Search Results - "Mekky, Radwa Y."

MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer by Mekky, Radwa Y., Ragab, Mai F., Manie, Tamer, Attia, Abdelrahman A., Youness, Rana A.

“…Triple negative breast cancer (TNBC) is known as hot immunogenic tumor. Yet, it is one of the most aggressive BC subtypes. TNBC evolve several tactics to evade…”
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A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma by Assal, Reem A., Elemam, Noha M., Mekky, Radwa Y., Attia, Abdelrahman A., Soliman, Aya Hesham, Gomaa, Asmaa Ibrahim, Efthimiadou, Eleni K., Braoudaki, Maria, Fahmy, Sherif Ashraf, Youness, Rana A.

“…•PDL1, CD155, PD-1 and TIGIT are upregulated in liver tissues and PBMCs of HCC patients, respectively.•CCAT-1, H19, and MALAT-1 are significantly upregulated…”
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Evaluating Risk: Benefit Ratio of Fat-Soluble Vitamin Supplementation to SARS-CoV-2-Infected Autoimmune and Cancer Patients: Do Vitamin-Drug Interactions Exist? by Mekky, Radwa Y, Elemam, Noha M, Eltahtawy, Omar, Zeinelabdeen, Yousra, Youness, Rana A

“…COVID-19 is a recent pandemic that mandated the scientific society to provide effective evidence-based therapeutic approaches for the prevention and treatment…”
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A Snapshot of Photoresponsive Liposomes in Cancer Chemotherapy and Immunotherapy: Opportunities and Challenges by Youness, Rana A., Mohamed, Adham H., Efthimiadou, Eleni K., Mekky, Radwa Y., Braoudaki, Maria, Fahmy, Sherif Ashraf

“…To provide precise medical regimens, photonics technologies have been involved in the field of nanomedicine. Phototriggered liposomes have been cast as…”
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Vortioxetine ameliorates experimental autoimmune encephalomyelitis model of multiple sclerosis in mice via activation of PI3K/Akt/CREB/BDNF cascade and modulation of serotonergic pathway signaling by Shafiek, Marwa S., Mekky, Radwa Y., Nassar, Noha N., El-Yamany, Mohammed F., Rabie, Mostafa A.

“…Multiple sclerosis (MS) is a chronic condition characterized by immune cell infiltration and cytokine overproduction that led to myelin sheath inflammatory…”
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Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology by Elemam, Noha M, Mekky, Radwa Y, Rashid, Gowhar, Braoudaki, Maria, Youness, Rana A

“…The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics…”
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Epigenetic harnessing of HCV via modulating the lipid droplet-protein, TIP47, in HCV cell models by El-Ekiaby, Nada M., Mekky, Radwa Y., El Sobky, Shereen A., Elemam, Noha M., El-Sayed, Mohammed, Esmat, Gamal, Abdelaziz, Ahmed I.

“…•TIP47 is upregulated in liver biopsies of HCV infected patients.•miR-148a and miR-30a are downregulated in liver biopsies of HCV infected patients.•miR-148a…”
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miR‐148a and miR‐30a limit HCV‐dependent suppression of the lipid droplet protein, ADRP, in HCV infected cell models by El‐Ekiaby, Nada M., Mekky, Radwa Y., Riad, Sarah E., Elhelw, Dalia S., El‐Sayed, Mohammed, Esmat, Gamal, Abdelaziz, Ahmed I.

“…Hepatitis C Virus (HCV) promotes lipid droplet (LD) formation and perturbs the expression of the LD associated PAT proteins ADRP and TIP47, to promote its own…”
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Contradicting roles of miR-182 in both NK cells and their host target hepatocytes in HCV by El Sobky, Shereen A, El-Ekiaby, Nada M, Mekky, Radwa Y, Elemam, Noha M, Mohey Eldin, Mohammad A, El-sayed, Mohammed, Esmat, Gamal, Abdelaziz, Ahmed I

“…Highlights • miR-182 has dys-regulated expression in both NK cells and liver biopsies of HCV infected patients. • miR-182 and its inhibitor enhanced NK cell of…”
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Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients by Mekky, Radwa Y, Hamdi, Nabila, El-Akel, Wafaa, Esmat, Gamal, Abdelaziz, Ahmed I

“…Sex has been reported to influence the rates of viral clearance in hepatitis C virus (HCV)-infected patients. However, little is known regarding the influence…”
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Sex hormones and HCV: an unresolved mystery by Mekky, Radwa Y, Abdelaziz, Ahmed I

“…The biological differences between males and females advocate the ultimate need for gender-specific medicine. The variation in response to viral infection as…”
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