Search Results - "Meingassner, J G"

Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption by Schmook, Fritz P., Meingassner, Josef G., Billich, Andreas

“…For the study of in-vitro skin penetration of candidate drugs, excised animal skin is frequently used as a replacement for human skin. Reconstructed human skin…”
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Pimecrolimus does not affect Langerhans cells in murine epidermis by Meingassner, J.G., Kowalsky, E., Schwendinger, H., Elbe-Bürger, A., Stütz, A.

“…Summary Background  Langerhans cells (LCs) function as specialized antigen‐presenting cells in the epidermis, and therefore play a critical role in cutaneous…”
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A novel anti-inflammatory drug, SDZ ASM 981, for the topical and oral treatment of skin diseases: in vivo pharmacology by MEINGASSNER, J.G., GRASSBERGER, M., FAHRNGRUBER, H., MOORE, H.D., SCHUURMAN, H., STÜTZ, A.

“…Summary There is a need for safe and effective therapies for inflammatory skin diseases. Current topical and systemic treatment of psoriasis is effective but…”
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Pimecrolimus (Elidel, SDZ ASM 981)--preclinical pharmacologic profile and skin selectivity by Stuetz, A, Grassberger, M, Meingassner, J G

“…The ascomycin macrolactam derivative pimecrolimus (Elidel, SDZ ASM 981; Novartis Pharma AG, Basel Switzerland) is a cell-selective inhibitor of inflammatory…”
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Excretion of corticosteroid metabolites in urine and faeces of rats by Bamberg, E, Palme, R, Meingassner, J G

“…Stress enhances the production of corticosteroids by the adrenal cortex, resulting in the increased excretion of their metabolites in urine and faeces. An…”
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Morphologic and Immunohistochemical Features of Experimentally Induced Allergic Contact Dermatitis in Göttingen Minipigs by Vana, G., Meingassner, J. G.

“…Many preclinical studies in investigative dermatology are performed preferably in pigs because pig skin is more similar to human skin than is rodent skin. A…”
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Expression of Epidermal Keratins and the Cornified Envelope Protein Involucrin is Influenced by Permeability Barrier Disruption by Ekanayake-Mudiyanselage, Swarna, Jensen, Jens-Michael, Proksch, Ehrhardt, Aschauer, Heinrich, Schmook, Fritz P., Meingassner, Josef G.

“…In previous studies we have shown that experimental permeability barrier disruption leads to an increase in epidermal lipid and DNA synthesis. Here we…”
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Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner by HULTSCH, T, MÜLLER, K. D, MEINGASSNER, J. G, GRASSBERGER, M, SCHOPF, R. E, KNOP, J

“…Mast cells play an important role in the pathological development of many inflammatory and allergic diseases and inhibition of mast cell activation is a…”
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Atopic dermatitis-like symptoms in hypomagnesaemic hairless rats are prevented and inhibited by systemic or topical SDZ ASM 981 by Neckermann, G., Bavandi, A., Meingassner, J.G.

“…Magnesium deficiency in hairless rats results in a transient erythematous rash within several days, the pathogenetic mechanisms of which are not yet well…”
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Pimecrolimus and tacrolimus differ in their inhibition of lymphocyte activation during the sensitization phase of contact hypersensitivity by Bavandi, A., Fahrngruber, H., Aschauer, H., Hartmann, B., Meingassner, J.G., Kalthoff, F.S.

“…As reported previously, oral administration of the calcineurin inhibitors (CNI) pimecrolimus and tacrolimus resulted in equipotent inhibition of the…”
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Antifungal activity of the allylamine derivative terbinafine in vitro by PETRANYI, G, MEINGASSNER, J. G, MIETH, H

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Immunosuppressive Macrolides of the Type FK 506: A Novel Class of Topical Agents for Treatment of Skin Diseases? by Meingassner, Josef G, Stütz, Anton

“…The immunosuppressive macrolide antibiotics FK 506 and rapamycin were tested for topical activity in experimental allergic contact dermatitis of farm pigs…”
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Activity of terbinafine in experimental fungal infections of laboratory animals by PETRANYI, G, MEINGASSNER, J. G, MIETH, H

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How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches by Biró, T., Ko, M. C., Bromm, B., Wei, E. T., Bigliardi, P., Siebenhaar, F., Hashizume, H., Misery, L., Bergasa, N.V., Kamei, C., Schouenborg, J., Roostermann, D., Szabó, T., Maurer, M., Bigliardi-Qi, M., Meingassner, J. G., Hossen, M. A., Schmelz, M., Steinhoff, M.

“…While the enormous clinical and psychosocial importance of pruritus in many areas of medicine and the detrimental effects of chronic ‘itch’ on the quality of…”
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MDP(Lysyl)GDP, a Nontoxic Muramyl Dipeptide Derivative, Inhibits Cytokine Production by Activated Macrophages and Protects Mice from Phorbol Ester- and Oxazolone-Induced Inflammation by Zunic, Melita, Mudde, Geert C., Meingassner, Josef G., Lam, Charles, Bahr, George M.

“…High levels of pro-inflammatory cytokines and nitric oxide are proposed to orchestrate pathophysiologic mechanism(s) associated with various inflammatory…”
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Synthesis and structure-activity relationships of phenyl-substituted benzylamine antimycotics: a novel benzylbenzylamine antifungal agent for systemic treatment by Nussbaumer, Peter, Dorfstaetter, Gerhard, Grassberger, Maximilian A, Leitner, Ingrid, Meingassner, Josef G, Thirring, Klaus, Stuetz, Anton

“…Derivatives of the benzylamine antimycotics with an extra phenyl ring incorporated in the side chain have been prepared and their antifungal activity…”
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Sympathetic auricular chondritis in rats: a model of autoimmune disease? by Meingassner, J G

“…Following the unilateral implantation of metal ear tags in female Crl:CD(SD)BR-rats, chronic inflammatory lesions were observed in both auricles in 7% and 24%…”
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Pharmacological modulation of endothelial cell-associated adhesion molecule expression: implications for future treatment of dermatological diseases by Foster, C A, Dreyfuss, M, Mandak, B, Meingassner, J G, Naegeli, H U, Nussbaumer, A, Oberer, L, Scheel, G, Swoboda, E M

“…Skin diseases with an inflammatory component, regardless of their etiology, are characterized at some point by the extravasation and subsequent infiltration of…”
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Strain of Trichomonas vaginalis Resistant to Metronidazole and Other 5-Nitroimidazoles by Meingassner, J G, Thurner, J

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Morphological Changes Induced by Naftifine, a New Antifungal Agent, in Trichophyton mentagrophytes by Meingassner, Josef G., Sleytr, Uwe, Petranyi, Gabor

“…The morphological changes in the hyphae of Trichophyton mentagrophytes treated with Naftifine (0.01–0.5 μg/ml) were studied by light and electron microscopy…”
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