Search Results - "Mekle, Ralf"

Evolution of Blood-Brain Barrier Permeability in Subacute Ischemic Stroke and Associations With Serum Biomarkers and Functional Outcome by Müller, Sarah, Kufner, Anna, Dell'Orco, Andrea, Rackoll, Torsten, Mekle, Ralf, Piper, Sophie K., Fiebach, Jochen B., Villringer, Kersten, Flöel, Agnes, Endres, Matthias, Ebinger, Martin, Nave, Alexander H.

“…Background and Purpose: In the setting of acute ischemic stroke, increased blood-brain barrier permeability (BBBP) as a sign of injury is believed to be…”
Get full text

Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations by Harris, Ashley D, Amiri, Houshang, Bento, Mariana, Cohen, Ronald, Ching, Christopher R K, Cudalbu, Christina, Dennis, Emily L, Doose, Arne, Ehrlich, Stefan, Kirov, Ivan I, Mekle, Ralf, Oeltzschner, Georg, Porges, Eric, Souza, Roberto, Tam, Friederike I, Taylor, Brian, Thompson, Paul M, Quidé, Yann, Wilde, Elisabeth A, Williamson, John, Lin, Alexander P, Bartnik-Olson, Brenda

“…Magnetic resonance spectroscopy is a powerful, non-invasive, quantitative imaging technique that allows for the measurement of brain metabolites that has…”
Get full text

Advanced single voxel 1H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations by Öz, Gülin, Deelchand, Dinesh K., Wijnen, Jannie P., Mlynárik, Vladimír, Xin, Lijing, Mekle, Ralf, Noeske, Ralph, Scheenen, Tom W.J., Tkáč, Ivan, Andronesi, Ovidiu, Barker, Peter B., Bartha, Robert, Berrington, Adam, Boer, Vincent, Cudalbu, Christina, Emir, Uzay E., Ernst, Thomas, Fillmer, Ariane, Heerschap, Arend, Henry, Pierre‐Gilles, Hurd, Ralph E., Joers, James M., Juchem, Christoph, Kan, Hermien E., Klomp, Dennis W. J., Kreis, Roland, Landheer, Karl, Mangia, Silvia, Marjańska, Małgorzata, Near, Jamie, Ratai, Eva M., Ronen, Itamar, Slotboom, Johannes, Soher, Brian J., Terpstra, Melissa, Valette, Julien, Van der Graaf, Marinette, Wilson, Martin

“…Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite…”
Get full text

Functional Brain Changes Due to Chronic Abdominal Pain in Inflammatory Bowel Disease: A Case-Control Magnetic Resonance Imaging Study by Prüß, Magdalena S., Bayer, Arian, Bayer, Kian-Elias, Schumann, Michael, Atreya, Raja, Mekle, Ralf, Fiebach, Jochen B., Siegmund, Britta, Neeb, Lars

“…Various chronic pain conditions go along with functional and structural brain changes. This study aimed to investigate functional and structural brain changes…”
Get full text

Differentiation of Cerebral Neoplasms with Vessel Size Imaging (VSI) by Foda, Asmaa, Kellner, Elias, Gunawardana, Asanka, Gao, Xiang, Janz, Martin, Kufner, Anna, Khalil, Ahmed A., Geran, Rohat, Mekle, Ralf, Fiebach, Jochen B., Galinovic, Ivana

“…Purpose Cerebral neoplasms of various histological origins may show comparable appearances on conventional Magnetic Resonance Imaging (MRI). Vessel size…”
Get full text

Glutamate Concentration in the Superior Temporal Sulcus Relates to Neuroticism in Schizophrenia by Balz, Johanna, Roa Romero, Yadira, Keil, Julian, Schubert, Florian, Ittermann, Bernd, Mekle, Ralf, Montag, Christiane, Gallinat, Jürgen, Senkowski, Daniel

“…Clinical studies suggest aberrant neurotransmitter concentrations in the brains of patients with schizophrenia (SCZ). Numerous studies have indicated deviant…”
Get full text

Initial In Vivo Studies with a Polymer-based MR-compatible Guide Wire by Mekle, Ralf, PhD, Zenge, Michael O., PhD, Ladd, Mark E., PhD, Quick, Harald H., PhD, Hofmann, Eugen, Scheffler, Klaus, PhD, Bilecen, Deniz, MD, PhD

“…The purpose of this study was to evaluate a new polymer-based and magnetic resonance (MR) imaging–compatible guide wire for its application in MR-guided…”
Get full text

MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T by Mekle, Ralf, Mlynárik, Vladimír, Gambarota, Giulio, Hergt, Martin, Krueger, Gunnar, Gruetter, Rolf

“…Recently, the spin‐echo full‐intensity acquired localized (SPECIAL) spectroscopy technique was proposed to unite the advantages of short TEs on the order of…”
Get full text

Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla by Schaller, Benoît, Mekle, Ralf, Xin, Lijing, Kunz, Nicolas, Gruetter, Rolf

“…After the landmark studies reporting changes in the cerebral metabolic rate of glucose (CMRGlc) in excess of those in oxygen (CMRO2) during physiological…”
Get full text

T 2 relaxation times of macromolecules and metabolites in the human brain at 9.4 T by Murali-Manohar, Saipavitra, Borbath, Tamas, Wright, Andrew Martin, Soher, Brian, Mekle, Ralf, Henning, Anke

“…Relaxation times can contribute to spectral assignment. In this study, effective T relaxation times ( ) of macromolecules are reported for gray and white…”
Get full text

T2 relaxation times of macromolecules and metabolites in the human brain at 9.4 T by Murali‐Manohar, Saipavitra, Borbath, Tamas, Wright, Andrew Martin, Soher, Brian, Mekle, Ralf, Henning, Anke

“…Purpose Relaxation times can contribute to spectral assignment. In this study, effective T2 relaxation times (T2eff) of macromolecules are reported for gray…”
Get full text

Unedited in vivo detection and quantification of γ-aminobutyric acid in the occipital cortex using short-TE MRS at 3 T by Near, Jamie, Andersson, Jesper, Maron, Eduard, Mekle, Ralf, Gruetter, Rolf, Cowen, Philip, Jezzard, Peter

“…Short‐TE MRS has been proposed recently as a method for the in vivo detection and quantification of γ‐aminobutyric acid (GABA) in the human brain at 3 T. In…”
Get full text

GABA concentration in superior temporal sulcus predicts gamma power and perception in the sound-induced flash illusion by Balz, Johanna, Keil, Julian, Roa Romero, Yadira, Mekle, Ralf, Schubert, Florian, Aydin, Semiha, Ittermann, Bernd, Gallinat, Jürgen, Senkowski, Daniel

“…In everyday life we are confronted with inputs of multisensory stimuli that need to be integrated across our senses. Individuals vary considerably in how they…”
Get full text

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis by Xin, Lijing, Mekle, Ralf, Fournier, Margot, Baumann, Philipp S, Ferrari, Carina, Alameda, Luis, Jenni, Raoul, Lu, Huanxiang, Schaller, Benoit, Cuenod, Michel, Conus, Philippe, Gruetter, Rolf, Do, Kim Q

“…Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR)…”
Get full text

Metabolite‐cycled STEAM and semi‐LASER localization for MR spectroscopy of the human brain at 9.4T by Giapitzakis, Ioannis‐Angelos, Shao, Tingting, Avdievich, Nikolai, Mekle, Ralf, Kreis, Roland, Henning, Anke

“…Purpose Metabolite cycling (MC) is an MRS technique for the simultaneous acquisition of water and metabolite spectra that avoids chemical exchange saturation…”
Get full text

Fourier‐based decomposition for simultaneous 2‐voxel MRS acquisition with 2SPECIAL by Riemann, Layla Tabea, Aigner, Christoph Stefan, Mekle, Ralf, Speck, Oliver, Rose, Georg, Ittermann, Bernd, Schmitter, Sebastian, Fillmer, Ariane

“…Purpose To simultaneously acquire spectroscopic signals from two MRS voxels using a multi‐banded 2 spin‐echo, full‐intensity acquired localized (2SPECIAL)…”
Get full text

Reproducibility of cerebral perfusion measurements using BOLD delay by Khalil, Ahmed A., Tanritanir, Ayse C., Grittner, Ulrike, Kirilina, Evgeniya, Villringer, Arno, Fiebach, Jochen B., Mekle, Ralf

“…BOLD delay is an emerging, noninvasive method for assessing cerebral perfusion that does not require the use of intravenous contrast agents and is thus…”
Get full text

Neurotransmitter changes during interference task in anterior cingulate cortex: evidence from fMRI-guided functional MRS at 3 T by Kühn, Simone, Schubert, Florian, Mekle, Ralf, Wenger, Elisabeth, Ittermann, Bernd, Lindenberger, Ulman, Gallinat, Jürgen

“…Neural activity as indirectly observed in blood oxygenation level-dependent (BOLD) response is thought to reflect changes in neurotransmitter flux. In this…”
Get full text

Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke by Kufner, Anna, Khalil, Ahmed A, Galinovic, Ivana, Kellner, Elias, Mekle, Ralf, Rackoll, Torsten, Boehm-Sturm, Philipp, Fiebach, Jochen B, Flöel, Agnes, Ebinger, Martin, Endres, Matthias, Nave, Alexander H

“…MRI-based vessel size imaging (VSI) allows for in-vivo assessment of cerebral microvasculature and perfusion. This exploratory analysis of vessel size (VS) and…”
Get full text

Assessment of measurement precision in single‐voxel spectroscopy at 7 T: Toward minimal detectable changes of metabolite concentrations in the human brain in vivo by Riemann, Layla Tabea, Aigner, Christoph Stefan, Ellison, Stephen L. R., Brühl, Rüdiger, Mekle, Ralf, Schmitter, Sebastian, Speck, Oliver, Rose, Georg, Ittermann, Bernd, Fillmer, Ariane

“…Purpose To introduce a study design and statistical analysis framework to assess the repeatability, reproducibility, and minimal detectable changes (MDCs) of…”
Get full text