Search Results - "Mejía Oneto, José Manuel"

SQ3370 Activates Cytotoxic Drug via Click Chemistry at Tumor and Elicits Sustained Responses in Injected and Non‐Injected Lesions by Srinivasan, Sangeetha, Yee, Nathan Alexander, Wu, Kui, Zakharian, Michael, Mahmoodi, Amir, Royzen, Maksim, Mejía Oneto, José Manuel

“…While systemic immuno‐oncology therapies have shown remarkable success, only a limited subset of patients benefit from them. The Click Activated Protodrugs…”
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Effect of local activation via SQ3370 on the safety of chemotherapy with concomitant anti-tumor immune response by Srinivasan, Sangeetha, Yee, Nathan A., Mahmoodi, Amir, Zakharian, Michael, Mejia Oneto, Jose Manuel

“…Abstract only e15525 Background: With systemic chemotherapy, only 1-2% of the dose given reaches a local tumor, while the remaining leads to off-target…”
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Interim phase 1 results for SQ3370 in advanced solid tumors by Chawla, Sant P., Batty, Kathleen, Aleckovic, Masa, Bhadri, Vivek, Bui, Nam, Guminski, Alexander David, Mejia Oneto, Jose Manuel, Srinivasan, Sangeetha, Strauss, James Fredric, Subbiah, Vivek, Weiss, Mia C., Wilson, Rosalind, Yee, Nathan A., Zakharian, Michael, Kwatra, Vineet

“…3085 Background: SQ3370, a novel therapy, utilizes Shasqi’s proprietary Click Activated Protodrugs Against Cancer (CAPAC) platform where mutually-reactive…”
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Local drug activation technology to make cytotoxics safer for localized solid tumors by Srinivasan, Sangeetha, Yee, Nathan, Dela Cruz, Filemon, Kung, Andrew, Gaviria, Ervin, Miller, Ethan, Royzen, Maksim, Mejia Oneto, Jose Manuel

“…Abstract only…”
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The use of push -pull dipoles for the construction of indole alkaloids: A total synthesis of aspidophytine by Mejia-Oneto, Jose Manuel

“…Push-pull dipoles generated from the Rh(II)-catalyzed reaction of diazo imides undergo successful intramolecular 1,3-dipolar cycloaddition across both alkenyl…”
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The use of push-pull dipoles for the construction of indole alkaloids: A total synthesis of aspidophytine by Mejia-Oneto, Jose Manuel

“…Push-pull dipoles generated from the Rh(II)-catalyzed reaction of diazo imides undergo successful intramolecular 1,3-dipolar cycloaddition across both alkenyl…”
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