Search Results - "Meirena, D."

Paradoxical effects of two oximes on nitric oxide production by purified NO synthases, in cell culture and in animals by Sjakste, N., Andrianov, V.G., Boucher, J.-L., Shestakova, I., Baumane, L., Dzintare, M., Meirena, D., Kalvinsh, I.

“…We have studied the impact of two novel compounds TO-85 (2,6-di-(α-aziridino-α-hydroxyiminomethyl)pyridine and TO-133 (bis-(diaziridinoglyoximato)copper),…”
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Increased synthesis of nitric oxide in rat brain cortex due to halogenated volatile anesthetics confirmed by EPR spectroscopy by Baumane, L., Dzintare, M., Zvejniece, L., Meirena, D., Lauberte, L., Sile, V., Kalvinsh, I., Sjakste, N.

“…Background: Halogenated volatile anesthetics (HVAs) are considered to be inhibitors of nitric oxide synthase (NOS). On other hand, NO mediates the vasodilation…”
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The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats by Sharipova, E. M., Salna, E. V., Dzintare, M. Ya, Lauberte, L. Ya, Meirena, D. V., Sjakste, N. I., Gordjushina, V. S., Kalvinsh, I.

“…The effects of mildronate [3(2,2,2-trimethylhydrazinium) propionate dihydrate], γ-butyrobetaine (GBB) and their combination (neomildronate) on the level of…”
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3-(2,2,2-Trimethylhydrazinium)propionate (THP)--a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties by Simkhovich, B Z, Shutenko, Z V, Meirena, D V, Khagi, K B, Mezapuķe, R J, Molodchina, T N, Kalviņs, I J, Lukevics, E

“…A protein fraction containing gamma-butyrobetaine hydroxylase (sp.act. 1.54 mU/mg) was isolated from the rat liver by differential precipitation with ammonium…”
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Putative role of nitric oxide synthase isoforms in the changes of nitric oxide concentration in rat brain cortex and cerebellum following sevoflurane and isoflurane anaesthesia by Sjakste, Nikolajs, Sjakste, Jelizaveta, Boucher, Jean-Luc, Baumane, Larisa, Sjakste, Tatjana, Dzintare, Maija, Meirena, Dainuvite, Sharipova, Jelena, Kalvinsh, Ivars

“…We have previously observed an increase in nitric oxide (NO) content in rat brain cortex following halothane, sevoflurane or isoflurane anaesthesia. This study…”
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Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate by Sjakste, Nikolajs, Kleschyov, Andrei L, Boucher, Jean-Luc, Baumane, Larisa, Dzintare, Maija, Meirena, Dainuvite, Sjakste, Jelizaveta, Sydow, Karsten, Münzel, Thomas, Kalvinsh, Ivars

“…Mildronate [3-(2,2,2-trimethylhydrazine) propionate (THP)] is an antiischemic drug acting mainly via inhibition of fatty acid β-oxidation. Some effects of the…”
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Effects of γ‐Butyrobetaine and Mildronate on Nitric Oxide Production in Lipopolysaccharide‐Treated Rats by Sjakste, Nikolajs, Baumane, Larisa, Boucher, Jean‐Luc, Dzintare, Maija, Meirena, Dainuvite, Sjakste, Jelizaveta, Lauberte, Lasma, Kalvinsh, Ivars

“…: Production of nitric oxide was measured in lipopolysaccharide‐treated rats (10 mg/kg, 4 hr) using the electron paramagnetic resonance method. As compared to…”
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Drastic increase in nitric oxide content in rat brain under halothane anesthesia revealed by EPR method by Sjakste, Nikolajs, Baumane, Larisa, Meirena, Dainuvı̄te, Ļauberte, Lāsma, Dzintare, Maija, Kalviņs̆, Ivars

“…A drastic increase in nitric oxide (NO) content was revealed by the EPR method in rat brain cortex and cerebellum under halothane anesthesia. The NO scavenger…”
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Cardioprotective effects of N‐hydroxyguanidine PR5 in myocardial ischaemia and reperfusion in rats by Veveris, Maris, Dambrova, Maija, Cirule, Helena, Meirena, Dainuvite, Kalvinsh, Ivars, Wikberg, Jarl E S

“…The potential for the N‐hydroxyguanidine compound PR5 (N‐(3,4‐dimethoxy‐2‐chlorobenzylideneamino)‐N′‐hydroxyguanidine) as a cardioprotective agent in heart…”
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Role of nitric oxide (NO) in the mechanism of anesthetic action by Sjakste, N, Dzintare, M, Baumane, L, Meirena, D, Lauberte, L, Kalvinś, I

“…Published reports on modifications of nitric oxide (NO) synthase (NOS) activity and NO production in the brain during development of anesthesia induced by the…”
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Effect of doprostone on fatty acid metabolism disturbances in the rat heart caused by adrenergic influences by Simkhovich, B Z, Meĭrena, D V, Khagi, Kh B, Freĭmanis, Ia F

“…Administration of isoproterenol results in a marked increase (by 4.85 times) of the blood serum concentration of free fatty acids. In the heart there was found…”
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The pharmacokinetics of 5-fluorouracil-2-C14 by Gilev, A. P., Meirena, D. V., Khagi, Kh. B., Koptelova, M. N., Shafro, . A.

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Comparative study of the antioxidant activity of gamma-butyrobetaine and its natural and synthetic derivatives in vitro by Shutenko, Z I, Aparneva, D A, Meirena, D V, Strump, A V, Venediktova, S G, Ozola, R A, Kal'vinsh, I Y

“…Experiments in vitro with the use of a rat brain homogenate demonstrated antioxidant activity of methyl ether (3(2,2,2-trimethylhydrazinium) propionate…”
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Mildronate: Mechanisms of action and prospects for correction of pathologic states by Shutenko, Zh. V., Meirena, D. V., Kagan, T. I., S'yakste, N. I., Kalvin'sh, I. Ya

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1-(5-fluorouracil-1-yl)-2,5-di-0-acetyl-β-d-glucofuranurono-6,3-lactone, a new transport form of 5-fluorouracil by Maurin'sh, Yu. A., Paégle, R. A., Khagi, Kh. V., Meirena, D. V., Simkhovich, B. Z., Lidak, M. Yu

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Analogs of pyrimidine nucleosides. 19. Synthesis, antineoplastic activity, and kinetics of the hydrolysis of 1-(3-phthalidyl)-5-fluorouracils by Zhuk, R. A., Ludzisha, A. S., Shpaer, E. G., Lidak, M. Yu, Zidermane, A. A., Meirena, D. V.

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Absorption and excretion of [14C] sidnocarb from the rat organism by Al'tshuler, R. A., Kholodov, L. E., Gilev, A. P., Meirena, D. V., Odynets, A. G.

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Distribution of f[14C] sidnokarb in the rat organism by Al'tshuler, R. A., Kholodov, L. E., Meirena, D. V., Seredenin, S. B., Sultanov, I. A., Stelletskaya, N. V., Blednov, Yu. A.

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Prevention of ischemic myocardial damage by reducing the intracellular free carnitine level by Simkhovich, B Z, Vitolinia, R O, Stivrinia, M I, Shutenko, Zh V, Meĭrena, D V

“…3-(2, 2, 2-trimethylhydrazinium) propionate (THP) inhibits gamma-butyrobetaine hydroxylase, which is accompanied by a drop in myocardial free carnitin content…”
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Potentiation of the antiketogenic effect of exogenous glucose with the help of the new beta-oxidation inhibitor mildronate--3-(2,2,2-trimethylhydrazine)propionate by Shutenko, Zh V, Meĭrena, D V, Kalvin'sh, I Ia, Lukevits, E Ia

“…Antiketogenic effect of exogenous glucose (2 g/kg, per os, 1 hr before death) was potentiated after preadministration of mildronate…”
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