Search Results - "Mekenyan, O"

Evaluation of human pharmaceutical emissions and concentrations in Swedish river basins by Lindim, C., van Gils, J., Georgieva, D., Mekenyan, O., Cousins, I.T.

“…An emissions inventory for top consumed human pharmaceuticals in Sweden was done based on national consumption data, human metabolic rates and wastewater…”
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QSAR Toolbox - workflow and major functionalities by Dimitrov, S. D., Diderich, R., Sobanski, T., Pavlov, T. S., Chankov, G. V., Chapkanov, A. S., Karakolev, Y. H., Temelkov, S. G., Vasilev, R. A., Gerova, K. D., Kuseva, C. D., Todorova, N. D., Mehmed, A. M., Rasenberg, M., Mekenyan, O. G.

“…The OECD QSAR Toolbox is a software application intended to be used by governments, the chemical industry and other stakeholders in filling gaps in…”
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Model-predicted occurrence of multiple pharmaceuticals in Swedish surface waters and their flushing to the Baltic Sea by Lindim, C., van Gils, J., Cousins, I.T., Kühne, R., Georgieva, D., Kutsarova, S., Mekenyan, O.

“…An exposure assessment for multiple pharmaceuticals in Swedish surface waters was made using the STREAM-EU model. Results indicate that Metformin (27 ton/y),…”
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Hazard Evaluation Support System (HESS) for predicting repeated dose toxicity using toxicological categories by Sakuratani, Y., Zhang, H.Q., Nishikawa, S., Yamazaki, K., Yamada, T., Yamada, J., Gerova, K., Chankov, G., Mekenyan, O., Hayashi, M.

“…Repeated dose toxicity (RDT) is one of the most important hazard endpoints in the risk assessment of chemicals. However, due to the complexity of the endpoints…”
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Accounting for data variability, a key factor in in vivo/in vitro relationships: application to the skin sensitization potency (in vivo LLNA versus in vitro DPRA) example by Dimitrov, S., Detroyer, A., Piroird, C., Gomes, C., Eilstein, J., Pauloin, T., Kuseva, C., Ivanova, H., Popova, I., Karakolev, Y., Ringeissen, S., Mekenyan, O.

“…When searching for alternative methods to animal testing, confidently rescaling an in vitro result to the corresponding in vivo classification is still a…”
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Simulation of chemical metabolism for fate and hazard assessment. II CATALOGIC simulation of abiotic and microbial degradation by Dimitrov, S., Pavlov, T., Dimitrova, N., Georgieva, D., Nedelcheva, D., Kesova, A., Vasilev, R., Mekenyan, O.

“…The unprecedented pollution of the environment by xenobiotic compounds has provoked the need to understand the biodegradation potential of chemicals…”
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Identification of the Structural Requirements for Mutagencitiy, by Incorporating Molecular Flexibility and Metabolic Activation of Chemicals. II. General Ames Mutagenicity Model by Serafimova, R, Todorov, M, Pavlov, T, Kotov, S, Jacob, E, Aptula, A, Mekenyan, O

“…The tissue metabolic simulator (TIMES) modeling approach is a hybrid expert system that couples a metabolic simulator together with structure toxicity rules,…”
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Simulation of chemical metabolism for fate and hazard assessment. I. Approach for simulating metabolism by Dimitrov, S., Pavlov, T., Veith, G., Mekenyan, O.

“…Information regarding the metabolism of xenobiotic chemicals plays a central role in regulatory risk assessments. In regulatory programmes where metabolism…”
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Simulation of chemical metabolism for fate and hazard assessment. V. Mammalian hazard assessment by Mekenyan, O., Dimitrov, S., Pavlov, T., Dimitrova, G., Todorov, M., Petkov, P., Kotov, S.

“…Animals and humans are exposed to a wide array of xenobiotics and have developed complex enzymatic mechanisms to detoxify these chemicals. Detoxification…”
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Development of a biodegradation model for the prediction of metabolites in soil by Dimitrov, S., Nedelcheva, D., Dimitrova, N., Mekenyan, O.

“…The awareness of air, soil and water pollution has driven the search for better methods for the assessment of the environmental fate of industrial chemicals…”
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TIMES-SS - Recent refinements resulting from an industrial skin sensitisation consortium by Patlewicz, G., Kuseva, C., Mehmed, A., Popova, Y., Dimitrova, G., Ellis, G., Hunziker, R., Kern, P., Low, L., Ringeissen, S., Roberts, D.W., Mekenyan, O.

“…The TImes MEtabolism Simulator platform for predicting Skin Sensitisation (TIMES-SS) is a hybrid expert system, first developed at Bourgas University using…”
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CATALOGIC 301C model - validation and improvement by Dimitrova, N. H., Dermen, I. A., Todorova, N. D., Vasilev, K. G., Dimitrov, S. D., Mekenyan, O. G., Ikenaga, Y., Aoyagi, T., Zaitsu, Y., Hamaguchi, C.

“…In Europe, REACH legislation encourages the use of alternative in silico methods such as (Q)SAR models. According to the recent progress of Chemical Substances…”
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Base-line model for identifying the bioaccumulation potential of chemicals by Dimitrov, S., Dimitrova, N., Parkerton, T., Comber, M., Bonnell, M., Mekenyan, O.

“…The base-line modeling concept presented in this work is based on the assumption of a maximum bioconcentration factor (BCF ) with mitigating factors that…”
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The use of metabolising systems for in vitro testing of endocrine disruptors by Jacobs, M N, Janssens, W, Bernauer, U, Brandon, E, Coecke, S, Combes, R, Edwards, P, Freidig, A, Freyberger, A, Kolanczyk, R, Mc Ardle, C, Mekenyan, O, Schmieder, P, Schrader, T, Takeyoshi, M, van der Burg, B

“…Legislation and prospective legislative proposals in for instance the USA, Europe, and Japan require, or may require that chemicals are tested for their…”
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Simulation of chemical metabolism for fate and hazard assessment. III. New developments of the bioconcentration factor base-line model by Dimitrov, S., Dimitrova, N., Georgieva, D., Vasilev, K., Hatfield, T., Straka, J., Mekenyan, O.

“…The new development of the bioconcentration factor (BCF) base-line model of Dimitrov et al. [SAR QSAR Environ. Res. 6 (2005), pp. 531-554] is presented. The…”
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Predicting bioconcentration factors of highly hydrophobic chemicals. Effects of molecular size by Dimitrov, S. D., Dimitrova, N. C., Walker, J. D., Veith, G. D., Mekenyan, O. G.

“…The bioconcentration factor (BCF) is a parameter that describes the ability of chemicals to concentrate in aquatic organisms. Traditionally, it is modeled by…”
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Simulation of chemical metabolism for fate and hazard assessment. IV. Computer-based derivation of metabolic simulators from documented metabolism maps by Karabunarliev, S., Dimitrov, S., Pavlov, T., Nedelcheva, D., Mekenyan, O.

“…Computer simulation of xenobiotic metabolism and degradation is usually performed proceeding from a set of expert-developed rules modelling the actual…”
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Androgen receptor binding affinity: a QSAR evaluation by Todorov, M., Mombelli, E., Aït-Aïssa, S., Mekenyan, O.

“…The multiparameter formulation of the COmmon REactivity PAttern (COREPA) approach has been used to describe the structural requirements for eliciting rat…”
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Probabilistic assessment of biodegradability based on metabolic pathways: CATABOL System by Jaworska, J., Dimitrov, S., Nikolova, N., Mekenyan, O.

“…A novel mechanistic modeling approach has been developed that assesses chemical biodegradability in a quantitative manner. It is an expert system predicting…”
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Elimination kinetic model for organic chemicals in earthworms by Dimitrova, N., Dimitrov, S., Georgieva, D., Van Gestel, C.A.M., Hankard, P., Spurgeon, D., Li, H., Mekenyan, O.

“…Mechanistic understanding of bioaccumulation in different organisms and environments should take into account the influence of organism and chemical depending…”
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