Search Results - "Meisner‐Kober, Nicole"

The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing by Stalder, Lukas, Heusermann, Wolf, Sokol, Lena, Trojer, Dominic, Wirz, Joel, Hean, Justin, Fritzsche, Anja, Aeschimann, Florian, Pfanzagl, Vera, Basselet, Pascal, Weiler, Jan, Hintersteiner, Martin, Morrissey, David V, Meisner-Kober, Nicole C

“…Despite progress in mechanistic understanding of the RNA interference (RNAi) pathways, the subcellular sites of RNA silencing remain under debate. Here we show…”
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Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties by Nordin, Joel Z., M.D, Lee, Yi, BSc, Vader, Pieter, PhD, Mäger, Imre, PhD, Johansson, Henrik J., PhD, Heusermann, Wolf, PhD, Wiklander, Oscar P.B., M.D, Hällbrink, Mattias, PhD, Seow, Yiqi, DPhil, Bultema, Jarred J., PhD, Gilthorpe, Jonathan, PhD, Davies, Tim, MSc, Fairchild, Paul J., PhD, Gabrielsson, Susanne, PhD, Meisner-Kober, Nicole C., PhD, Lehtiö, Janne, PhD, Smith, C.I. Edvard, M.D., PhD, Wood, Matthew J.A., M.D., DPhil, Andaloussi, Samir EL, PhD

“…Abstract Extracellular vesicles (EVs) are natural nanoparticles that mediate intercellular transfer of RNA and proteins and are of great medical interest;…”
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Structural basis of siRNA recognition by TRBP double‐stranded RNA binding domains by Masliah, Gregoire, Maris, Christophe, König, Sebastian LB, Yulikov, Maxim, Aeschimann, Florian, Malinowska, Anna L, Mabille, Julie, Weiler, Jan, Holla, Andrea, Hunziker, Juerg, Meisner‐Kober, Nicole, Schuler, Benjamin, Jeschke, Gunnar, Allain, Frederic H‐T

“…The accurate cleavage of pre‐micro(mi)RNAs by Dicer and mi/siRNA guide strand selection are important steps in forming the RNA‐induced silencing complex…”
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Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER by Heusermann, Wolf, Hean, Justin, Trojer, Dominic, Steib, Emmanuelle, von Bueren, Stefan, Graff-Meyer, Alexandra, Genoud, Christel, Martin, Katrin, Pizzato, Nicolas, Voshol, Johannes, Morrissey, David V, Andaloussi, Samir E L, Wood, Matthew J, Meisner-Kober, Nicole C

“…Exosomes are nanovesicles released by virtually all cells, which act as intercellular messengers by transfer of protein, lipid, and RNA cargo. Their…”
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Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM by Ripin, Nina, Boudet, Julien, Duszczyk, Malgorzata M., Hinniger, Alexandra, Faller, Michael, Krepl, Miroslav, Gadi, Abhilash, Schneider, Robert J., Šponer, Jiří, Meisner-Kober, Nicole C., Allain, Frédéric H.-T.

“…Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–rich elements (AU-rich elements; AREs). These are a major class of…”
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EVAnalyzer: High content imaging for rigorous characterisation of single extracellular vesicles using standard laboratory equipment and a new open‐source ImageJ/Fiji plugin by Schürz, Melanie, Danmayr, Joachim, Jaritsch, Maria, Klinglmayr, Eva, Benirschke, Heloisa Melo, Matea, Cristian‐Tudor, Zimmerebner, Patrick, Rauter, Jakob, Wolf, Martin, Gomes, Fausto Gueths, Kratochvil, Zdenek, Heger, Zbynek, Miller, Andrew, Heuser, Thomas, Stanojlovic, Vesna, Kiefer, Jana, Plank, Tanja, Johnson, Litty, Himly, Martin, Blöchl, Constantin, Huber, Christian G., Hintersteiner, Martin, Meisner‐Kober, Nicole

“…Extracellular vesicle (EV) research increasingly demands for quantitative characterisation at the single vesicle level to address heterogeneity and complexity…”
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Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging by Corso, Giulia, Heusermann, Wolf, Trojer, Dominic, Görgens, André, Steib, Emmanuelle, Voshol, Johannes, Graff, Alexandra, Genoud, Christel, Lee, Yi, Hean, Justin, Nordin, Joel Z., Wiklander, Oscar P.B., El Andaloussi, Samir, Meisner-Kober, Nicole

“…Extracellular vesicles (EV) convey biological information by transmitting macromolecules between cells and tissues and are of great promise as pharmaceutical…”
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The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2 by Young, Lisa E, Moore, Ashleigh E, Sokol, Lena, Meisner-Kober, Nicole, Dixon, Dan A

“…Commonly observed in colorectal cancer is the elevated expression of the prostaglandin (PG) synthase COX-2. In normal intestinal epithelium, the COX-2 mRNA is…”
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Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis? by Jarzab, Miroslaw, Posselt, Gernot, Meisner-Kober, Nicole, Wessler, Silja

“…Persistent infections with the human pathogen Helicobacter pylori (H. pylori) have been closely associated with the induction and progression of a wide range…”
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HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis by Lang, Michaela, Berry, David, Passecker, Katharina, Mesteri, Ildiko, Bhuju, Sabin, Ebner, Florian, Sedlyarov, Vitaly, Evstatiev, Rayko, Dammann, Kyle, Loy, Alexander, Kuzyk, Orest, Kovarik, Pavel, Khare, Vineeta, Beibel, Martin, Roma, Guglielmo, Meisner-Kober, Nicole, Gasche, Christoph

“…HuR is an RNA-binding protein implicated in immune homeostasis and various cancers, including colorectal cancer. HuR binding to AU-rich elements within the 3'…”
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Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis by Blanco, Fernando F, Preet, Ranjan, Aguado, Andrea, Vishwakarma, Vikalp, Stevens, Laura E, Vyas, Alok, Padhye, Subhash, Xu, Liang, Weir, Scott J, Anant, Shrikant, Meisner-Kober, Nicole, Brody, Jonathan R, Dixon, Dan A

“…Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of…”
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Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors by Chand, Saswati N, Zarei, Mahsa, Schiewer, Matthew J, Kamath, Akshay R, Romeo, Carmella, Lal, Shruti, Cozzitorto, Joseph A, Nevler, Avinoam, Scolaro, Laura, Londin, Eric, Jiang, Wei, Meisner-Kober, Nicole, Pishvaian, Michael J, Knudsen, Karen E, Yeo, Charles J, Pascal, John M, Winter, Jordan M, Brody, Jonathan R

“…The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show…”
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Synergy of Human Platelet-Derived Extracellular Vesicles with Secretome Proteins Promotes Regenerative Functions by Gomes, Fausto Gueths, Andrade, André Cronemberger, Wolf, Martin, Hochmann, Sarah, Krisch, Linda, Maeding, Nicole, Regl, Christof, Poupardin, Rodolphe, Ebner-Peking, Patricia, Huber, Christian G, Meisner-Kober, Nicole, Schallmoser, Katharina, Strunk, Dirk

“…Platelet-rich plasma is a promising regenerative therapeutic with controversial efficacy. We and others have previously demonstrated regenerative functions of…”
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High efficiency preparation of monodisperse plasma membrane derived extracellular vesicles for therapeutic applications by Alter, Claudio L., Detampel, Pascal, Schefer, Roman B., Lotter, Claudia, Hauswirth, Patrick, Puligilla, Ramya D., Weibel, Vera J., Schenk, Susanne H., Heusermann, Wolf, Schürz, Melanie, Meisner-Kober, Nicole, Palivan, Cornelia, Einfalt, Tomaž, Huwyler, Jörg

“…Extracellular vesicles (EVs) are highly interesting for the design of next-generation therapeutics. However, their preparation methods face challenges in…”
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Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review by Lima, Thais S M, Souza, Wanderson, Geaquinto, Luths R O, Sanches, Priscila L, Stepień, Ewa L, Meneses, João, Fernández-de Gortari, Eli, Meisner-Kober, Nicole, Himly, Martin, Granjeiro, José M, Ribeiro, Ana R

“…The progressively increasing use of nanomaterials (NMs) has awakened issues related to nanosafety and its potential toxic effects on human health. Emerging…”
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Novel 1:1 Labeling and Purification Process for C‑Terminal Thioester and Single Cysteine Recombinant Proteins Using Generic Peptidic Toolbox Reagents by Portal, Christophe F, Seifert, Jan-Marcus, Buehler, Christof, Meisner-Kober, Nicole-Claudia, Auer, Manfred

“…We developed a versatile set of chemical labeling reagents which allow dye ligation to the C-terminus of a protein or a single internal cysteine and target…”
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Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop by Paolini, Lucia, Monguió‐Tortajada, Marta, Costa, Marta, Antenucci, Fabio, Barilani, Mario, Clos‐Sansalvador, Marta, Andrade, André Cronemberger, Driedonks, Tom A. P., Giancaterino, Sara, Kronstadt, Stephanie M., Mizenko, Rachel R., Nawaz, Muhammad, Osteikoetxea, Xabier, Pereira, Carla, Shrivastava, Surya, Boysen, Anders Toftegaard, Wakker, Simonides Immanuel, Herwijnen, Martijn J. C., Wang, Xiaoqin, Watson, Dionysios C., Gimona, Mario, Kaparakis‐Liaskos, Maria, Konstantinov, Konstantin, Lim, Sai Kiang, Meisner‐Kober, Nicole, Stork, Michiel, Nejsum, Peter, Radeghieri, Annalisa, Rohde, Eva, Touzet, Nicolas, Wauben, Marca H. M., Witwer, Kenneth W., Bongiovanni, Antonella, Bergese, Paolo

“…Extracellular vesicles (EVs) large‐scale production is a crucial point for the translation of EVs from discovery to application of EV‐based products. In…”
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Quantitative and functional characterisation of extracellular vesicles after passive loading with hydrophobic or cholesterol-tagged small molecules by Tréton, Gwenola, Sayer, Claudia, Schürz, Melanie, Jaritsch, Maria, Müller, Anna, Matea, Cristian-Tudor, Stanojlovic, Vesna, Melo-Benirschke, Heloisa, Be, Celine, Krembel, Caroline, Rodde, Stephane, Haffke, Matthias, Hintermann, Samuel, Marzinzik, Andreas, Ripoche, Sébastien, Blöchl, Constantin, Hollerweger, Julia, Auer, Daniela, Cabrele, Chiara, Huber, Christian G., Hintersteiner, Martin, Wagner, Trixie, Lingel, Andreas, Meisner-Kober, Nicole

“…Extracellular vesicles (EVs) are nanosized intercellular messengers that bear enormous application potential as biological drug delivery vehicles. Much…”
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Surface display of functional moieties on extracellular vesicles using lipid anchors by Zheng, Wenyi, Schürz, Melanie, Wiklander, Rim Jawad, Gustafsson, Oskar, Gupta, Dhanu, Slovak, Radka, Traista, Andrei, Coluzzi, Arianna, Roudi, Samantha, Barone, Antonella, Farcas, Daria, Kyriakopoulou, Eleni, Galli, Valentina, Sharma, Heena, Meisner-Kober, Nicole, Honcharenko, Malgorzata, Andaloussi, Samir E.L.

“…Extracellular vesicles (EVs) are efficient natural vehicles for intercellular communication and are under extensive investigation for the delivery of diverse…”
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HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells by Romeo, Carmella, Weber, Matthew C, Zarei, Mahsa, DeCicco, Danielle, Chand, Saswati N, Lobo, Angie D, Winter, Jordan M, Sawicki, Janet A, Sachs, Jonathan N, Meisner-Kober, Nicole, Yeo, Charles J, Vadigepalli, Rajanikanth, Tykocinski, Mark L, Brody, Jonathan R

“…Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers, in part, due to resistance to both conventional and targeted therapeutics. TRAIL…”
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