Search Results - "Melas, Catherine"

An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer by Chtarto, Abdelwahed, Bockstael, Olivier, Gebara, Elias, Vermoesen, Katia, Melas, Catherine, Pythoud, Catherine, Levivier, Marc, De Witte, Olivier, Luthi-Carter, Ruth, Clinkers, Ralph, Tenenbaum, Liliane

“…Stimulation of resident cells by NF-κB activating cytokines is a central element of inflammatory and degenerative disorders of the central nervous system…”
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A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses by Chtarto, Abdelwahed, Humbert-Claude, Marie, Bockstael, Olivier, Das, Atze T, Boutry, Sébastien, Breger, Ludivine S, Klaver, Bep, Melas, Catherine, Barroso-Chinea, Pedro, Gonzalez-Hernandez, Tomas, Muller, Robert N, DeWitte, Olivier, Levivier, Marc, Lundberg, Cecilia, Berkhout, Ben, Tenenbaum, Liliane

“…Preclinical and clinical data stress the importance of pharmacologically-controlling glial cell line-derived neurotrophic factor (GDNF) intracerebral…”
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Rapid transgene expression in multiple precursor cell types of adult rat subventricular zone mediated by adeno-associated type 1 vectors by Bockstael, Olivier, Melas, Catherine, Pythoud, Catherine, Levivier, Marc, McCarty, Douglas, Samulski, R Jude, De Witte, Olivier, Tenenbaum, Liliane

“…The adult rat brain subventricular zone (SVZ) contains proliferative precursors that migrate to the olfactory bulb (OB) and differentiate into mature neurons…”
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Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material by Lock, Martin, McGorray, Susan, Auricchio, Alberto, Ayuso, Eduard, Beecham, E Jeffrey, Blouin-Tavel, Véronique, Bosch, Fatima, Bose, Mahuya, Byrne, Barry J, Caton, Tina, Chiorini, John A, Chtarto, Abdelwahed, Clark, K Reed, Conlon, Thomas, Darmon, Christophe, Doria, Monica, Douar, Anne, Flotte, Terence R, Francis, Joyce D, Francois, Achille, Giacca, Mauro, Korn, Michael T, Korytov, Irina, Leon, Xavier, Leuchs, Barbara, Lux, Gabriele, Melas, Catherine, Mizukami, Hiroaki, Moullier, Philippe, Müller, Marcus, Ozawa, Keiya, Philipsberg, Tina, Poulard, Karine, Raupp, Christina, Rivière, Christel, Roosendaal, Sigrid D, Samulski, R Jude, Soltys, Steven M, Surosky, Richard, Tenenbaum, Liliane, Thomas, Darby L, van Montfort, Bart, Veres, Gabor, Wright, J Fraser, Xu, Yili, Zelenaia, Olga, Zentilin, Lorena, Snyder, Richard O

“…A recombinant adeno-associated virus serotype 2 Reference Standard Material (rAAV2 RSM) has been produced and characterized with the purpose of providing a…”
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Intracisternal delivery of NFκB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment by Bockstael, Olivier, Tenenbaum, Liliane, Dalkara, Deniz, Melas, Catherine, De Witte, Olivier, Levivier, Marc, Chtarto, Abdelwahed

“…We have previously demonstrated disease-dependent gene delivery in the brain using an AAV vector responding to NFκB activation as a probe for inflammatory…”
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Intracisternal delivery of NFκB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment by Bockstael, Olivier, Tenenbaum, Liliane, Dalkara, Deniz, Melas, Catherine, De Witte, Olivier, Levivier, Marc, Chtarto, Abdelwahed

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An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-[kappa]B Activation for Disease-Inducible Gene Transfer by Chtarto, Abdelwahed, Bockstael, Olivier, Gebara, Elias, Vermoesen, Katia, Melas, Catherine, Pythoud, Catherine, Levivier, Marc, De Witte, Olivier, Luthi-Carter, Ruth, Clinkers, Ralph, Tenenbaum, Liliane

“…Stimulation of resident cells by NF-[kappa]B activating cytokines is a central element of inflammatory and degenerative disorders of the central nervous system…”
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Differential transgene expression profiles in rat brain, using rAAV2/1 vectors with tetracycline-inducible and cytomegalovirus promoters by Bockstael, Olivier, Chtarto, Abdelwahed, Wakkinen, Janica, Yang, Xin, Melas, Catherine, Levivier, Marc, Brotchi, Jacques, Tenenbaum, Liliane

“…The biodistribution of transgene expression in the CNS after localized stereotaxic vector delivery is an important issue for the safety of gene therapy for…”
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641. Tetracycline-Inducible Human GDNF Expression Mediated by a Single AAV Vector by Chtarto, Abdelwahed, Melas, Catherine, Blum, David, Jaspar, Jean-marie, Velu, Thierry, Brotchi, Jacques, Levivier, Marc, Tenenbaum, Liliane

“…Neuroprotective gene therapy for Parkinson's disease, consisting in GDNF gene transfer into the striatum has been proposed using various viral vectors…”
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