Search Results - "Meisburger, Steve P"

Determining the Locations of Ions and Water around DNA from X-Ray Scattering Measurements by Meisburger, Steve P., Pabit, Suzette A., Pollack, Lois

“…Nucleic acids carry a negative charge, attracting salt ions and water. Interactions with these components of the solvent drive DNA to condense, RNA to fold,…”
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Diffuse X-ray scattering from correlated motions in a protein crystal by Meisburger, Steve P., Case, David A., Ando, Nozomi

“…Protein dynamics are integral to biological function, yet few techniques are sensitive to collective atomic motions. A long-standing goal of X-ray…”
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Robust total X-ray scattering workflow to study correlated motion of proteins in crystals by Meisburger, Steve P., Case, David A., Ando, Nozomi

“…The breathing motions of proteins are thought to play a critical role in function. However, current techniques to study key collective motions are limited to…”
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X‑ray Scattering Studies of Protein Structural Dynamics by Meisburger, Steve P, Thomas, William C, Watkins, Maxwell B, Ando, Nozomi

“…X-ray scattering is uniquely suited to the study of disordered systems and thus has the potential to provide insight into dynamic processes where diffraction…”
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Ionic strength-dependent persistence lengths of single-stranded RNA and DNA by Chen, Huimin, Meisburger, Steve P, Pabit, Suzette A, Sutton, Julie L, Webb, Watt W, Pollack, Lois

“…Dynamic RNA molecules carry out essential processes in the cell including translation and splicing. Base-pair interactions stabilize RNA into relatively rigid…”
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Asymmetric unwrapping of nucleosomal DNA propagates asymmetric opening and dissociation of the histone core by Chen, Yujie, Tokuda, Joshua M., Topping, Traci, Meisburger, Steve P., Pabit, Suzette A., Gloss, Lisa M., Pollack, Lois

“…The nucleosome core particle (NCP) is the basic structural unit for genome packaging in eukaryotic cells and consists of DNA wound around a core of eight…”
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Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X‑ray Scattering by Meisburger, Steve P, Taylor, Alexander B, Khan, Crystal A, Zhang, Shengnan, Fitzpatrick, Paul F, Ando, Nozomi

“…Mammalian phenylalanine hydroxylase (PheH) is an allosteric enzyme that catalyzes the first step in the catabolism of the amino acid phenylalanine. Following…”
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RNA and Its Ionic Cloud: Solution Scattering Experiments and Atomically Detailed Simulations by Kirmizialtin, Serdal, Pabit, Suzette A., Meisburger, Steve P., Pollack, Lois, Elber, Ron

“…RNA molecules play critical roles in many cellular processes. Traditionally viewed as genetic messengers, RNA molecules were recently discovered to have…”
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REGALS : a general method to deconvolve X-ray scattering data from evolving mixtures by Meisburger, Steve P, Xu, Da, Ando, Nozomi

“…Mixtures of biological macromolecules are inherently difficult to study using structural methods, as increasing complexity presents new challenges for data…”
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Breaking the Radiation Damage Limit with Cryo-SAXS by Meisburger, Steve P., Warkentin, Matthew, Chen, Huimin, Hopkins, Jesse B., Gillilan, Richard E., Pollack, Lois, Thorne, Robert E.

“…Small angle x-ray scattering (SAXS) is a versatile and widely used technique for obtaining low-resolution structures of macromolecules and complexes. SAXS…”
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Small-Angle X-ray Scattering and Single-Molecule FRET Spectroscopy Produce Highly Divergent Views of the Low-Denaturant Unfolded State by Yoo, Tae Yeon, Meisburger, Steve P., Hinshaw, James, Pollack, Lois, Haran, Gilad, Sosnick, Tobin R., Plaxco, Kevin

“…The results of more than a dozen single-molecule Förster resonance energy transfer (smFRET) experiments suggest that chemically unfolded polypeptides…”
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Correlated Motions in Structural Biology by Xu, Da, Meisburger, Steve P, Ando, Nozomi

“…Correlated motions in proteins arising from the collective movements of residues have long been proposed to be fundamentally important to key properties of…”
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Scaling and merging macromolecular diffuse scattering with mdx2 by Meisburger, Steve P., Ando, Nozomi

“…Diffuse scattering is a promising method to gain additional insight into protein dynamics from macromolecular crystallography experiments. Bragg intensities…”
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Visualizing single-stranded nucleic acids in solution by Plumridge, Alex, Meisburger, Steve P, Pollack, Lois

“…Single-stranded nucleic acids (ssNAs) are ubiquitous in many key cellular functions. Their flexibility limits both the number of high-resolution structures…”
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The impact of base stacking on the conformations and electrostatics of single-stranded DNA by Plumridge, Alex, Meisburger, Steve P, Andresen, Kurt, Pollack, Lois

“…Single-stranded DNA (ssDNA) is notable for its interactions with ssDNA binding proteins (SSBs) during fundamentally important biological processes including…”
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Correlated motions in enzymes by Ando, Nozomi, Meisburger, Steve P., Case, David A.

“…Correlated motions in proteins arising from the collective movements of residues have long been proposed to be fundamentally important to key properties of…”
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Correlated Motions from Crystallography beyond Diffraction by Meisburger, Steve P, Ando, Nozomi

“…Over the past century, X-ray crystallography has been defined by a pursuit for perfection and high resolution. The next Holy Grail of crystallography is to…”
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Processing macromolecular diffuse scattering data by Meisburger, Steve P, Ando, Nozomi

“…Diffuse scattering is a powerful technique to study disorder and dynamics of macromolecules at atomic resolution. Although diffuse scattering is always present…”
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The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability by Khan, Crystal A., Meisburger, Steve P., Ando, Nozomi, Fitzpatrick, Paul F.

“…The naturally occurring R68S substitution of phenylalanine hydroxylase (PheH) causes phenylketonuria (PKU). However, the molecular basis for how the R68S…”
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Revealing transient structures of nucleosomes as DNA unwinds by Chen, Yujie, Tokuda, Joshua M, Topping, Traci, Sutton, Julie L, Meisburger, Steve P, Pabit, Suzette A, Gloss, Lisa M, Pollack, Lois

“…The modulation of DNA accessibility by nucleosomes is a fundamental mechanism of gene regulation in eukaryotes. The nucleosome core particle (NCP) consists of…”
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