Search Results - "Mekel, Marlene"

Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein by McConnell, Patrick, Mekel, Marlene, Kozlov, Alexander G, Mooren, Olivia L, Lohman, Timothy M, Cooper, John A

“…The heterodimeric actin capping protein (CP) is regulated by a set of proteins that contain CP-interacting (CPI) motifs. Outside of the CPI motif, the…”
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Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange by Johnson, Britney, McConnell, Patrick, Kozlov, Alex G., Mekel, Marlene, Lohman, Timothy M., Gross, Michael L., Amarasinghe, Gaya K., Cooper, John A.

“…Actin assembly is important for cell motility. The ability of actin subunits to join or leave filaments via the barbed end is critical to actin dynamics…”
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Isolation and Expression of a Malassezia globosa Lipase Gene, LIP1 by DeAngelis, Yvonne M., Saunders, Charles W., Johnstone, Kevin R., Reeder, Nancy L., Coleman, Christal G., Kaczvinsky, Joseph R., Gale, Celeste, Walter, Richard, Mekel, Marlene, Lacey, Martin P., Keough, Thomas W., Fieno, Angela, Grant, Raymond A., Begley, Bill, Sun, Yiping, Fuentes, Gary, Scott Youngquist, R., Xu, Jun, Dawson, Thomas L.

“…Dandruff and seborrheic dermatitis (D/SD) are common hyperproliferative scalp disorders with a similar etiology. Both result, in part, from metabolic activity…”
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The crystal structures of the psychrophilic subtilisin S41 and the mesophilic subtilisin Sph reveal the same calcium-loaded state by Almog, Orna, González, Ana, Godin, Noa, de Leeuw, Marina, Mekel, Marlene J., Klein, Daniela, Braun, Sergei, Shoham, Gil, Walter, Richard L.

“…We determine and compare the crystal structure of two proteases belonging to the subtilisin superfamily: S41, a cold‐adapted serine protease produced by…”
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The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck) by Sabat, Mark, VanRens, John C., Laufersweiler, Matthew J., Brugel, Todd A., Maier, Jennifer, Golebiowski, Adam, De, Biswanath, Easwaran, Vijayasurian, Hsieh, Lily C., Walter, Richard L., Mekel, Marlene J., Evdokimov, Artem, Janusz, Michael J.

“…This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent…”
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Development of Orally Bioavailable Bicyclic Pyrazolones as Inhibitors of Tumor Necrosis Factor-α Production by Clark, Michael P, Laughlin, Steven K, Laufersweiler, Matthew J, Bookland, Roger G, Brugel, Todd A, Golebiowski, Adam, Sabat, Mark P, Townes, Jennifer A, VanRens, John C, Djung, Jane F, Natchus, Michael G, De, Biswanath, Hsieh, Lily C, Xu, Susan C, Walter, Rick L, Mekel, Marlene J, Heitmeyer, Sandra A, Brown, Kimberly K, Juergens, Karen, Taiwo, Yetunde O, Janusz, Michael J

“…2-Aryl-3-pyrimidinyl based tumor necrosis factor-α (TNF-α) inhibitors, which contain a novel bicyclic pyrazolone core, are described. Many showed low-nanomolar…”
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The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production by Laughlin, Steven K., Clark, Michael P., Djung, Jane F., Golebiowski, Adam, Brugel, Todd A., Sabat, Mark, Bookland, Roger G., Laufersweiler, Matthew J., VanRens, John C., Townes, Jennifer A., De, Biswanath, Hsieh, Lily C., Xu, Susan C., Walter, Richard L., Mekel, Marlene J., Janusz, Michael J.

“…[Display omitted] 4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-α) inhibitors, which contain a novel isoxazolone…”
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Development of N-2,4-pyrimidine-N-phenyl-N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1 by Brugel, Todd A., Maier, Jennifer A., Clark, Michael P., Sabat, Mark, Golebiowski, Adam, Bookland, Roger G., Laufersweiler, Matthew J., Laughlin, Steven K., VanRens, John C., De, Biswanath, Hsieh, Lily C., Mekel, Marlene J., Janusz, Michael J.

“…A new class of tumor necrosis factor alpha (TNF-α) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N′-phenyl urea scaffold is described. A new class…”
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The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production by Sabat, Mark, VanRens, John C., Clark, Michael P., Brugel, Todd A., Maier, Jennifer, Bookland, Roger G., Laufersweiler, Matthew J., Laughlin, Steven K., Golebiowski, Adam, De, Biswanath, Hsieh, Lily C., Walter, Richard L., Mekel, Marlene J., Janusz, Michael J.

“…A series of C-2, C-8, and N-9 trisubstituted purine based inhibitors of TNF-α production are described. The most potent analogs showed low nanomolar activity…”
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The development of monocyclic pyrazolone based cytokine synthesis inhibitors by Golebiowski, Adam, Townes, Jennifer A., Laufersweiler, Matthew J., Brugel, Todd A., Clark, Michael P., Clark, Cynthia M., Djung, Jane F., Laughlin, Steven K., Sabat, Mark P., Bookland, Roger G., VanRens, John C., De, Biswanath, Hsieh, Lily C., Janusz, Michael J., Walter, Richard L., Webster, Mark E., Mekel, Marlene J.

“…[Display omitted] 4-Aryl-5-pyrimidyl based cytokine synthesis inhibitors that contain a novel monocyclic, pyrazolone heterocyclic core are described. Many of…”
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The development of novel inhibitors of tumor necrosis factor-α (TNF-α) production based on substituted [5,5]-bicyclic pyrazolones by Laufersweiler, Matthew J, Brugel, Todd A, Clark, Michael P, Golebiowski, Adam, Bookland, Roger G, Laughlin, Steven K, Sabat, Mark P, Townes, Jennifer A, VanRens, John C, De, Biswanath, Hsieh, Lily C, Heitmeyer, Sandra A, Juergens, Karen, Brown, Kimberly K, Mekel, Marlene J, Walter, Richard L, Janusz, Michael J

“…Graphic Novel substituted [5,5]-bicyclic pyrzazolones are presented as inhibitors of tumor necrosis factor-α (TNF-α) production. Many of these compounds show…”
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CPI-motif Regulation of Biochemical Functions of Actin Capping Protein by McConnell, Patrick, Mekel, Marlene, Kozlov, Alexander G., Mooren, Olivia L., Lohman, Timothy M., Cooper, John A.

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CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish by Stark, Benjamin C., Gao, Yuanyuan, Sepich, Diane S., Belk, Lakyn, Culver, Matthew A., Hu, Bo, Mekel, Marlene, Ferris, Wyndham, Shin, Jimann, Solnica-Krezel, Lilianna, Lin, Fang, Cooper, John A.

“…Cell migration is important during early animal embryogenesis. Cell migration and cell shape are controlled by actin assembly and dynamics, which depend on…”
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Method for the Preparation of Gram Quantities of Highly Purified Bowman Birk Inhibitor from Glycine max by Tulk, Barry Michael, Mekel, Marlene, Wu, Jennifer, Schasteen, Charles

“…Abstract only Bowman Birk Inhibitor (BBI) is a trypsin/chymotrypsin inhibitor originally prepared from soybean extract that has been implicated as a potential…”
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Design and synthesis of a series of novel pyrazolopyridines as HIF 1-α prolyl hydroxylase inhibitors by Warshakoon, Namal C., Wu, Shengde, Boyer, Angelique, Kawamoto, Richard, Renock, Sean, Xu, Kevin, Pokross, Matthew, Evdokimov, Artem G., Zhou, Songtao, Winter, Carol, Walter, Richard, Mekel, Marlene

“…Recently resolved X-ray crystal structure of HIF-1α prolyl hydroxylase was used to design and develop a novel series of pyrazolopyridines as potent HIF-1α…”
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A novel series of imidazo[1,2- a]pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors by Warshakoon, Namal C., Wu, Shengde, Boyer, Angelique, Kawamoto, Richard, Sheville, Justin, Renock, Sean, Xu, Kevin, Pokross, Matthew, Evdokimov, Artem G., Walter, Richard, Mekel, Marlene

“…Utilizing modeling information from a recently resolved structure of human HIF-1α prolyl hydroxylase (EGLN1) and structure-based design, a novel series of…”
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Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1α prolyl hydroxylase inhibitors by Warshakoon, Namal C., Wu, Shengde, Boyer, Angelique, Kawamoto, Richard, Sheville, Justin, Renock, Sean, Xu, Kevin, Pokross, Matthew, Zhou, Songtao, Winter, Carol, Walter, Richard, Mekel, Marlene, Evdokimov, Artem G.

“…A new series of potent 8-hydroxyquinolines was designed based on the newly resolved X-ray crystal structure of EGLN-1. Both alkyl and aryl…”
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Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis by Hopkins, Corey R., O’Neil, Steven V., Laufersweiler, Michael C., Wang, Yili, Pokross, Matthew, Mekel, Marlene, Evdokimov, Artem, Walter, Richard, Kontoyianni, Maria, Petrey, Maria E., Sabatakos, Georgios, Roesgen, Jeff T., Richardson, Eloise, Demuth, Thomas P.

“…The synthesis and structure–activity relationships of a novel series of N-sulfonyl-2-indole carboxamides that bind to peroxisome proliferator-activated…”
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Design and synthesis of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors by Warshakoon, Namal C., Wu, Shengde, Boyer, Angelique, Kawamoto, Richard, Sheville, Justin, Bhatt, Ritu Tiku, Renock, Sean, Xu, Kevin, Pokross, Matthew, Zhou, Songtao, Walter, Richard, Mekel, Marlene, Evdokimov, Artem G., East, Stephen

“…Structure-guided de novo drug design led to the identification of a novel series of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors…”
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The development of novel inhibitors of tumor necrosis factor-alpha production based on substituted [5,5]-bicyclic pyrozolones by Laufersweiler, Matthew, Brugel, Todd, Clark, Michael, Golebiowski, Adam, Bookland, Roger, Laughlin, Steven, Sabat, Mark, Townes, Jennifer, VanRens, John, De, Biswanath, Hsieh, Lily, Heitmeyer, Sandra, Juergens, Karen, Brown, Kimberly, Mekel, Marlene, Walter, Richard, Janusz, Michael

“…Novel substituted [5,5]-bicyclic pyrzazolones are presented as inhibitors of tumor necrosis factor-{alpha} (TNF-{alpha}) production. Many of these compounds…”
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