Search Results - "Meijerman, I."

Keeping pace in the age of innovation: The perspective of Dutch pharmaceutical science students on the position of machine learning training in an undergraduate curriculum by Kidwai, S., Rojas-Velazquez, D., Lopez-Rincon, A., Kraneveld, A.D., Oberski, D.L., Meijerman, I.

“…Over the years, approaches of the pharmaceutical industry to discover and develop drugs have changed rapidly due to new scientific trends. Among others, they…”
Get full text

The role of nuclear receptors in pharmacokinetic drug–drug interactions in oncology by Harmsen, S, Meijerman, I, Beijnen, J.H, Schellens, J.H.M

“…Summary Drug–drug interactions can have a major impact on treatment outcome in cancer patients. These patients are at high risk of such interactions, because…”
Get full text

Effect of Chinese herbs on CYP3A4 activity and expression in vitro by Lau, C., Mooiman, K.D., Maas-Bakker, R.F., Beijnen, J.H., Schellens, J.H.M., Meijerman, I.

“…Traditional Chinese Medicine (TCM) has become more popular among cancer patients in the Western world, who often use Chinese herbs as adjuvant therapy to…”
Get full text

Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor by Harmsen, S, Meijerman, I, Beijnen, J. H, Schellens, J. H. M

“…Purpose Induction of cytochrome P450 (CYP) 3A4, an enzyme that is involved in the biotransformation of more than 50% of all drugs, by xenobiotics is an…”
Get full text

PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors by Harmsen, S., Meijerman, I., Maas-Bakker, R.F., Beijnen, J.H., Schellens, J.H.M.

“…In this paper, we demonstrate that pregnane X receptor (PXR)-mediated induction of P-glycoprotein (PGP) is an important mechanism by which tyrosine kinase…”
Get full text

Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy by Joerger, M., Huitema, A. D. R., Boot, H., Cats, A., Doodeman, V. D., Smits, P. H. M., Vainchtein, L., Rosing, H., Meijerman, I., Zueger, M., Meulendijks, D., Cerny, T. D., Beijnen, J. H., Schellens, J. H. M.

“…Purpose This work was initiated to extend data on the effect of pharmacogenetics and chemotherapy pharmacokinetics (PK) on clinical outcome in patients with…”
Get full text

PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line by Harmsen, Stefan, Meijerman, I., Febus, C. L., Maas-Bakker, R. F., Beijnen, J. H., Schellens, J. H. M.

“…Purpose The development of multidrug resistance (MDR) is one of the major limitations in the treatment of cancer. Induction of P-glycoprotein (Pgp) has been…”
Get full text

Comparison of Two Immortalized Human Cell Lines to Study Nuclear Receptor-Mediated CYP3A4 Induction by HARMSEN, S, KOSTER, A. S, BEIJNEN, J. H, SCHELLENS, J. H. M, MEIJERMAN, I

“…Since CYP3A4 is responsible for the biotransformation of over 50% of all clinically used drugs, induction results in an increased clearance of many…”
Get full text

Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures by Mooiman, K. D., Maas-Bakker, R. F., Rosing, H., Beijnen, J. H., Schellens, J. H. M., Meijerman, I.

“…ABSTRACT Complementary and alternative medicines (CAM) can affect the pharmacokinetics of anticancer drugs by interacting with the metabolizing enzyme…”
Get full text

Effects of cytochrome P450 2C9 polymorphisms on phenprocoumon anticoagulation status by Schalekamp, Tom, Oosterhof, Mirjam, Meegen, Erik, Der Meer, Felix J. M., Conemans, Jean, Hermans, Mirjam, Meijerman, Irma, Boer, Anthonius

“…Objective Our objective was to assess whether there is an association between the presence of allelic variants of the gene for cytochrome P450 (CYP) 2C9 and…”
Get full text

Lethal toxicity of uracil/tegafur in the treatment of sigmoid carcinoma by Bosch, TM, Meijerman, I, Beijnen, JH, van Thiel, SW, Vlasveld, LT

Get full text

Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population by Bosch, T M, Doodeman, V D, Smits, P H M, Meijerman, I, Schellens, J H M, Beijnen, J H

“…A possible explanation for the wide interindividual variability in toxicity and efficacy of drug therapy is variation in genes encoding drug-metabolizing…”
Get full text

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons by Brandon, Esther F.A, Raap, Christiaan D, Meijerman, Irma, Beijnen, Jos H, Schellens, Jan H.M

“…The liver is the predominant organ in which biotransformation of foreign compounds takes place, although other organs may also be involved in drug…”
Get full text

1577PGERMLINE TYMS GENOTYPE IS HIGHLY PREDICTIVE IN PATIENTS WITH ADVANCED COLORECTAL AND GASTROESOPHAGEAL CANCER INDEPENDENT OF FLUOROPYRIMIDINE PHARMACOLOGY: RESULTS FROM TWO PROSPECTIVE TRANSLATIONAL STUDIES by Joerger, M., Huitema, A.D.R., Boot, H., Cats, A., Doodeman, V., Smits, P., Vainchtein, L., Rosing, H., Meijerman, I., Zueger, M., Cerny, T.T., Beijnen, J.H.M., Schellens, J.

“…Abstract Aim: Germline gene polymorphisms may impact clinical outcome in patients with gastrointestinal malignancies, but there are no data on the interaction…”
Get full text

Germline Tyms Genotype is Highly Predictive in Patients with Advanced Colorectal and Gastroesophageal Cancer Independent of Fluoropyrimidine Pharmacology: Results from Two Prospective Translational Studies by Joerger, M., Huitema, A.D.R., Boot, H., Cats, A., Doodeman, V., Smits, P., Vainchtein, L., Rosing, H., Meijerman, I., Zueger, M., Cerny, T.T., Beijnen, J.H.M., Schellens, J.

Get full text

Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines by Brandon, Esther F.A., Bosch, Tessa M., Deenen, Maarten J., Levink, Rianne, van der Wal, Everdina, van Meerveld, Joyce B.M., Bijl, Monique, Beijnen, Jos H., Schellens, Jan H.M., Meijerman, Irma

“…Human cell lines are often used for in vitro biotransformation and transport studies of drugs. In vivo, genetic polymorphisms have been identified in…”
Get full text

MDMA (drug)–drug interactions influence CYP3A4 expression via PXR-mediator by Lobo, I. Antolino, Maas-Bakker, R., Meijerman, I., Meulenbelt, J., Van Den Berg, M., Van Duursen, M.

Get full text

Screening for polymorphisms in the PXR gene in a Dutch population by BOSCH, Tessa M, DEENEN, Maarten, PRUNTEL, Roelof, SMITS, Paul H. M, SCHELLENS, Jan H. M, BEIJNEN, Jos H, MEIJERMAN, Irma

“…Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of over 50% of all drugs currently in use. However, CYP3A4 expression shows a large inter-individual…”
Get full text

In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction by Brandon, Esther F. A, Meijerman, Irma, Klijn, Joyce S, Arend, Dineke den, Sparidans, Rolf W, Lázaro, Louis López, Beijnen, Jos H, Schellens, Jan H. M

“…ET-743 is a marine anti-cancer drug and is currently in phase I trials in which the effect of combination therapies will be investigated. Its dose-limiting…”
Get full text

Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors by Blom, W.Marty, de Bont, Hans J.G.M, Meijerman, Irma, Mulder, Gerard J, Nagelkerke, J.Fred

“…The mechanism by which cycloheximide induces apoptosis in isolated rat hepatocytes was studied. Cycloheximide (1–300 μM) induced apoptosis within 3–4 hr in the…”
Get full text