Search Results - "Mekala, Divya"

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity by Washburn, Nathaniel, Schwab, Inessa, Ortiz, Daniel, Bhatnagar, Naveen, Lansing, Jonathan C., Medeiros, Amy, Tyler, Steven, Mekala, Divya, Cochran, Edward, Sarvaiya, Hetal, Garofalo, Kevin, Meccariello, Robin, Meador, James W., Rutitzky, Laura, Schultes, Birgit C., Ling, Leona, Avery, William, Nimmerjahn, Falk, Manning, Anthony M., Kaundinya, Ganesh V., Bosques, Carlos J.

“…Despite the beneficial therapeutic effects of intravenous immunoglobulin (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain…”
Get full text

Novel BCL-2 Inhibitor Lisaftoclax in Relapsed or Refractory Chronic Lymphocytic Leukemia and Other Hematologic Malignancies: First-in-Human Open-Label Trial by Ailawadhi, Sikander, Chen, Zi, Huang, Bo, Paulus, Aneel, Collins, Mary C, Fu, Lei Tommy, Li, Mingyu, Ahmad, Mohammad, Men, Lichuang, Wang, Hengbang, Davids, Matthew S, Liang, Eric, Mekala, Divya J, He, Zhicong, Lasica, Masa, Yannakou, Costas K, Parrondo, Ricardo, Glass, Laura, Yang, Dajun, Chanan-Khan, Asher, Zhai, Yifan

“…This global phase I trial investigated the safety, efficacy, pharmacokinetics, and pharmacodynamics of lisaftoclax (APG-2575), a novel, orally active, potent…”
Get full text

Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes by Mekala, Divya J., Geiger, Terrence L.

“…We developed an approach that increases CD4+CD25+ regulatory T-cell potency by antigen-specifically redirecting them against pathologic T lymphocytes. The…”
Get full text

Mac-1 Signaling via Src-Family and Syk Kinases Results in Elastase-Dependent Thrombohemorrhagic Vasculopathy by Hirahashi, Junichi, Mekala, Divya, Van Ziffle, Jessica, Xiao, Ling, Saffaripour, Simin, Wagner, Denisa D., Shapiro, Steven D., Lowell, Clifford, Mayadas, Tanya N.

“…CD18 integrins promote neutrophil recruitment, and their engagement activates tyrosine kinases, leading to neutrophil activation. However, the significance of…”
Get full text

IL-10-Dependent Infectious Tolerance after the Treatment of Experimental Allergic Encephalomyelitis with Redirected CD4+CD25+T Lymphocytes by Mekala, Divya J., Alli, Rajshekhar S., Geiger, Terrence L., Flavell, Richard A.

“…How small numbers of CD4+CD25+regulatory T cells suppress autoimmune responses in vivo is unclear. In this report we analyze the immunomodulatory activity of…”
Get full text

Regulation of ZAP-70 Activation and TCR Signaling by Two Related Proteins, Sts-1 and Sts-2 by Carpino, Nick, Turner, Steve, Mekala, Divya, Takahashi, Yutaka, Zang, Heesuk, Geiger, Terrence L., Doherty, Peter, Ihle, James N.

“…T cells play a central role in the recognition and elimination of foreign pathogens. Signals through the T cell receptor (TCR) control the extent and duration…”
Get full text

Uncoupling of IL-2 signaling from cell cycle progression in naive CD4+ T cells by regulatory CD4+CD25+ T lymphocytes by Duthoit, Christine T, Mekala, Divya J, Alli, Rajshekkhar S, Geiger, Terrence L

“…Prior reports have shown that CD4(+)CD25(+) regulatory T cells suppress naive T cell responses by inhibiting IL-2 production. In this report, using an…”
Get full text

IL-10-Dependent Suppression of Experimental Allergic Encephalomyelitis by Th2-Differentiated, Anti-TCR Redirected T Lymphocytes by Mekala, Divya J, Alli, Rajshekhar S, Geiger, Terrence L

“…We previously showed that transgenically expressed chimeric Ag-MHC-zeta receptors can Ag-specifically redirect T cells against other T cells. When the…”
Get full text

Functional Segregation of the TCR and Antigen-MHC Complexes on the Surface of CTL by Mekala, Divya J, Geiger, Terrence L

“…As CTL adhere to and lyze their targets, they extract cognate Ag-MHC and represent this on their own cell surface. Whether such self-presented cognate Ag…”
Get full text

Development of the first reference antibody panel for qualification and validation of cytokine release assay platforms – Report of an international collaborative study by Vessillier, Sandrine, Fort, Madeline, O'Donnell, Lynn, Hinton, Heather, Nadwodny, Kimberly, Piccotti, Joseph, Rigsby, Peter, Staflin, Karin, Stebbings, Richard, Mekala, Divya, Willingham, Aarron, Wolf, Babette

“…•Cytokine release syndrome is a concern for novel antibody therapeutics.•In vitro cytokine release assays are key for hazard identification.•Positive and…”
Get full text

M281: A Therapeutic Anti-FcRn Blocking Antibody for Rapid Clearance of IgG and IgG Autoantibodies in Immune Cytopenias and Other Auto/Allo-Immune Disease by Ling, Leona E, Roy, Sucharita, Daly, Thomas, Cochran, Edward, Tyler, Steven, Markowitz, Lynn, Bulik, Dorota, Choudhury, Amit, Meador, James, Parge, Viraj, Mekala, Divya, Sipsey, Sandra, Gurnani, Srishti, Duffner, Jay, Lee, Stan, Washburn, Nathaniel, Meccariello, Robin, Schaeck, John, Wang, Jing, Schultes, Birgit, Hillson, Jan L., Avery, William, Kaundinya, Ganesh V., Manning, Anthony M.

“…Introduction IgG antibodies are the primary pathogenic agent in a number of auto- or allo-immune diseases. Efficacious therapies which decrease systemic levels…”
Get full text

Requirement for Vav Proteins in Post-Recruitment Neutrophil Cytotoxicity in IgG but Not Complement C3-Dependent Injury by Utomo, Ahmad, Hirahashi, Junichi, Mekala, Divya, Asano, Kenichi, Glogauer, Michael, Cullere, Xavier, Mayadas, Tanya N

“…The signals linking neutrophil opsonic receptors, FcgammaRs and complement receptor 3 (Mac-1) to cellular cytotoxic responses are poorly understood…”
Get full text

Regulation of human neutrophil Fc[gamma] receptor IIa by C5a receptor promotes inflammatory arthritis in mice by Tsuboi, Naotake, Ernandez, Thomas, Li, Xun, Nishi, Hiroshi, Cullere, Xavier, Mekala, Divya, Hazen, Melissa, Kohl, Jörg, Lee, David M, Mayadas, Tanya N

“…Objective Rheumatoid arthritis culminates in joint destruction that, in mouse models of disease, is supported by innate immune molecules, including Fc[gamma]…”
Get full text

IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4 super(+)CD25 super(+) T lymphocytes by Mekala, Divya J, Alli, Rajshekhar S, Geiger, Terrence L

“…How small numbers of CD4 super(+)CD25 super(+) regulatory T cells suppress autoimmune responses in vivo is unclear. In this report we analyze the…”
Get full text

Uncoupling of IL-2 Signaling from Cell Cycle Progression in Naive CD4 super(+) T Cells by Regulatory CD4 super(+)CD25 super(+) T Lymphocytes by Duthoit, Christine T, Mekala, Divya J, Alli, Rajshekkhar S, Geiger, Terrence L

“…Prior reports have shown that CD4 super(+)CD25 super(+) regulatory T cells suppress naive T cell responses by inhibiting IL-2 production. In this report, using…”
Get full text

Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice by Tsuboi, Naotake, Ernandez, Thomas, Li, Xun, Nishi, Hiroshi, Cullere, Xavier, Mekala, Divya, Hazen, Melissa, Köhl, Jörg, Lee, David M., Mayadas, Tanya N.

“…Objective Rheumatoid arthritis culminates in joint destruction that, in mouse models of disease, is supported by innate immune molecules, including Fcγ…”
Get full text

Human neutrophil FcγRIIA regulation by C5aR promotes inflammatory arthritis in mice by Tsuboi, Naotake, Ernandez, Thomas, Li, Xun, Nishi, Hiroshi, Cullere, Xavier, Mekala, Divya, Hazen, Melissa, Köhl, Jörg, Lee, David M., Mayadas, Tanya N.

Get full text