Search Results - "Meingassner, Josef G."

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity by Mao, Xiaohong, Voshol, Hans, Werner, Gudrun, Rot, Antal, Rubic, Tina, Lametschwandtner, Günther, Kund, Julia, Carballido, José M, Meingassner, Josef G, Jost, Sandra, Junt, Tobias, Carballido-Perrig, Nicole, Hinteregger, Sonja, Schwärzler, Christoph

“…Succinate is a Krebs cycle intermediate. Carballido and colleagues show that succinate released by necrotic cells also functions as an 'alarmin' by activating…”
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Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands by Meingassner, Josef G., Aschauer, Heinrich, Winiski, Anthony P., Dales, Natalie, Yowe, David, Winther, Michael D., Zhang, Zaihui, Stütz, Anton, Billich, Andreas

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Signal transducer and activator of transcription 1 decoy oligodeoxynucleotide suppression of contact hypersensitivity by Wagner, Andreas H., PhD, Wittjen, Inka, MD, Stojanovic, Tomislav, MD, Middel, Peter, MD, Meingassner, Josef G., DVM, Hecker, Markus, PhD

“…Background Cytokines play a pivotal role in allergy development through activating signaling mechanisms, such as the Janus kinase/signal transducer and…”
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CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells by Schneider, Martin A, Meingassner, Josef G, Lipp, Martin, Moore, Henrietta D, Rot, Antal

“…CCR7-mediated migration of naive T cells into the secondary lymphoid organs is a prerequisite for their encounter with mature dendritic cells, the productive…”
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Pimecrolimus permeates less than tacrolimus through normal, inflamed, or corticosteroid-pretreated skin by Meingassner, Josef G., Aschauer, Heinrich, Stuetz, Anton, Billich, Andreas

“…:  The permeabilities of normal human and normal, inflamed, or corticosteroid (CS) pretreated skin of young domestic pigs for pimecrolimus and tacrolimus were…”
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Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor by Skvara, Hans, Kalthoff, Frank, Meingassner, Josef G., Wolff-Winiski, Barbara, Aschauer, Heinrich, Kelleher, Joseph F., Wu, Xu, Pan, Shifeng, Mickel, Lesanka, Schuster, Christopher, Stary, Georg, Jalili, Ahmad, David, Olivier J., Emotte, Corinne, Antunes, Ana Monica Costa, Rose, Kristine, Decker, Jeremy, Carlson, Ilene, Gardner, Humphrey, Stuetz, Anton, Bertolino, Arthur P., Stingl, Georg, De Rie, Menno A.

“…Basal cell carcinoma (BCC) is a distinctive manifestation in nevoid basal cell carcinoma syndrome (NBCCS) patients. Both inherited and acquired mutations of…”
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Inhibition of Chronic and Acute Skin Inflammation by Treatment with a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor by Halin, Cornelia, Fahrngruber, Hermann, Meingassner, Josef G, Bold, Guido, Littlewood-Evans, Amanda, Stuetz, Anton, Detmar, Michael

“…Although vascular remodeling is a hallmark of many chronic inflammatory disorders, antivascular strategies to treat these conditions have received little…”
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The PKC inhibitor AEB071 may be a therapeutic option for psoriasis by Skvara, Hans, Dawid, Markus, Kleyn, Elise, Wolff, Barbara, Meingassner, Josef G, Knight, Hilary, Dumortier, Thomas, Kopp, Tamara, Fallahi, Nasanin, Stary, Georg, Burkhart, Christoph, Grenet, Olivier, Wagner, Juergen, Hijazi, Youssef, Morris, Randall E, McGeown, Claire, Rordorf, Christiane, Griffiths, Christopher E M, Stingl, Georg, Jung, Thomas

“…PKC isoforms tau, alpha, and beta play fundamental roles in the activation of T cells and other immune cell functions. Here we show that the PKC inhibitor…”
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Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption by Schmook, Fritz P., Meingassner, Josef G., Billich, Andreas

“…For the study of in-vitro skin penetration of candidate drugs, excised animal skin is frequently used as a replacement for human skin. Reconstructed human skin…”
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Neutropenia with Impaired Immune Response to Streptococcus pneumoniae in Ceramide Kinase-Deficient Mice by Graf, Christine, Zemann, Barbara, Rovina, Philipp, Urtz, Nicole, Schanzer, Andrea, Reuschel, Roland, Mechtcheriakova, Diana, Muller, Matthias, Fischer, Evelin, Reichel, Claudia, Huber, Susanna, Dawson, Janet, Meingassner, Josef G, Billich, Andreas, Niwa, Satoru, Badegruber, Rudolf, Van Veldhoven, Paul P, Kinzel, Bernd, Baumruker, Thomas, Bornancin, Frederic

“…In mammals, ceramide kinase (CerK)-mediated phosphorylation of ceramide is the only known pathway to ceramide-1-phosphate (C1P), a recently identified…”
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Corticosteroids But Not Pimecrolimus Affect Viability, Maturation and Immune Function of Murine Epidermal Langerhans Cells by Hoetzenecker, Wolfram, Meingassner, Josef G., Ecker, Rupert, Stingl, Georg, Stuetz, Anton, Elbe-Bürger, Adelheid

“…Given the importance of dendritic cells in the immune response, we investigated the effect of corticosteroids (CS) on the integrity, survival, and function of…”
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Discovery of topical calcineurin inhibitors and pharmacological profile of pimecrolimus by Stuetz, Anton, Baumann, Karl, Grassberger, Maximilian, Wolff, Klaus, Meingassner, Josef G

“…Using a newly developed model of allergic contact dermatitis in pigs, calcineurin inhibitors of the tacrolimus and ascomycin type were shown to have a highly…”
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Pimecrolimus Inhibits the Elicitation Phase but Does Not Suppress the Sensitization Phase in Murine Contact Hypersensitivity, in Contrast to Tacrolimus and Cyclosporine A by MEINGASSNER, Josef G, FAHRNGRUBER, Hermann, BAVANDI, Assadollah

“…Pimecrolimus (SDZ ASM 981, Elidel) is a nonsteroid inflammatory cytokine inhibitor specifically developed for the treatment of inflammatory skin diseases. Its…”
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Differential Effects of Corticosteroids and Pimecrolimus on the Developing Skin Immune System in Humans and Mice by Meindl, Simone, Vaculik, Christine, Meingassner, Josef G., Kramer, Gero, Akgün, Johnnie, Prior, Marion, Stuetz, Anton, Stingl, Georg, Elbe-Bürger, Adelheid

“…Atopic dermatitis arises primarily in early infancy. In these patients, corticosteroids are used especially with great caution because of their side effects…”
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Expression of Epidermal Keratins and the Cornified Envelope Protein Involucrin is Influenced by Permeability Barrier Disruption by Ekanayake-Mudiyanselage, Swarna, Jensen, Jens-Michael, Proksch, Ehrhardt, Aschauer, Heinrich, Schmook, Fritz P., Meingassner, Josef G.

“…In previous studies we have shown that experimental permeability barrier disruption leads to an increase in epidermal lipid and DNA synthesis. Here we…”
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New Derivatives of Ascomycin with Modifications in the Amino Acid Region - Synthesis and Biological Activities, and X-Ray Crystal Structure of 5,6-Dehydroascomycin by Bulusu, Murty A. R. C., Waldstätten, Peter, Tricotet, Thomas, Rochais, Christophe, Steck, Andrea, Bacher, Markus, Schulz, Gerhard, Meingassner, Josef G., Hiestand, Peter, Zenke, Gerhard, Schuler, Walter, Wagner, Trixie

“…The immunomodulatory macrolide ascomycin (1a) inhibits T‐cell activation via binding to macrophilin‐12 and inhibition of the phosphatase calcineurin. Its…”
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effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superficial keratitis in dogs: results from an exploratory study by Nell, B, Walde, I, Billich, A, Vit, P, Meingassner, J.G

“…Objective Pimecrolimus is an ascomycin derivative that interferes selectively with the activation of T cells and mast cells and inhibits the production of…”
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Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain by Ullrich, Thomas, Baumann, Karl, Welzenbach, Karl, Schmutz, Simone, Camenisch, Gian, Meingassner, Josef G., Weitz-Schmidt, Gabriele

“…The synthesis, biological activity, and microsomal stability of a series of potent LFA-1/ICAM-1 binding inhibitors of the statin family are presented…”
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Synthesis of dammarane-type triterpenoids with anti-inflammatory activity in vivo by Scholz, Dieter, Baumann, Karl, Grassberger, Max, Wolff-Winiski, Barbara, Rihs, Grety, Walter, Hansrudolf, Meingassner, Josef G.

“…The synthesis and in vivo activity of new potent anti-inflammatory triterpenoids are described. The 17-α-substituted triterpene 1 [(17α)-23-(…”
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6-[2-(Adamantylidene)-hydroxybenzoxazole]- O-sulfamate, a steroid sulfatase inhibitor for the treatment of androgen- and estrogen-dependent diseases by Billich, Andreas, Meingassner, Josef G., Nussbaumer, Peter, Desrayaud, Sandrine, Lam, Charles, Winiski, Anthony, Schreiner, Erwin

“…Steroid sulfatase (STS) offers a new target for the treatment of steroid hormone-dependent diseases, such as breast and prostate cancer and androgen-dependent…”
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