Search Results - "Meili, Ruedi"

Three-dimensional quantification of cellular traction forces and mechanosensing of thin substrata by fourier traction force microscopy by del Álamo, Juan C, Meili, Ruedi, Álvarez-González, Begoña, Alonso-Latorre, Baldomero, Bastounis, Effie, Firtel, Richard, Lasheras, Juan C

“…We introduce a novel three-dimensional (3D) traction force microscopy (TFM) method motivated by the recent discovery that cells adhering on plane surfaces…”
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Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis by Funamoto, Satoru, Meili, Ruedi, Lee, Susan, Parry, Lisa, Firtel, Richard A.

“…We have investigated the mechanisms of leading edge formation in chemotaxing Dictyostelium cells. We demonstrate that while phosphatidylinositol 3-kinase…”
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Three-Dimensional Balance of Cortical Tension and Axial Contractility Enables Fast Amoeboid Migration by Álvarez-González, Begoña, Meili, Ruedi, Bastounis, Effie, Firtel, Richard A., Lasheras, Juan C., del Álamo, Juan C.

“…Fast amoeboid migration requires cells to apply mechanical forces on their surroundings via transient adhesions. However, the role these forces play in…”
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Both contractile axial and lateral traction force dynamics drive amoeboid cell motility by Bastounis, Effie, Meili, Ruedi, Álvarez-González, Begoña, Francois, Joshua, del Álamo, Juan C, Firtel, Richard A, Lasheras, Juan C

“…Chemotaxing Dictyostelium discoideum cells adapt their morphology and migration speed in response to intrinsic and extrinsic cues. Using Fourier traction force…”
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G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility by Sasaki, Atsuo T, Janetopoulos, Chris, Lee, Susan, Charest, Pascale G, Takeda, Kosuke, Sundheimer, Lauren W, Meili, Ruedi, Devreotes, Peter N, Firtel, Richard A

“…Phosphoinositide 3-kinase (PI3K)γ and Dictyostelium PI3K are activated via G protein-coupled receptors through binding to the Gβγ subunit and Ras. However, the…”
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Spatio-Temporal Analysis of Eukaryotic Cell Motility by Improved Force Cytometry by Álamo, Juan C. del, Meili, Ruedi, Alonso-Latorre, Baldomero, Rodríguez-Rodríguez, Javier, Aliseda, Alberto, Firtel, Richard A., Lasheras, Juan C.

“…Cell motility plays an essential role in many biological systems, but precise quantitative knowledge of the biophysical processes involved in cell migration is…”
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Myosin II is essential for the spatiotemporal organization of traction forces during cell motility by Meili, Ruedi, Alonso-Latorre, Baldomero, del Alamo, Juan C, Firtel, Richard A, Lasheras, Juan C

“…Amoeboid motility requires spatiotemporal coordination of biochemical pathways regulating force generation and consists of the quasi-periodic repetition of a…”
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Rac regulation of chemotaxis and morphogenesis in Dictyostelium by Park, Kyung Chan, Rivero, Francisco, Meili, Ruedi, Lee, Susan, Apone, Fabio, Firtel, Richard A

“…Chemotaxis requires localized F‐actin polymerization at the site of the plasma membrane closest to the chemoattractant source, a process controlled by…”
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A PTEN-related 5-Phosphatidylinositol Phosphatase Localized in the Golgi by Merlot, Sylvain, Meili, Ruedi, Pagliarini, David J., Maehama, Tomohiko, Dixon, Jack E., Firtel, Richard A.

“…Phosphoinositides play important roles as signaling molecules in different cell compartments by regulating the localization and activity of proteins through…”
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An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway by Moniakis, J, Funamoto, S, Fukuzawa, M, Meisenhelder, J, Araki, T, Abe, T, Meili, R, Hunter, T, Williams, J, Firtel, R A

“…SHK1 is a novel dual-specificity kinase that contains an SH2 domain in its C-terminal region. We demonstrate that SHK1 is required for proper chemotaxis and…”
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Understanding the Mechanics of Neutrophil Migration in Three-Dimensional Extracellular Matrices by Francois, Joshua, Meili, Ruedi, del Alamo, Juan Carlos, Firtel, Richard, Lasheras, Juan C.

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Two-Layer Elastographic 3-D Traction Force Microscopy by Álvarez-González, Begoña, Zhang, Shun, Gómez-González, Manuel, Meili, Ruedi, Firtel, Richard A., Lasheras, Juan C., del Álamo, Juan C.

“…Cellular traction force microscopy (TFM) requires knowledge of the mechanical properties of the substratum where the cells adhere to calculate cell-generated…”
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Mechanics of Adhesion Dependent and Independent Neutrophil Migration in Three-Dimensional Extra-Cellular Matrices by Francois, Joshua, Meili, Ruedi, del Alamo, Juan Carlos, Firtel, Richard A., Lasheras, Juan C.

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Mechanics of Neutrophil Migration in Three-Dimensional Matrices by Francois, Joshua, Meili, Ruedi, del Alamo, Juan Carlos, Firtel, Richard, Lasheras, Juan C.

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Three-Dimensional Balance of Cortical Tension and Axial Contractility Enables Fast Amoeboid Migration by Alvarez-Gonzalez, Begona, Meili, Ruedi, Bastounis, Effie, Firtel, Richard A., Lasheras, Juan C., del Alamo, Juan C.

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The interplay between matrix deformation and the coordination of turning events governs directed neutrophil migration in 3D matrices by François, Joshua, Kandasamy, Adithan, Yeh, Yi-Ting, Schwartz, Amy, Ayala, Cindy, Meili, Ruedi, Chien, Shu, Lasheras, Juan C, Del Álamo, Juan C

“…Neutrophils migrating through extravascular spaces must negotiate narrow matrix pores without losing directional movement. We investigated how chemotaxing…”
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Role of Phosphatidylinositol 3′ Kinase and a Downstream Pleckstrin Homology Domain-Containing Protein in Controlling Chemotaxis in Dictyostelium by Funamoto, Satoru, Milan, Kristina, Meili, Ruedi, Firtel, Richard A.

“…We show that cells lacking two Dictyostelium class I phosphatidylinositol (PI) 3′ kinases (PI3K and pi3k1/2-null cells) or wild-type cells treated with the…”
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Cortical and Cytoskeletal Structural Network regulates the Three-Dimensional Traction Forces Exerted by Migrating Amoeboid Cells by Alvarez-Gonzalez, Begona, Meili, Ruedi, Bastounis, Effie E., del Alamo, Juan C., Firtel, Richard A., Lasheras, Juan C.

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Amoeboid Cells Migrate by Alternating Between Modes with Distinct Adhesion Dynamics and Contractility by Bastounis, Effie, Meili, Ruedi, Álvarez, Begoña, del Álamo, Juan Carlos, Lasheras, Juan, Firtel, Richard

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The SCAR/WAVE complex is necessary for proper regulation of traction stresses during amoeboid motility by Bastounis, Effie, Meili, Ruedi, Alonso-Latorre, Baldomero, del Álamo, Juan C, Lasheras, Juan C, Firtel, Richard A

“…Cell migration requires a tightly regulated, spatiotemporal coordination of underlying biochemical pathways. Crucial to cell migration is SCAR/WAVE-mediated…”
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