Search Results - "Melamed, Rachel D."

Shared etiology of Mendelian and complex disease supports drug discovery by Lalagkas, Panagiotis N, Melamed, Rachel D

“…Drugs targeting disease causal genes are more likely to succeed for that disease. However, complex disease causal genes are not always clear. In contrast,…”
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Shared genetics between breast cancer and predisposing diseases identifies novel breast cancer treatment candidates by Lalagkas, Panagiotis N., Melamed, Rachel D.

“…Abstract Background Current effective breast cancer treatment options have severe side effects, highlighting a need for new therapies. Drug repurposing can…”
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Patchwork of contrasting medication cultures across the USA by Melamed, Rachel D., Rzhetsky, Andrey

“…Health in the United States is markedly heterogeneous, with large disparities in disease incidence, treatment choices and health spending. Drug prescription is…”
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FBXW7 Mutations in Melanoma and a New Therapeutic Paradigm by AYDIN, Iraz T, MELAMED, Rachel D, CELEBI, Julide Tok, ADAMS, Sarah J, CASTILLO-MARTIN, Mireia, DEMIR, Ahu, BRYK, Diana, BRUNNER, Georg, CORDON-CARDO, Carlos, OSMAN, Iman, RABADAN, Raul

“…Melanoma is a heterogeneous tumor with subgroups requiring distinct therapeutic strategies. Genetic dissection of melanoma subgroups and identification of…”
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Data-driven discovery of seasonally linked diseases from an Electronic Health Records system by Melamed, Rachel D, Khiabanian, Hossein, Rabadan, Raul

“…Patterns of disease incidence can identify new risk factors for the disease or provide insight into the etiology. For example, allergies and infectious…”
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Reduction of Phosphorylated Tau in Alzheimer's Disease Induced Pluripotent Stem Cell-Derived Neuro-Spheroids by Rho-Associated Coiled-Coil Kinase Inhibitor Fasudil by Giunti, Elisa, Collu, Roberto, Daley, Sarah, Querfurth, Henry, Morin, Peter, Killick, Richard, Melamed, Rachel D, Xia, Weiming

“…Alzheimer's disease (AD) is the most predominant form of dementia. Rho-associated coiled coil kinase (ROCK) inhibitor, fasudil, is one of the candidate drugs…”
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Using indication embeddings to represent patient health for drug safety studies by Melamed, Rachel D

“…The electronic health record is a rising resource for quantifying medical practice, discovering the adverse effects of drugs, and studying comparative…”
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Genomic Characterization of Dysplastic Nevi Unveils Implications for Diagnosis of Melanoma by Melamed, Rachel D., Aydin, Iraz T., Rajan, Geena Susan, Phelps, Robert, Silvers, David N., Emmett, Kevin J., Brunner, Georg, Rabadan, Raul, Celebi, Julide Tok

“…A well-defined risk factor and precursor for cutaneous melanoma is the dysplastic nevus. These benign tumors represent clonal hyperproliferation of melanocytes…”
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Genetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes by Melamed, Rachel D., Emmett, Kevin J., Madubata, Chioma, Rzhetsky, Andrey, Rabadan, Raul

“…Despite large-scale cancer genomics studies, key somatic mutations driving cancer, and their functional roles, remain elusive. Here, we propose that analysis…”
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Mapping drug biology to disease genetics to discover drug impacts on the human phenome by Habib, Mamoon, Lalagkas, Panagiotis Nikolaos, Melamed, Rachel D

“…Medications can have unexpected effects on disease, including not only harmful drug side effects, but also beneficial drug repurposing. These effects on…”
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Associations Between Natural Language Processing-Enriched Social Determinants of Health and Suicide Death Among US Veterans by Mitra, Avijit, Pradhan, Richeek, Melamed, Rachel D, Chen, Kun, Hoaglin, David C, Tucker, Katherine L, Reisman, Joel I, Yang, Zhichao, Liu, Weisong, Tsai, Jack, Yu, Hong

“…Social determinants of health (SDOHs) are known to be associated with increased risk of suicidal behaviors, but few studies use SDOHs from unstructured…”
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An information theoretic method to identify combinations of genomic alterations that promote glioblastoma by Melamed, Rachel D, Wang, Jiguang, Iavarone, Antonio, Rabadan, Raul

“…Tumors are the result of accumulated genomic alterations that cooperate synergistically to produce uncontrollable cell growth. Although identifying recurrent…”
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GAB2 induces tumor angiogenesis in NRAS-driven melanoma by Yang, Y, Wu, J, Demir, A, Castillo-Martin, M, Melamed, R D, Zhang, G, Fukunaga-Kanabis, M, Perez-Lorenzo, R, Zheng, B, Silvers, D N, Brunner, G, Wang, S, Rabadan, R, Cordon-Cardo, C, Celebi, J T

“…GAB2 is a scaffold protein with diverse upstream and downstream effectors. MAPK and PI3K signaling pathways are known effectors of GAB2. It is amplified and…”
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Mining patterns in genomic and clinical cancer data to characterize novel driver genes by Melamed, Rachel D

“…Cancer research, like many areas of science, is adapting to a new era characterized by increasing quantity, quality, and diversity of observational data. An…”
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Associations Between Natural Language Processing (NLP) Enriched Social Determinants of Health and Suicide Death among US Veterans by Mitra, Avijit, Pradhan, Richeek, Melamed, Rachel D, Chen, Kun, Hoaglin, David C, Tucker, Katherine L, Reisman, Joel I, Yang, Zhichao, Liu, Weisong, Tsai, Jack, Yu, Hong

“…Importance: Social determinants of health (SDOH) are known to be associated with increased risk of suicidal behaviors, but few studies utilized SDOH from…”
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Mining patterns in genomic and clinical cancer data to characterize novel driver genes by Melamed, Rachel D

“…Cancer research, like many areas of science, is adapting to a new era characterized by increasing quantity, quality, and diversity of observational data. An…”
Get full text