Search Results - "Meijerink, J P"

Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway by Shen, Y, Park, C S, Suppipat, K, Mistretta, T-A, Puppi, M, Horton, T M, Rabin, K, Gray, N S, Meijerink, J P P, Lacorazza, H D

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a high incidence of relapse in pediatric ALL. Although most T-ALL…”
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CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress by Sarmento, L M, Póvoa, V, Nascimento, R, Real, G, Antunes, I, Martins, L R, Moita, C, Alves, P M, Abecasis, M, Moita, L F, Parkhouse, R M E, Meijerink, J P P, Barata, J T

“…Checkpoint kinase 1 (CHK1) is a key component of the ATR (ataxia telangiectasia-mutated and Rad3-related)-dependent DNA damage response pathway that protect…”
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Myocyte enhancer factor 2C in hematopoiesis and leukemia by Canté-Barrett, K, Pieters, R, Meijerink, J P P

“…MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of…”
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Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia by Watanabe-Smith, K, Tognon, C, Tyner, J W, Meijerink, J P P, Druker, B J, Agarwal, A

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NKL homeobox genes in leukemia by Homminga, I, Pieters, R, Meijerink, J P P

“…NK-like (NKL) homeobox genes code for transcription factors, which can act as key regulators in fundamental cellular processes. NKL genes have been implicated…”
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NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols by Zuurbier, L, Homminga, I, Calvert, V, Winkel, ML te, Buijs-Gladdines, J G C A M, Kooi, C, Smits, W K, Sonneveld, E, Veerman, A J P, Kamps, W A, Horstmann, M, Petricoin, E F, Pieters, R, Meijerink, J P P

“…Aberrant activation of the NOTCH1 pathway by inactivating and activating mutations in NOTCH1 or FBXW7 is a frequent phenomenon in T-cell acute lymphoblastic…”
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Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations by Buitenkamp, T D, Pieters, R, Gallimore, N E, van der Veer, A, Meijerink, J P P, Beverloo, H B, Zimmermann, M, de Haas, V, Richards, S M, Vora, A J, Mitchell, C D, Russell, L J, Schwab, C, Harrison, C J, Moorman, A V, van den Heuvel-Eibrink, M M, den Boer, M L, Zwaan, C M

“…Children with Down’s syndrome (DS) have an increased risk of developing acute lymphoblastic leukemia (ALL) and have a low frequency of established genetic…”
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Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences by van Grotel, M, Meijerink, J P P, van Wering, E R, Langerak, A W, Beverloo, H B, Buijs-Gladdines, J G C A M, Burger, N B, Passier, M, van Lieshout, E M, Kamps, W A, Veerman, A J P, van Noesel, M M, Pieters, R

“…Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is characterized by chromosomal rearrangements possibly enforcing arrest at specific development stages…”
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Cooperative genetic defects in TLX3 rearranged pediatric T-ALL by Van Vlierberghe, P, Homminga, I, Zuurbier, L, Gladdines-Buijs, J, van Wering, E R, Horstmann, M, Beverloo, H B, Pieters, R, Meijerink, J P P

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder, in which multiple genetic abnormalities cooperate in the malignant…”
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A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia by VAN VLIERBERGHE, P, MEIJERINK, J. P. P, LEE, C, FERRANDO, A. A, LOOK, A. T, VAN WERING, E. R, BEVERLOO, H. B, ASTER, J. C, PIETERS, R

“…Over the last decade, genetic characterization of T-cell acute lymphoblastic leukemia (T-ALL) has led to the identification of a variety of chromosomal…”
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Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia by TISSING, W. J. E, MEIJERINK, J. P. P, DEN BOER, M. L, PIETERS, R

“…Glucocorticoids (GC) are probably the most important drugs in the treatment of ALL. Despite the extensive use of GC for many years, little is known about the…”
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Graft-versus-lymphoma effect of donor lymphocyte infusion in indolent lymphomas relapsed after allogeneic stem cell transplantation by MANDIGERS, C. M. P. W, VERDONCK, L. F, MEIJERINK, J. P. P, DEKKER, A. W, SCHATTENBERG, A. V. M. B, RAEMAEKERS, J. M. M

“…Donor lymphocyte infusions (DLI) are used to treat relapsed haematological diseases after allogeneic stem cell transplantation (SCT). We treated seven patients…”
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Monoallelic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia by Van Vlierberghe, P, Beverloo, H B, Buijs-Gladdines, J, van Wering, E R, Horstmann, M, Pieters, R, Meijerink, J P P

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MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia by Canté-Barrett, K, Spijkers-Hagelstein, J A P, Buijs-Gladdines, J G C A M, Uitdehaag, J C M, Smits, W K, van der Zwet, J, Buijsman, R C, Zaman, G J R, Pieters, R, Meijerink, J P P

“…We identified mutations in the IL7Ra gene or in genes encoding the downstream signaling molecules JAK1, JAK3, STAT5B, N-RAS, K-RAS, NF1, AKT and PTEN in 49% of…”
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The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling by Girardi, T, Vereecke, S, Sulima, S O, Khan, Y, Fancello, L, Briggs, J W, Schwab, C, de Beeck, J Op, Verbeeck, J, Royaert, J, Geerdens, E, Vicente, C, Bornschein, S, Harrison, C J, Meijerink, J P, Cools, J, Dinman, J D, Kampen, K R, De Keersmaecker, K

“…Several somatic ribosome defects have recently been discovered in cancer, yet their oncogenic mechanisms remain poorly understood. Here we investigated the…”
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Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia by MEIER, M, DEN BOER, M. L, MEIJERINK, J. P. P, BROEKHUIS, M. J. C, PASSIER, M. M. C. J, VAN WERING, E. R, JANKA-SCHAUB, G. E, PIETERS, R

“…The T-lineage phenotype of childhood acute lymphoblastic leukaemia (ALL) is associated with an increased relapse-risk and in vitro resistance to drugs as…”
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Dynamics of circulating t(14;18)-positive cells during first-line and subsequent lines of treatment in follicular lymphoma by MANDIGERS, C. M. P. W, MEIJERINK, J. P. P, VAN'T VEER, M. B, MENSINK, E. J. B. M, RAEMAEKERS, J. M. M

“…In follicular lymphoma the t(14;18) might be useful as a tumor marker in predicting the quality of the response to treatment. We investigated whether analyzing…”
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Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML) by VAN DEN HEUVEL-EIBRINK, M. M, WIEMER, E. A. C, PRINS, A, MEIJERINK, J. P. P, VOSSEBELD, P. J. M, VAN DER HOLT, B, PIETERS, R, SONNEVELD, P

“…Expression of the multidrug resistance proteins P-glycoprotein, encoded by the MDR1 gene, multidrug resistance-associated protein (MRP1) and the lung…”
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mRNA expression levels of (co)chaperone molecules of the glucocorticoid receptor are not involved in glucocorticoid resistance in pediatric ALL by Tissing, W J E, Meijerink, J P P, den Boer, M L, Brinkhof, B, Pieters, R

“…Resistance to glucocorticoids (GC) is an important adverse risk factor in the treatment of acute lymphoblastic leukemia (ALL). To induce apoptosis, GC bind to…”
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New type of t(14;18) in a non-Hodgkin's lymphoma provides insight in molecular events in early B-cell differentiation by Meijerink, J P, Raemaekers, J M, Mensink, E J

“…In this report a follicular non-Hodgkin's lymphoma (NHL) carrying an unusual t(14;18) is described. This translocation most likely occurred during the VH to…”
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