Search Results - "Meini, S"

Knee osteoarthritis: a role for bradykinin? by Meini, S., Maggi, C. A.

“… Osteoarthritis (OA) is a painful and degenerating progressive disease of the joints which affects millions of patients worldwide. The cause of OA is largely…”
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Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritis by Bellucci, F, Meini, S, Cucchi, P, Catalani, C, Nizzardo, A, Riva, A, Guidelli, G.M, Ferrata, P, Fioravanti, A, Maggi, C.A

“…Summary Objective To determine the content of bradykinin (BK) and markers of cartilage degradation and inflammation in the synovial fluid (SF) of patients with…”
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Blockade of nociceptive sensory afferent activity of the rat knee joint by the bradykinin B2 receptor antagonist fasitibant by Gomis, A, Meini, S, Miralles, A, Valenti, C, Giuliani, S, Belmonte, C, Maggi, C.A

“…Summary Objective The aim of this study was to determine in intact and inflamed knee joints of the rat, the effect of the bradykinin (BK) B2 receptor…”
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Bradykinin and B 2 receptor antagonism in rat and human articular chondrocytes by Meini, S, Cucchi, P, Catalani, C, Bellucci, F, Giuliani, S, Maggi, CA

“…BACKGROUND AND PURPOSE In osteoarthritis (OA), bradykinin (BK) is known to contribute to pain and synovitis, but not to cartilage degradation. Here, we…”
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Gender‐related differential effect of tachykinin NK2 receptor‐mediated visceral hyperalgesia in guinea pig colon by Bellucci, F, Buéno, L, Bugianesi, R, Crea, A, D'Aranno, V, Meini, S, Santicioli, P, Tramontana, M, Maggi, CA

“…Background and Purpose The tachykinin NK2 receptor antagonist ibodutant is under Phase III clinical investigation to treat female patients with irritable bowel…”
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Long-term clinical outcomes in critical limb ischemia--A retrospective study of 181 patients by Melillo, E, Micheletti, L, Nuti, M, Dell'Omo, G, Berchiolli, R, Adami, D, Farina, A, Panigada, G, Meini, S

“…Critical limb ischemia (CLI) is the most severe manifestation of the peripheral arterial disease. To date, several prognostic factors have been identified but…”
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Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B 2 receptor antagonism in human synovial fibroblasts by Bellucci, F, Cucchi, P, Catalani, C, Giuliani, S, Meini, S, Maggi, CA

“…Background and purpose:  Bradykinin (BK) and B 2 receptors have been implicated in the pathophysiology of osteoarthritis (OA), and synovitis is one of its…”
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Serum biomarkers detection clusters improve the detection of symptomatic treatment effect in knee osteoarthitis patients: the results of a phase ib/iia study with the b2 receptor antagonist fasitibant by Meini, S, Bellucci, F, Cucchi, P, Catalani, C, Nizzardo, A, Rossi, C, Capriati, A, Maggi, C.A

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Long-term survival of patients with critical limb ischemia treated with iloprost: response rate and predictive criteria. A retrospective analysis of 102 patients by Melillo, E, Lucaccini, E, Berchiolli, R, Adami, D, Nuti, M, Dell'Omo, G, Farina, A, Panigada, G, Roberts, A T, Meini, S

“…Critical limb ischemia (CLI) patients have poor long-term prognosis. We showed that iloprost improves outcomes (major amputation and survival) up a 5-year…”
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Draft Genome Sequence of Clostridium difficile Belonging to Ribotype 018 and Sequence Type 17 by Riccobono, E, Di Pilato, V, Della Malva, N, Meini, S, Ciraolo, F, Torricelli, F, Rossolini, G M

“…Clostridium difficile, belonging to ribotype 018 (RT018), is one of the most prevalent genotypes circulating in hospital settings in Italy. Here, we report the…”
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Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E2 release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes by Meini, S., Cucchi, P., Tinti, L., Niccolini, S., Bellucci, F., Catalani, C., Valenti, C., Galeazzi, M., Fioravanti, A., Maggi, C. A.

“…This study investigates the effect of the selective and potent B 2 receptor antagonist fasitibant (MEN16132) on the proinflammatory effect of bradykinin (BK)…”
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Comparison of the molecular interactions of two antagonists, MEN16132 or icatibant, at the human kinin B 2 receptor by Meini, S, Bellucci, F, Catalani, C, Cucchi, P, Giolitti, A, Giuliani, S, Quartara, L, Rotondaro, L, Zappitelli, S, Maggi, CA

“…BACKGROUND AND PURPOSE Icatibant is a well‐known kinin B 2 receptor antagonist currently used for angiooedema attacks. MEN16132 is a non‐peptide B 2 receptor…”
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220 BRADYKININ, THROUGH B2 RECEPTORS, ACTIVATES THE RELEASE OF THE CYTOKINE INTERLEUKIN 6, THE CHEMOKINE INTERLEUKIN 8, AND THE METALLOPROTEINASE 3 IN HUMAN KNEE CHONDROCYTES by Meini, S, Cucchi, P, Bellucci, F, Catalani, C, Giuliani, S, Maggi, C.A

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Bradykinin and B2 receptor antagonism in rat and human articular chondrocytes by Meini, S, Cucchi, P, Catalani, C, Bellucci, F, Giuliani, S, Maggi, CA

“…BACKGROUND AND PURPOSE In osteoarthritis (OA), bradykinin (BK) is known to contribute to pain and synovitis, but not to cartilage degradation. Here, we…”
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Takayasu’s Arteritis: The “Macaroni Sign” by Meini, S., De Franco, V., Auteri, A., Pieragalli, D.

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Characterization of kinin receptors in human cultured detrusor smooth muscle cells by Bellucci, F, Cucchi, P, Santicioli, P, Lazzeri, M, Turini, D, Meini, S

“…Background and purpose: Kinins have an important role in inflammatory cystitis and in animal pathophysiological models, by acting on epithelium, fibroblasts,…”
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Comparative antagonist pharmacology at the native mouse bradykinin B 2 receptor: radioligand binding and smooth muscle contractility studies by Meini, S, Cucchi, P, Bellucci, F, Catalani, C, Giuliani, S, Santicioli, P, Maggi, C A

“…Background and purpose: The aim was to characterize the recently discovered non‐peptide antagonist MEN16132 at the mouse B 2 receptor, relative to other…”
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432 BRADYKININ AND B2 RECEPTOR ANTAGONISM IN HUMAN KNEE SYNOVIOCYTES AND CHONDROCYTES by Meini, S, Bellucci, F, Catalani, C, Cucchi, P, Giuliani, S, Maggi, C.A

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455 BRADYKININ VIA THE B2 RECEPTOR SYNERGISTICALLY POTENTIATES THE INTERLEUKIN 1 ACTIVATED RELEASE OF PROSTAGLANDIN E2 AND CYCLOOXYGENASE EXPRESSION IN HUMAN-FIBROBLAST LIKE SYNOVIOCYTES by Meini, S, Cucchi, P, Tinti, L, Niccolini, S, Muscari, I, Bellucci, F, Catalani, C, Giuliani, S, Galeazzi, M, Fioravanti, A, Maggi, C.A

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Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease by Di Paolo, N, Bocci, V, Salvo, D P, Palasciano, G, Biagioli, M, Meini, S, Galli, F, Ciari, I, Maccari, F, Cappelletti, F, Di Paolo, M, Gaggiotti, E

“…Since 1990 our group has been using extracorporeal circulation to ozonate blood by an original method, known as extracorporeal blood oxygenation and ozonation…”
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