Search Results - "Meinhardt, Sarah"

Rheostats and toggle switches for modulating protein function by Meinhardt, Sarah, Manley, Jr, Michael W, Parente, Daniel J, Swint-Kruse, Liskin

“…The millions of protein sequences generated by genomics are expected to transform protein engineering and personalized medicine. To achieve these goals, tools…”
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Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression by Meinhardt, Sarah, Manley, Jr, Michael W, Becker, Nicole A, Hessman, Jacob A, Maher, 3rd, L James, Swint-Kruse, Liskin

“…LacI/GalR transcription regulators have extensive, non-conserved interfaces between their regulatory domains and the 18 amino acids that serve as 'linkers' to…”
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Comparing the Functional Roles of Nonconserved Sequence Positions in Homologous Transcription Repressors: Implications for Sequence/Function Analyses by Tungtur, Sudheer, Meinhardt, Sarah, Swint-Kruse, Liskin

“…The explosion of protein sequences deduced from genetic code has led to both a problem and a potential resource: Efficient data use requires interpreting the…”
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Fructose-1-kinase has pleiotropic roles in Escherichia coli by Weeramange, Chamitha, Menjivar, Cindy, O’Neil, Pierce T., El Qaidi, Samir, Harrison, Kelly S., Meinhardt, Sarah, Bird, Cole L., Sreenivasan, Shwetha, Hardwidge, Philip R., Fenton, Aron W., Hefty, P. Scott, Bose, Jeffrey L., Swint-Kruse, Liskin

“…In Escherichia coli, the master transcription regulator catabolite repressor activator (Cra) regulates >100 genes in central metabolism. Cra binding to DNA is…”
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Modular, Multi-Input Transcriptional Logic Gating with Orthogonal LacI/GalR Family Chimeras by Shis, David L, Hussain, Faiza, Meinhardt, Sarah, Swint-Kruse, Liskin, Bennett, Matthew R

“…In prokaryotes, the construction of synthetic, multi-input promoters is constrained by the number of transcription factors that can simultaneously regulate a…”
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Experimental identification of specificity determinants in the domain linker of a LacI/GalR protein: Bioinformatics-based predictions generate true positives and false negatives by Meinhardt, Sarah, Swint-Kruse, Liskin

“…In protein families, conserved residues often contribute to a common general function, such as DNA‐binding. However, unique attributes for each homolog (e.g…”
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Rheostats and Toggle Switches for Modifying Protein Function by Meinhardt, Sarah, Manley, Michael W., Parente, Daniel J., Swint-Kruse, Liskin

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