Search Results - "Mekala, Armugam"

Multiple sclerosis disease activity, a multi-biomarker score of disease activity and response to treatment in multiple sclerosis by Tatomir, Alexandru, Anselmo, Freidrich, Boodhoo, Dallas, Chen, Hegang, Mekala, Armugam P, Nguyen, Vinh, Cuevas, Jacob, Rus, Violeta, Rus, Horea

“…Regular assessment of disease activity in relapsing-remitting multiple sclerosis (RRMS) is required to optimize clinical outcomes. Biomarkers can be a valuable…”
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JNK and phosphorylated Bcl-2 predict multiple sclerosis clinical activity and glatiramer acetate therapeutic response by Anselmo, Freidrich, Tatomir, Alexandru, Boodhoo, Dallas, Mekala, Armugam P., Nguyen, Vinh, Rus, Violeta, Rus, Horea

“…In this study, we investigated the role of JNK and phospho-Bcl-2 as possible biomarkers of multiple sclerosis (MS) relapse and of glatiramer acetate (GA)…”
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The role of complement activation in atherogenesis: the first 40 years by Vlaicu, Sonia I., Tatomir, Alexandru, Rus, Violeta, Mekala, Armugam P., Mircea, Petru A., Niculescu, Florin, Rus, Horea

“…The pathogenesis of atherosclerotic inflammation is a multi-step process defined by the interweaving of excess modified lipid particles, monocyte-macrophages…”
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Role of SIRT1 in autoimmune demyelination and neurodegeneration by Martin, Alvaro, Tegla, Cosmin A., Cudrici, Cornelia D., Kruszewski, Adam M., Azimzadeh, Philippe, Boodhoo, Dallas, Mekala, Armugam P., Rus, Violeta, Rus, Horea

“…Multiple sclerosis (MS) is a demyelinating disease characterized by chronic inflammation of the central nervous system, in which many factors can act together…”
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RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis by Rus, Violeta, Nguyen, Vinh, Tatomir, Alexandru, Lees, Jason R, Mekala, Armugam P, Boodhoo, Dallas, Tegla, Cosmin A, Luzina, Irina G, Antony, Paul A, Cudrici, Cornelia D, Badea, Tudor C, Rus, Horea G

“…Th17 cells play a critical role in autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Response…”
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A Flare-up of Systemic Lupus Erythematosus with Unusual Enteric Predominance by Ronen, Joshua A, Mekala, Armugam, Wiechmann, Catherine, Mungara, Sai

“…Enteritis associated with systemic lupus erythematosus (SLE) is a rare and unusual manifestation of the gastrointestinal (GI) consequences of SLE itself…”
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RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis by Tatomir, Alexandru, Beltrand, Austin, Nguyen, Vinh, Boodhoo, Dallas, Mekala, Armugam, Cudrici, Cornelia, Badea, Tudor C, Muresanu, Dafin F, Rus, Violeta, Rus, Horea

“…Astrocytes are increasingly recognized as critical contributors to multiple sclerosis pathogenesis. We have previously shown that lack of Response Gene to…”
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Amantadine-Induced Cardiac Arrest in a Patient With COVID-19 by Bakhati, Bibek, Sibi, Victoria M, Mekala, Armugam P, Ronen, Joshua A, Mungara, Sai S

“…Amantadine, which is known for its antiviral activity, is presently used as therapy for Parkinson's disease. Adverse effects, such as cardiac arrhythmias, have…”
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RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis by Tatomir, Alexandru, Tegla, Cosmin A., Martin, Alvaro, Boodhoo, Dallas, Nguyen, Vinh, Sugarman, Adam J., Mekala, Armugam, Anselmo, Freidrich, Talpos-Caia, Anamaria, Cudrici, Cornelia, Badea, Tudor C., Rus, Violeta, Rus, Horea

“…Extracellular matrix (ECM) deposition in active demyelinating multiple sclerosis (MS) lesions may impede axonal regeneration and can modify immune reactions…”
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RGC-32 is expressed in the human atherosclerotic arterial wall: Role in C5b-9-induced cell proliferation and migration by Vlaicu, Sonia I., Tatomir, Alexandru, Boodhoo, Dallas, Ito, Takahiro, Fosbrink, Matthew, Cudrici, Cornelia, Mekala, Armugam P., Ciriello, Jonathan, Crişan, Doiniţa, Boţan, Emil, Rus, Violeta, Rus, Horea

“…The complement system is an important player in the development of atherosclerosis. Previously reported as a cell cycle regulator, RGC-32 is an essential…”
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RGC-32 is a novel regulator of the T-lymphocyte cell cycle by Tegla, Cosmin A., Cudrici, Cornelia D., Nguyen, Vinh, Danoff, Jacob, Kruszewski, Adam M., Boodhoo, Dallas, Mekala, Armugam P., Vlaicu, Sonia I., Chen, Ching, Rus, Violeta, Badea, Tudor C., Rus, Horea

“…We have previously shown that RGC-32 is involved in cell cycle regulation in vitro. To define the in vivo role of RGC-32, we generated RGC-32 knockout mice…”
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What Is Uncommon Can Be Critical: A Case of Quinolone-Induced Acute Liver Failure by Bakhati, Bibek, Sibi, Victoria M, Mekala, Armugam P, Ronen, Joshua A, Mungara, Sai

“…Many drugs are known to potentially cause liver injury; however, only a few reports investigate the association between levofloxacin and acute liver failure…”
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Heroin Relapse "Strikes a Nerve": A Rare Case of Drug-Induced Acute Myelopathy by Sidhu, Mandeep K, Mekala, Armugam P, Ronen, Joshua A, Hamdan, Ahmad, Mungara, Sai S

“…Opioid addiction is a major public health problem. Through a commitment to individualized treatment plans meant to help patients meet personal goals,…”
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RGC-32 promotes Th17 cell differentiation and enhances experimental autoimmune encephalomyelitis by Rus, Violeta, Nguyen, Vinh, Tatomir, Alexandru, Boodhoo, Dallas, Mekala, Armugam P, Cudrici, Cornelia, Badea, Tudor C, Rus, Horea

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RGC-32 enhances experimental autoimmune encephalomyelitis by promoting Il-17 and GM-CSF production by Rus, Violeta, Nguyen, Vinh, Tatomir, Alexandru, Mekala, Armugam Prasad, Boodhoo, Dallas, Rus, Horea G

“…Response Gene to Complement (RGC)-32 is an intracytoplasmatic protein expressed in a variety of cells in response to sublytic complement activation, TGF-β and…”
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Response Gene to Complement-32 promotes Th17 cell differentiation through TGF-β dependent and independent mechanisms by Rus, Violeta, Nguyen, Vinh, Tatomir, Alexandru, Mekala, Armugam Prasad, Rus, Horea G

“…Response Gene to Complement (RGC)-32 is an intracytoplasmatic protein expressed in a variety of cells in response to sublytic complement activation, TGF-β and…”
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RGC-32 enhances suboptimal CD8 cytotoxic T cell effector function in acute graft versus host disease and promotes lupus-like disease in chronic graft versus host disease (THER2P.965) by Rus, Violeta, Nguyen, Vinh, Badea, Tudor, Cudrici, Cornelia, Tegla, Cosmin, Mekala, Armugam, Rus, Horea

“…Response Gene to Complement (RGC)-32 is an intracytoplasmatic protein expressed in a variety of cells in response to sublytic complement activation, TGFb and…”
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RGC-32 regulates TGF-β extracellular matrix production in multiple sclerosis by Tatomir, Alexandru, Tegla, Cosmin A, Cudrici, Cornelia D, Boodhoo, Dallas, Martin, Alvaro, Mekala, Armugam, Rus, Violeta, Badea, Tudor C, Rus, Horea

“…Extracellular matrix (ECM) deposition in demyelinating multiple sclerosis (MS) lesions may impede axonal regeneration and modify immune responses. RGC-32 plays…”
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Amantadine-Induced Cardiac Arrest in a Patient With COVID-19 by Bakhati, Bibek, Sibi, Victoria M, Mekala, Armugam P, Ronen, Joshua A, Mungara, Sai S

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A Flare-up of Systemic Lupus Erythematosus with Unusual Enteric Predominance by Ronen, Joshua A, Mekala, Armugam, Wiechmann, Catherine, Mungara, Sai

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