Search Results - "Meikle, Peter J"

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders by Meikle, Peter J., Summers, Scott A.

“…Key Points Hypercaloric diets lead to the dysregulation of multiple lipid metabolic pathways, which contributes to the onset and progression of metabolic…”
Get full text

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease by Paul, Sudip, Lancaster, Graeme I., Meikle, Peter J.

“…Plasmalogens are a class of membrane glycerophospholipids with unique properties. They contain a vinyl-ether linked alkyl chain at the sn-1 position of the…”
Get full text

Clinical lipidomics: realizing the potential of lipid profiling by Meikle, Thomas G., Huynh, Kevin, Giles, Corey, Meikle, Peter J.

“…Dysregulation of lipid metabolism plays a major role in the etiology and sequelae of inflammatory disorders, cardiometabolic and neurological diseases, and…”
Get full text

Zebrafish Embryonic Lipidomic Analysis Reveals that the Yolk Cell Is Metabolically Active in Processing Lipid by Fraher, Daniel, Sanigorski, Andrew, Mellett, Natalie A., Meikle, Peter J., Sinclair, Andrew J., Gibert, Yann

“…The role of lipids in providing energy and structural cellular components during vertebrate development is poorly understood. To elucidate these roles further,…”
Get full text

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies by Beyene, Habtamu B, Olshansky, Gavriel, T Smith, Adam Alexander, Giles, Corey, Huynh, Kevin, Cinel, Michelle, Mellett, Natalie A, Cadby, Gemma, Hung, Joseph, Hui, Jennie, Beilby, John, Watts, Gerald F, Shaw, Jonathan E, Moses, Eric K, Magliano, Dianna J, Meikle, Peter J

“…Obesity and related metabolic diseases show clear sex-related differences. The growing burden of these diseases calls for better understanding of the age- and…”
Get full text

Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression by Peng, Kang-Yu, Watt, Matthew J., Rensen, Sander, Greve, Jan Willem, Huynh, Kevin, Jayawardana, Kaushala S., Meikle, Peter J., Meex, Ruth C.R.

“…Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within hepatocytes that can cause severe liver damage and metabolic…”
Get full text

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells by Mukhamedova, Nigora, Hoang, Anh, Dragoljevic, Dragana, Dubrovsky, Larisa, Pushkarsky, Tatiana, Low, Hann, Ditiatkovski, Michael, Fu, Ying, Ohkawa, Ryunosuke, Meikle, Peter J, Horvath, Anelia, Brichacek, Beda, Miller, Yury I, Murphy, Andrew, Bukrinsky, Michael, Sviridov, Dmitri

“…HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and…”
Get full text

Lipidomics: Potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease by MEIKLE, Peter J, WONG, Gerard, BARLOW, Christopher K, KINGWELL, Bronwyn A

“…Lipidomics has developed rapidly over the past decade to the point where clinical application may soon be possible. Developments including high throughput…”
Get full text

Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes by Barber, Melissa N, Risis, Steve, Yang, Christine, Meikle, Peter J, Staples, Margaret, Febbraio, Mark A, Bruce, Clinton R

“…Obesity and type 2 diabetes (T2DM) are associated with increased circulating free fatty acids and triacylglycerols. However, very little is known about…”
Get full text

MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines by Burla, Bo, Arita, Makoto, Arita, Masanori, Bendt, Anne K, Cazenave-Gassiot, Amaury, Dennis, Edward A, Ekroos, Kim, Han, Xianlin, Ikeda, Kazutaka, Liebisch, Gerhard, Lin, Michelle K, Loh, Tze Ping, Meikle, Peter J, Orešič, Matej, Quehenberger, Oswald, Shevchenko, Andrej, Torta, Federico, Wakelam, Michael J O, Wheelock, Craig E, Wenk, Markus R

“…Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in…”
Get full text

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome by Arnold, Matthias, Nho, Kwangsik, Kueider-Paisley, Alexandra, Massaro, Tyler, Huynh, Kevin, Brauner, Barbara, MahmoudianDehkordi, Siamak, Louie, Gregory, Moseley, M. Arthur, Thompson, J. Will, John-Williams, Lisa St, Tenenbaum, Jessica D., Blach, Colette, Chang, Rui, Brinton, Roberta D., Baillie, Rebecca, Han, Xianlin, Trojanowski, John Q., Shaw, Leslie M., Martins, Ralph, Weiner, Michael W., Trushina, Eugenia, Toledo, Jon B., Meikle, Peter J., Bennett, David A., Krumsiek, Jan, Doraiswamy, P. Murali, Saykin, Andrew J., Kaddurah-Daouk, Rima, Kastenmüller, Gabi

“…Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors…”
Get full text

Plasma Lipidomic Profiles Improve on Traditional Risk Factors for the Prediction of Cardiovascular Events in Type 2 Diabetes Mellitus by Alshehry, Zahir H, Mundra, Piyushkumar A, Barlow, Christopher K, Mellett, Natalie A, Wong, Gerard, McConville, Malcolm J, Simes, John, Tonkin, Andrew M, Sullivan, David R, Barnes, Elizabeth H, Nestel, Paul J, Kingwell, Bronwyn A, Marre, Michel, Neal, Bruce, Poulter, Neil R, Rodgers, Anthony, Williams, Bryan, Zoungas, Sophia, Hillis, Graham S, Chalmers, John, Woodward, Mark, Meikle, Peter J

“…BACKGROUND:Clinical lipid measurements do not show the full complexity of the altered lipid metabolism associated with diabetes mellitus or cardiovascular…”
Get full text

Lipidomics Reveals a Tissue-Specific Fingerprint by Pradas, Irene, Huynh, Kevin, Cabré, Rosanna, Ayala, Victòria, Meikle, Peter J, Jové, Mariona, Pamplona, Reinald

“…In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular…”
Get full text

Plasma lipid profiling in a large population-based cohort[S] by Weir, Jacquelyn M., Wong, Gerard, Barlow, Christopher K., Greeve, Melissa A., Kowalczyk, Adam, Almasy, Laura, Comuzzie, Anthony G., Mahaney, Michael C., Jowett, Jeremy B.M., Shaw, Jonathan, Curran, Joanne E., Blangero, John, Meikle, Peter J.

“…We have performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000…”
Get full text

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease by Huynh, Kevin, Lim, Wei Ling Florence, Giles, Corey, Jayawardana, Kaushala S., Salim, Agus, Mellett, Natalie A., Smith, Adam Alexander T., Olshansky, Gavriel, Drew, Brian G., Chatterjee, Pratishtha, Martins, Ian, Laws, Simon M., Bush, Ashley I., Rowe, Christopher C., Villemagne, Victor L., Ames, David, Masters, Colin L., Arnold, Matthias, Nho, Kwangsik, Saykin, Andrew J., Baillie, Rebecca, Han, Xianlin, Kaddurah-Daouk, Rima, Martins, Ralph N., Meikle, Peter J.

“…Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many…”
Get full text

Shared reference materials harmonize lipidomics across MS-based detection platforms and laboratories by Triebl, Alexander, Burla, Bo, Selvalatchmanan, Jayashree, Oh, Jeongah, Tan, Sock Hwee, Chan, Mark Y., Mellet, Natalie A., Meikle, Peter J., Torta, Federico, Wenk, Markus R.

“…Quantitative MS of human plasma lipids is a promising technology for translation into clinical applications. Current MS-based lipidomic methods rely on either…”
Get full text

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites by Braig, David, Nero, Tracy L., Koch, Hans-Georg, Kaiser, Benedict, Wang, Xiaowei, Thiele, Jan R., Morton, Craig J., Zeller, Johannes, Kiefer, Jurij, Potempa, Lawrence A., Mellett, Natalie A., Miles, Luke A., Du, Xiao-Jun, Meikle, Peter J., Huber-Lang, Markus, Stark, G. Björn, Parker, Michael W., Peter, Karlheinz, Eisenhardt, Steffen U.

“…C-reactive protein (CRP) concentrations rise in response to tissue injury or infection. Circulating pentameric CRP (pCRP) localizes to damaged tissue where it…”
Get full text

LDL subclass lipidomics in atherogenic dyslipidemia: effect of statin therapy on bioactive lipids and dense LDL[S] by Chapman, M. John, Orsoni, Alexina, Tan, Ricardo, Mellett, Natalie A., Nguyen, Anh, Robillard, Paul, Giral, Philippe, Thérond, Patrice, Meikle, Peter J.

“…Atherogenic LDL particles are physicochemically and metabolically heterogeneous. Can bioactive lipid cargo differentiate LDL subclasses, and thus potential…”
Get full text

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance by BOON, James, HOY, Andrew J, BRUCE, Clinton R, WATT, Matthew J, STARK, Romana, BROWN, Russell D, MEEX, Ruth C, HENSTRIDGE, Darren C, SCHENK, Simon, MEIKLE, Peter J, HOROWITZ, Jeffrey F, KINGWELL, Bronwyn A

“…Dysregulated lipid metabolism and inflammation are linked to the development of insulin resistance in obesity, and the intracellular accumulation of the…”
Get full text

Fructose stimulated de novo lipogenesis is promoted by inflammation by Todoric, Jelena, Di Caro, Giuseppe, Reibe, Saskia, Henstridge, Darren C., Green, Courtney R., Vrbanac, Alison, Ceteci, Fatih, Conche, Claire, McNulty, Reginald, Shalapour, Shabnam, Taniguchi, Koji, Meikle, Peter J., Watrous, Jeramie D., Moranchel, Rafael, Najhawan, Mahan, Jain, Mohit, Liu, Xiao, Kisseleva, Tatiana, Diaz-Meco, Maria T., Moscat, Jorge, Knight, Rob, Greten, Florian R., Lau, Lester F., Metallo, Christian M., Febbraio, Mark A., Karin, Michael

“…Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA) oxidation, progresses to non-alcoholic steatohepatitis (NASH) on…”
Get full text