Search Results - "Meinkoth, Judy L"

Histone deacetylase is a target of valproic acid-mediated cellular differentiation by GURVICH, Nadia, TSYGANKOVA, Oxana M, MEINKOTH, Judy L, KLEIN, Peter S

“…Valproic acid (VPA), a well-established therapy for seizures and bipolar disorder, has recently been shown to inhibit histone deacetylases (HDACs). Similar to…”
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Tumor Cell Migration and Invasion Are Enhanced by Depletion of Rap1 GTPase-activating Protein (Rap1GAP) by Tsygankova, Oxana M., Wang, Hongbin, Meinkoth, Judy L.

“…The functional significance of the widespread down-regulation of Rap1 GTPase-activating protein (Rap1GAP), a negative regulator of Rap activity, in human…”
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Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells by Dong, Xiaoyun, Korch, Christopher, Meinkoth, Judy L

“…Increases in Rap activity have been associated with tumor progression. Although activating mutations in Rap have not been described, downregulation of Rap1GAP…”
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Downregulation of Rap1GAP in Human Tumor Cells Alters Cell/Matrix and Cell/Cell Adhesion by Tsygankova, Oxana M., Ma, Changqing, Tang, Waixing, Korch, Christopher, Feldman, Michael D., Lv, Yu, Brose, Marcia S., Meinkoth, Judy L.

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Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin by Vuchak, Lisa A, Tsygankova, Oxana M, Prendergast, Gregory V, Meinkoth, Judy L

“…Thyrotropin (TSH) regulates thyroid cell proliferation and function through cAMP-mediated signaling pathways that activate protein kinase A (PKA) and…”
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Downregulation of Rap1GAP Contributes to Ras Transformation by Tsygankova, Oxana M., Prendergast, Gregory V., Puttaswamy, Kanchan, Wang, Yan, Feldman, Michael D., Wang, Hongbin, Brose, Marcia S., Meinkoth, Judy L.

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Loss of Rap1GAP in Papillary Thyroid Cancer by Nellore, Anoma, Paziana, Karolina, Ma, Changqing, Tsygankova, Oxana M., Wang, Yan, Puttaswamy, Kanchan, Iqbal, Ammarah U., Franks, Susanna R., Lv, Yu, Troxel, Andrea B., Feldman, Michael D., Meinkoth, Judy L., Brose, Marcia S.

“…Context: Rap1 GTPase-activating protein (GAP) regulates the activity of Rap1, a putative oncogene. We previously reported Rap1GAP was highly expressed in…”
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Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion by Vuchak, Lisa A., Tsygankova, Oxana M., Meinkoth, Judy L.

“…The significance of the widespread downregulation of Rap1GAP in human tumors is unknown. In previous studies we demonstrated that silencing Rap1GAP expression…”
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Ras Triggers Ataxia-telangiectasia-mutated and Rad-3-related Activation and Apoptosis through Sustained Mitogenic Signaling by Fikaris, Aphrothiti J., Lewis, Aurélia E., Abulaiti, Adili, Tsygankova, Oxana M., Meinkoth, Judy L.

“…Genetic evidence indicates that Ras plays a critical role in the initiation and progression of human thyroid tumors. Paradoxically, acute expression of…”
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Lysophosphatidic Acid Promotes Survival and Differentiation of Rat Schwann Cells by Li, Yiwen, Gonzalez, Marco I, Meinkoth, Judy L, Field, Jeffrey, Kazanietz, Marcelo G, Tennekoon, Gihan I

“…Lysophosphatidic acid (LPA; 1-acyl- sn -glycerol-3-phosphate), an abundant constituent of serum, mediates multiple biological responses via G protein-coupled…”
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RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells by Dong, Xiaoyun, Tang, Waixing, Stopenski, Stephen, Brose, Marcia S, Korch, Christopher, Meinkoth, Judy L

“…The functional significance of decreased RAP1GAP protein expression in human tumors is unclear. To identify targets of RAP1GAP downregulation in the thyroid…”
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Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation by Mei, Fang C, Qiao, Jingbo, Tsygankova, Oxana M, Meinkoth, Judy L, Quilliam, Lawrence A, Cheng, Xiaodong

“…The recent discovery of Epac, a novel cAMP receptor protein, opens up a new dimension in studying cAMP-mediated cell signaling. It is conceivable that many of…”
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Ras induces chromosome instability and abrogation of the DNA damage response by ABULAITI, Adili, FIKARIS, Aphrothiti J, TSYGANKOVA, Oxana M, MEINKOTH, Judy L

“…Ras mutations are frequent in thyroid tumors, the most common endocrine malignancy. The ability of Ras to transform thyroid cells is thought to rely on its…”
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Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest by Santiago-Walker, Ademi E., Fikaris, Aphrothiti J., Kao, Gary D., Brown, Eric J., Kazanietz, Marcelo G., Meinkoth, Judy L.

“…Overexpression of protein kinase C δ (PKCδ) stimulates apoptosis in a wide variety of cell types through a mechanism that is incompletely understood…”
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Protein Kinase A-Dependent and -Independent Signaling Pathways Contribute to Cyclic AMP-Stimulated Proliferation by Cass, Lisa A., Summers, Scott A., Prendergast, Gregory V., Backer, Jonathan M., Birnbaum, Morris J., Meinkoth, Judy L.

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Coordinated Regulation of Rap1 and Thyroid Differentiation by Cyclic AMP and Protein Kinase A by Tsygankova, Oxana M., Saavedra, Arturo, Rebhun, John F., Quilliam, Lawrence A., Meinkoth, Judy L.

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TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion by Smirnova, Evgeniya V, Collingwood, Therese S, Bisbal, Catherine, Tsygankova, Oxana M, Bogush, Marina, Meinkoth, Judy L, Henderson, Earl E, Annan, Roland S, Tsygankov, Alexander Y

“…Abstract TULA, a recently identified UBA- and SH3-containing protein, has previously been shown to regulate cell signaling through protein tyrosine kinases. In…”
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Differential Effects of Cyclic Adenosine 3′,5′-Monophosphate on p70 Ribosomal S6 Kinase by Cass, Lisa A., Meinkoth, Judy L.

“…Abstract cAMP exerts differential effects on mitogenic signaling pathways. In many cells, cAMP inhibits growth factor-stimulated MAPK activity and…”
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Interference with 3′,5′-Cyclic Adenosine Monophosphate Response Element Binding Protein Stimulates Apoptosis through Aberrant Cell Cycle Progression and Checkpoint Activation by Dworet, Jessica H, Meinkoth, Judy L

“…We previously reported that protein kinase A activity is an important determinant of thyroid cell survival. Given the important role of cAMP response element…”
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Biology of Ras in thyroid cells by Meinkoth, Judy L

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