Search Results - "Meikle, Murray C."

Short periods of cyclic mechanical strain enhance triple-supplement directed osteogenesis and bone nodule formation by human embryonic stem cells in vitro by Li, Mingming, Li, Xiaobing, Meikle, Murray C, Islam, Intekhab, Cao, Tong

“…Human embryonic stem cells (hESCs) are uniquely endowed with a capacity for both self-renewal and multilineage differentiation. The aim of this investigation…”
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The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt by Meikle, Murray C

“…The first experimental investigation of orthodontic tooth movement was published by Sandstedt in 1904–1905. After 100 years, there is a good understanding of…”
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Cultured human periodontal ligament cells constitutively express multiple osteotropic cytokines and growth factors, several of which are responsive to mechanical deformation by Pinkerton, Mark N., Wescott, David C., Gaffey, Benjamin J., Beggs, Kyle T., Milne, Trudy J., Meikle, Murray C.

“…Background and Objective:  A role for cytokines and growth factors in mediating the cellular and molecular events involved in orthodontic tooth movement is…”
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Alterations in the Synthesis of IL-1β, TNF-α, IL-6, and Their Downstream Targets RANKL and OPG by Mouse Calvarial Osteoblasts In vitro: Inhibition of Bone Resorption by Cyclic Mechanical Strain by García-López, Salvador, Villanueva, Rosina, Meikle, Murray C

“…Mechanical strain is an important determinant of bone mass and architecture, and the aim of this investigation was to further understand the role of the…”
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Differential behaviour and gene expression in 3D cultures of femoral‐ and calvarial‐derived human osteoblasts under a cyclic compressive mechanical load by Itskovich, Yana, Meikle, Murray C, Cannon, Richard D, Farella, Mauro, Coates, Dawn E, Milne, Trudy J

“…The aim of the study was to compare the response of calvarial and femoral osteoblasts cultured in a 3D hydrogel environment to cyclic compressive mechanical…”
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Micro-vibrations at 30 Hz on bone cells cultivated in vitro produce soluble factors for osteoclast inhibition and osteoblast activity by García-López, Salvador, Villanueva, Rosina E., Massó-Rojas, Felipe, Páez-Arenas, Araceli, Meikle, Murray C.

“…•It has been claimed that micro-pulse vibration can accelerate the rate of tooth movement during orthodontic treatment.•The underlying cellular mechanism has…”
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Engineering the periodontal ligament in hyaluronan-gelatin-type I collagen constructs: upregulation of apoptosis and alterations in gene expression by cyclic compressive strain by Saminathan, Aarthi, Sriram, Gopu, Vinoth, Jayasaleen Kumar, Cao, Tong, Meikle, Murray C

“…To engineer constructs of the periodontal ligament (PDL), human PDL cells were incorporated into a matrix of hyaluronan, gelatin, and type I collagen (COLI) in…”
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Re-examination of 'Einige Beitrage zur Theorie der Zahnregulierung' (Some contributions to the theory of the regulation of teeth) published in 1904-1905 by Carl Sandstedt by Bister, Dirk, Meikle, Murray C

“…The original histological investigation that forms the basis of our present understanding of tooth movement was carried out on dogs by the Swedish dentist Carl…”
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Appliance-induced osteopenia of dentoalveolar bone in the rat: effect of reduced bone strains on serum bone markers and the multifunctional hormone leptin by Vinoth, Jayaseelan K., Patel, Kaval J., Lih, Wei-Song, Seow, Yian-San, Cao, Tong, Meikle, Murray C.

“…To understand, in greater detail, the molecular mechanisms regulating the complex relationship between mechanical strain and alveolar bone metabolism during…”
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Induction of osteopenia during experimental tooth movement in the rat: alveolar bone remodelling and the mechanostat theory by Milne, Trudy J., Ichim, Ionut, Patel, Bhavik, McNaughton, Andrew, Meikle, Murray C.

“…Increases in bone strains above a certain threshold have a positive effect on bone mass, whereas reductions in strain magnitude lead to bone loss and…”
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Multiple Extracellular Signals Promote Osteoblast Survival and Apoptosis by Hill, Peter A., Tumber, Anthony, Meikle, Murray C.

“…Abstract Programed cell death (PCD) or apoptosis is a naturally occurring cell suicide pathway induced in a variety of cell types. In many cases, PCD…”
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Re-examination of ‘Einige Beiträge zur Theorie der Zahnregulierung’ (Some contributions to the theory of the regulation of teeth) published in 1904–1905 by Carl Sandstedt by Bister, Dirk, Meikle, Murray C.

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Northcroft Memorial Lecture 2007. A century of progress: advances in orthodontics since the foundation of the British Society for the Study of Orthodontics by Meikle, Murray C

“…The British Orthodontic Society invites outstanding contributors from the field of Orthodontics to give the guest lecture in memory of George Northcroft. In…”
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Altered serum levels of the osteoclast-specific TRACP 5b isoform in Chinese children undergoing orthodontic treatment by Tang, Stephanie J, Meikle, Murray C, MacLaine, James K, Wong, Ricky W K, Rabie, Bakr M

“…Orthodontic tooth movement is dependent upon the ability of mechanical forces to induce remodelling activity within the tooth-supporting alveolar bone. In view…”
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Mechanisms of connective tissue matrix destruction in periodontitis by REYNOLDS, JOHN J., MEIKLE, MURRAY C.

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Guest Editorial: What do prospective randomized clinical trials tell us about the treatment of Class II malocclusions? A personal viewpoint by Meikle, Murray C

“…The prospective randomized clinical trial (RCT) is seen by many to be the ‘gold standard’ for analysing treatment outcome and the only valid source of clinical…”
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The Cellular Actions of Interleukin-11 on Bone Resorption in Vitro by Hill, Peter A, Tumber, Anthony, Papaioannou, Stelios, Meikle, Murray C

“…The pleiotropic cytokine interleukin-11 (IL-11) stimulates osteoclast formation in vitro, but it is not known whether it influences other steps in the…”
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The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts by Hill, P A, Murphy, G, Docherty, A J, Hembry, R M, Millican, T A, Reynolds, J J, Meikle, M C

“…We have compared the effects of a general matrix metalloproteinase (MMP) inhibitor (CT435) with those of a concentration-dependent specific gelatinase…”
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Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines by MEIKLE, M. C, BORD, S, HEMBRY, R. M, COMPSTON, J, CROUCHER, P. I, REYNOLDS, J. J

“…Collagenase production by rodent osteoblasts in response to calciotropic hormones has led to the hypothesis that bone cells play a major role in bone…”
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Human breast‐cancer cells stimulate the fusion, migration and resorptive activity of osteoclasts in bone explants by Tumber, Anthony, Morgan, Hayley M., Meikle, Murray C., Hill, Peter A.

“…A central event in bone resorption is the recruitment of osteoclasts to future resorption sites. Breast‐cancer cells invariably metastasise to the skeleton and…”
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