Search Results - "Meko, Jennifer B"

Immune Response Against Large Tumors Eradicated by Treatment with Cyclophosphamide and IL-12 by Tsung, Kangla, Meko, Jennifer B, Tsung, Ying L, Peplinski, Gary R, Norton, Jeffrey A

“…Previous studies have demonstrated eradication of small (4-8 mm) established murine MCA207 sarcomas by treatment with systemic IL-12. Analysis of the mechanism…”
Get full text

High cytokine production and effective antitumor activity of a recombinant vaccinia virus encoding murine interleukin 12 by MEKO, J. B, YIM, J. H, KANGLA TSUNG, NORTON, J. A

“…We have constructed a recombinant vaccinia virus (recVV), vKT0334 mIL-12, containing the genes encoding the p35 and p40 subunits of murine interleukin-12…”
Get full text

IL-12 induces T helper 1-directed antitumor response by Tsung, K, Meko, JB, Peplinski, GR, Tsung, YL, Norton, JA

“…Although IL-12 possesses the most potent single-cytokine antitumor efficacy, the mechanism by which IL-12 exerts its antitumor activities remains unclear…”
Get full text

Large cystic/solid thyroid nodules: A potential false-negative fine-needle aspiration by Meko, Jennifer B., Norton, Jeffrey A.

“…Background. False-negative fine-needle aspiration (FNA) biopsy results of thyroid nodules are of particular concern because they imply missed malignant…”
Get full text

Evaluation of somatostatin-receptor scintigraphy for detecting neuroendocrine tumors by Meko, Jennifer B., Doherty, Gerard M., Siegel, Barry A., Norton, Jeffrey A.

“…Background. Somatostatin-receptor scintigraphy (SRS) has gained attention as an imaging modality for neuroendocrine tumors (NETs). The purpose of this study…”
Get full text

In vivo gene therapy of a murine pancreas tumor with recombinant vaccinia virus encoding human interleukin-1beta by Peplinski, Gary R., Tsung, Kangla, Meko, Jennifer B., Norton, Jeffrey A.

“…Background. Recombinant vaccinia virus (VV) encoding human interleukin-1β (vMJ601hIL-1β) given intravenously persists in tumor tissue and expresses hIL-1β for…”
Get full text

Cytokine production and antitumor effect of a nonreplicating, noncytopathic recombinant vaccinia virus expressing interleukin-12 by Meko, Jennifer B., Tsung, Kangla, Norton, Jeffrey A.

“…Background. Cancer gene therapy with interleukin-12 (IL-12) has generated much interest because of the potent antitumor effects of this cytokine. The purpose…”
Get full text

Prevention of murine breast cancer by vaccination with tumor cells modified by cytokine-producing recombinant vaccinia viruses by Peplinski, G R, Tsung, K, Meko, J B, Norton, J A

“…Cancer gene therapy expressing specific levels of multiple genes has not been adequately tested. This study investigates the antitumor effects of recombinant…”
Get full text

Induction of antigen-presenting capacity in tumor cells upon infection with non-replicating recombinant vaccinia virus encoding murine MHC class II and costimulatory molecules by Marti, Walter R., Oertli, Daniel, Meko, Jennifer B., Norton, Jeffrey A., Tsung, Kangla

“…The possibility of inducing antigen-presenting capacity in cells normally lacking such capacity, currently represents a major goal in vaccine research. To…”
Get full text

Construction and expression in tumor cells of a recombinant vaccinia virus encoding human interleukin-1 beta by Peplinski, G R, Tsung, K, Whitman, E D, Meko, J B, Norton, J A

“…Human interleukin-1 beta (hIL-1 beta) injected intratumorally has demonstrated growth inhibition of transplanted subcutaneous tumors in mice, regression of…”
Get full text

Prevention of murine breast cancer by vaccination with tumor cells modified by cytokine-producing recombinant vaccinia viruses by Peplinski, Gary R., Tsung, Kangla, Meko, Jennifer B., Norton, Jeffrey A.

Get full text