Scott, Karen J, Taggart, David, West, Emma J, Wilson, Erica, Nuovo, Gerard J, Thomson, Simon, Corns, Robert, Mathew, Ryan K, Fuller, Martin J, Kottke, Timothy J, Thompson, Jill M, Ilett, Elizabeth J, Cockle, Julia V, van Hille, Philip, Sivakumar, Gnanamurthy, Polson, Euan S, Turnbull, Samantha J, Appleton, Elizabeth S, Migneco, Gemma, Rose, Ailsa S, Coffey, Matthew C, Beirne, Deborah A, Collinson, Fiona J, Ralph, Christy, Alan Anthoney, D, Twelves, Christopher J, Furness, Andrew J, Quezada, Sergio A, Wurdak, Heiko, Errington-Mais, Fiona, Pandha, Hardev, Harrington, Kevin J, Selby, Peter J, Vile, Richard G, Griffin, Stephen D, Stead, Lucy F, Short, Susan C, Melcher, Alan A

“…Immune checkpoint inhibitors, including those targeting programmed cell death protein 1 (PD-1), are reshaping cancer therapeutic strategies. Evidence suggests,…”
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The immunological consequences of radiation‐induced DNA damage by Wilkins, Anna C, Patin, Emmanuel C, Harrington, Kevin J, Melcher, Alan A

“…Historically, our understanding of the cytotoxicity of radiation has centred on tumour cell‐autonomous mechanisms of cell death. Here, tumour cell death occurs…”
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Phase I Trial of an ICAM-1-Targeted Immunotherapeutic-Coxsackievirus A21 (CVA21) as an Oncolytic Agent Against Non Muscle-Invasive Bladder Cancer by Annels, Nicola E, Mansfield, David, Arif, Mehreen, Ballesteros-Merino, Carmen, Simpson, Guy R, Denyer, Mick, Sandhu, Sarbjinder S, Melcher, Alan A, Harrington, Kevin J, Davies, Bronwyn, Au, Gough, Grose, Mark, Bagwan, Izhar, Fox, Bernard, Vile, Richard, Mostafid, Hugh, Shafren, Darren, Pandha, Hardev S

“…The CANON [ VATAK in -muscle-invasive bladder cancer (NMIBC)] study evaluated a novel ICAM-1-targeted immunotherapeutic-coxsackievirus A21 as a novel oncolytic…”
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Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity by Wilson, Erica B, El-Jawhari, Jehan J, Neilson, Abbie L, Hall, Geoffrey D, Melcher, Alan A, Meade, Josephine L, Cook, Graham P

“…Immune evasion is now recognized as a key feature of cancer progression. In animal models, the activity of cytotoxic lymphocytes is suppressed in the tumour…”
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ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment by Dillon, Magnus T, Bergerhoff, Katharina F, Pedersen, Malin, Whittock, Harriet, Crespo-Rodriguez, Eva, Patin, Emmanuel C, Pearson, Alex, Smith, Henry G, Paget, James T E, Patel, Radhika R, Foo, Shane, Bozhanova, Galabina, Ragulan, Chanthirika, Fontana, Elisa, Desai, Krisha, Wilkins, Anna C, Sadanandam, Anguraj, Melcher, Alan, McLaughlin, Martin, Harrington, Kevin J

“…ATR inhibitors (ATRi) are in early phase clinical trials and have been shown to sensitize to chemotherapy and radiotherapy preclinically. Limited data have…”
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Glycolysis and Fatty Acid Oxidation Inhibition Improves Survival in Glioblastoma by McKelvey, Kelly J, Wilson, Erica B, Short, Susan, Melcher, Alan A, Biggs, Michael, Diakos, Connie I, Howell, Viive M

“…Glioblastoma (GBM) is the most aggressive adult glioma with a median survival of 14 months. While standard treatments (safe maximal resection, radiation, and…”
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Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy by Chan Wah Hak, Charleen M L, Rullan, Antonio, Patin, Emmanuel C, Pedersen, Malin, Melcher, Alan A, Harrington, Kevin J

“…Radiotherapy is one of the most effective and frequently used treatments for a wide range of cancers. In addition to its direct anti-cancer cytotoxic effects,…”
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Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy by Patin, Emmanuel C., Nenclares, Pablo, Chan Wah Hak, Charleen, Dillon, Magnus T., Patrikeev, Anton, McLaughlin, Martin, Grove, Lorna, Foo, Shane, Soliman, Heba, Barata, Joao P., Marsden, Joanna, Baldock, Holly, Gkantalis, Jim, Roulstone, Victoria, Kyula, Joan, Burley, Amy, Hubbard, Lisa, Pedersen, Malin, Smith, Simon A., Clancy-Thompson, Eleanor, Melcher, Alan A., Ono, Masahiro, Rullan, Antonio, Harrington, Kevin J.

“…The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck…”
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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study by Punta, Marco, Jennings, Victoria A, Melcher, Alan A, Lise, Stefano

“…Cancer somatic mutations have been identified as a source of antigens that can be targeted by cancer immunotherapy. In this work, expanding on previous…”
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Cell Carriers for Oncolytic Viruses: Fed Ex for Cancer Therapy by Willmon, Candice, Harrington, Kevin, Kottke, Timothy, Prestwich, Robin, Melcher, Alan, Vile, Richard

“…Oncolytic viruses delivered directly into the circulation face many hazards that impede their localization to, and infection of, metastatic tumors. Such…”
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Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition by Jennings, Victoria A., Scott, Gina B., Rose, Ailsa M.S., Scott, Karen J., Migneco, Gemma, Keller, Brian, Reilly, Katrina, Donnelly, Oliver, Peach, Howard, Dewar, Donald, Harrington, Kevin J., Pandha, Hardev, Samson, Adel, Vile, Richard G., Melcher, Alan A., Errington-Mais, Fiona

“…A clinical oncolytic herpes simplex virus (HSV) encoding granulocyte-macrophage colony-stimulating factor (GM-CSF), talimogene laherparepvec, causes regression…”
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Kickstarting Immunity in Cold Tumours: Localised Tumour Therapy Combinations With Immune Checkpoint Blockade by Appleton, Elizabeth, Hassan, Jehanne, Chan Wah Hak, Charleen, Sivamanoharan, Nanna, Wilkins, Anna, Samson, Adel, Ono, Masahiro, Harrington, Kevin J, Melcher, Alan, Wennerberg, Erik

“…Cancer patients with low or absent pre-existing anti-tumour immunity ("cold" tumours) respond poorly to treatment with immune checkpoint inhibitors (ICPI). In…”
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Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade by Patin, Emmanuel C, Dillon, Magnus T, Nenclares, Pablo, Grove, Lorna, Soliman, Heba, Leslie, Isla, Northcote, Davina, Bozhanova, Galabina, Crespo-Rodriguez, Eva, Baldock, Holly, Whittock, Harriet, Baker, Gabriella, Kyula, Joan, Guevara, Jeane, Melcher, Alan A, Harper, James, Ghadially, Hormas, Smith, Simon, Pedersen, Malin, McLaughlin, Martin, Harrington, Kevin J

“…BackgroundDespite therapeutic gains from immune checkpoint inhibitors (ICI) in many tumor types, new strategies are needed to extend treatment benefits,…”
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APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy by Driscoll, Christopher B., Schuelke, Matthew R., Kottke, Timothy, Thompson, Jill M., Wongthida, Phonphimon, Tonne, Jason M., Huff, Amanda L., Miller, Amber, Shim, Kevin G., Molan, Amy, Wetmore, Cynthia, Selby, Peter, Samson, Adel, Harrington, Kevin, Pandha, Hardev, Melcher, Alan, Pulido, Jose S., Harris, Reuben, Evgin, Laura, Vile, Richard G.

“…APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance…”
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The case of oncolytic viruses versus the immune system: waiting on the judgment of Solomon by Prestwich, Robin J, Errington, Fiona, Diaz, Rosa M, Pandha, Hardev S, Harrington, Kevin J, Melcher, Alan A, Vile, Richard G

“…The three-way interaction between oncolytic viruses, the tumor microenvironment, and the immune system is critical to the outcome of antitumor therapy…”
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Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies by KARAPANAGIOTOU, Eleni M, ROULSTONE, Victoria, COFFEY, Matt, THOMPSON, Brad, METTINGER, Karl, VILE, Richard G, PANDHA, Hardev S, HALL, Geoff D, MELCHER, Alan A, CHESTER, John, HARRINGTON, Kevin J, TWIGGER, Katie, BALL, Mercel, TANAY, Maryanne, NUTTING, Chris, NEWBOLD, Kate, GORE, Martin E, LARKIN, James, SYRIGOS, Konstantinos N

“…Reovirus type 3 Dearing (RT3D) replicates preferentially in Ras-activated cancers. RT3D shows synergistic in vitro cytotoxicity in combination with platins and…”
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Expression of tumor antigens within an oncolytic virus enhances the anti-tumor T cell response by Webb, Mason J., Sangsuwannukul, Thanich, van Vloten, Jacob, Evgin, Laura, Kendall, Benjamin, Tonne, Jason, Thompson, Jill, Metko, Muriel, Moore, Madelyn, Chiriboga Yerovi, Maria P., Olin, Michael, Borgatti, Antonella, McNiven, Mark, Monga, Satdarshan P. S., Borad, Mitesh J., Melcher, Alan, Roberts, Lewis R., Vile, Richard

“…Although patients benefit from immune checkpoint inhibition (ICI) therapy in a broad variety of tumors, resistance may arise from immune suppressive tumor…”
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Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients by Adair, Robert A, Roulstone, Victoria, Scott, Karen J, Morgan, Ruth, Nuovo, Gerard J, Fuller, Martin, Beirne, Deborah, West, Emma J, Jennings, Victoria A, Rose, Ailsa, Kyula, Joan, Fraser, Sheila, Dave, Rajiv, Anthoney, David A, Merrick, Alison, Prestwich, Robin, Aldouri, Amer, Donnelly, Oliver, Pandha, Hardev, Coffey, Matt, Selby, Peter, Vile, Richard, Toogood, Giles, Harrington, Kevin, Melcher, Alan A

“…Oncolytic viruses, which preferentially lyse cancer cells and stimulate an antitumor immune response, represent a promising approach to the treatment of…”
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