Search Results - "Meijer Laurent"

Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview by Lindberg, Mattias F, Meijer, Laurent

“…Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-like kinases (CLK1-4) belong to the CMGC group of serine/threonine…”
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Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials by Meijer, Laurent, Raymond, Eric

“…This article reviews the steps that have led us from very fundamental research on the cell division cycle, investigated with the starfish oocyte model, to the…”
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An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs by Koslowski, Svenja, Latapy, Camille, Auvray, Pierrïck, Blondel, Marc, Meijer, Laurent

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common inheritable cause of end stage renal disease and, as of today, only a single moderately…”
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Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases by Sondhi, Sham M., Singh, Nirupma, Kumar, Ashok, Lozach, Olivier, Meijer, Laurent

“…A series of N-(acridin-9-yl)-4-(benzo[ d]imidazol/oxazol-2-yl)benzamides ( 3a– f) has been synthesized by the condensation of 9-aminoacridine derivatives with…”
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Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B by Tahtouh, Tania, Elkins, Jonathan M, Filippakopoulos, Panagis, Soundararajan, Meera, Burgy, Guillaume, Durieu, Emilie, Cochet, Claude, Schmid, Ralf S, Lo, Donald C, Delhommel, Florent, Oberholzer, Anselm E, Pearl, Laurence H, Carreaux, François, Bazureau, Jean-Pierre, Knapp, Stefan, Meijer, Laurent

“…DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer’s…”
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The protein kinase CK1: Inhibition, activation, and possible allosteric modulation by Sunkari, Yashoda Krishna, Meijer, Laurent, Flajolet, Marc

“…Protein kinases play a vital role in biology and deregulation of kinases is implicated in numerous diseases ranging from cancer to neurodegenerative diseases,…”
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Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype by Walter, Anne, Chaikuad, Apirat, Helmer, Renate, Loaëc, Nadège, Preu, Lutz, Ott, Ingo, Knapp, Stefan, Meijer, Laurent, Kunick, Conrad

“…Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other…”
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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor by Brivanlou, Ali H, Sato, Noboru, Meijer, Laurent, Skaltsounis, Leandros, Greengard, Paul

“…Human and mouse embryonic stem cells (HESCs and MESCs, respectively) self-renew indefinitely while maintaining the ability to generate all three germ-layer…”
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(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages by Shrestha, Chandra L., Zhang, Shuzhong, Wisniewski, Benjamin, Häfner, Stephanie, Elie, Jonathan, Meijer, Laurent, Kopp, Benjamin T.

“…Cystic fibrosis (CF) is characterized by chronic bacterial infections and heightened inflammation. Widespread ineffective antibiotic use has led to increased…”
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CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome by Guen, Vincent J., Gamble, Carly, Flajolet, Marc, Unger, Sheila, Thollet, Aurélie, Ferandin, Yoan, Superti-Furga, Andrea, Cohen, Pascale A., Meijer, Laurent, Colas, Pierre

“…Cyclin-dependent kinases (CDKs) regulate a variety of fundamental cellular processes. CDK10 stands out as one of the last orphan CDKs for which no activating…”
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Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing by Debdab, Mansour, Carreaux, François, Renault, Steven, Soundararajan, Meera, Fedorov, Oleg, Filippakopoulos, Panagis, Lozach, Olivier, Babault, Lucie, Tahtouh, Tania, Baratte, Blandine, Ogawa, Yasushi, Hagiwara, Masatoshi, Eisenreich, Andreas, Rauch, Ursula, Knapp, Stefan, Meijer, Laurent, Bazureau, Jean-Pierre

“…We here report on the synthesis, optimization, and biological characterization of leucettines, a family of kinase inhibitors derived from the marine sponge…”
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Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design by Meine, Rosanna, Becker, Walter, Falke, Hannes, Preu, Lutz, Loaëc, Nadège, Meijer, Laurent, Kunick, Conrad

“…Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a potential drug target because of its role in the development of Down syndrome and…”
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Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia by Carey-Smith, Shannon L, Simad, Maryam H, Panchal, Kunjal, Aya-Bonilla, Carlos, Smolders, Hannah, Lin, Sang, Armitage, Jesse D, Nguyen, Vivien T, Bentley, Kathryn, Ford, Jette, Singh, Sajla, Oommen, Joyce, Laurent, Anouchka P, Mercher, Thomas, Crispino, John D, Montgomery, Andrew P, Kassiou, Michael, Besson, Thierry, Deau, Emmanuel, Meijer, Laurent, Cheung, Laurence C, Kotecha, Rishi S, Malinge, Sébastien

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Synthesis, Protein Kinase Inhibitory Potencies, and in Vitro Antiproliferative Activities of Meridianin Derivatives by Giraud, Francis, Alves, Georges, Debiton, Eric, Nauton, Lionel, Théry, Vincent, Durieu, Emilie, Ferandin, Yoan, Lozach, Olivier, Meijer, Laurent, Anizon, Fabrice, Pereira, Elisabeth, Moreau, Pascale

“…The synthesis of new meridianin derivatives is described. The indolic ring system was substituted at the C-4 to C-7 positions either by a bromine atom or by…”
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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A by Nguyen, Thu Lan, Duchon, Arnaud, Manousopoulou, Antigoni, Loaëc, Nadège, Villiers, Benoît, Pani, Guillaume, Karatas, Meltem, Mechling, Anna E, Harsan, Laura-Adela, Limanton, Emmanuelle, Bazureau, Jean-Pierre, Carreaux, François, Garbis, Spiros D, Meijer, Laurent, Herault, Yann

“…Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here…”
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TRPC6 channel translocation into phagosomal membrane augments phagosomal function by Riazanski, Vladimir, Gabdoulkhakova, Aida G., Boynton, Lin S., Eguchi, Raphael R., Deriy, Ludmila V., Hogarth, D. Kyle, Loaëc, Nadège, Oumata, Nassima, Galons, Hervé, Brown, Mary E., Shevchenko, Pavel, Gallan, Alexander J., Yoo, Sang Gune, Naren, Anjaparavanda P., Villereal, Mitchel L., Beacham, Daniel W., Bindokas, Vytautas P., Birnbaumer, Lutz, Meijer, Laurent, Nelson, Deborah J.

“…Defects in the innate immune system in the lung with attendant bacterial infections contribute to lung tissue damage, respiratory insufficiency, and ultimately…”
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Synthesis, Resolution, and Biological Evaluation of Atropisomeric (aR)- and (aS)‑16-Methyllamellarins N: Unique Effects of the Axial Chirality on the Selectivity of Protein Kinases Inhibition by Yoshida, Kenyu, Itoyama, Ryosuke, Yamahira, Masashi, Tanaka, Junji, Loaëc, Nadège, Lozach, Olivier, Durieu, Emilie, Fukuda, Tsutomu, Ishibashi, Fumito, Meijer, Laurent, Iwao, Masatomo

“…The total synthesis of the optically active (aR)- and (aS)-16-methyllamellarins N (3a and 3b) was achieved via resolution on HPLC chiral stationary phase. The…”
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Indirubin Derivative 6BIO Suppresses Metastasis by BRAIG, Simone, KRESSIRER, Christine A, LIEBL, Johanna, BISCHOFF, Fabian, ZAHLER, Stefan, MEIJER, Laurent, VOLLMAR, Angelika M

“…While metastasis is the chief cause of cancer mortality, there nonetheless remains a lack of antimetastatic therapies that are clinically available. In this…”
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Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models by Menn, Bénédicte, Bach, Stéphane, Blevins, Teri L, Campbell, Mark, Meijer, Laurent, Timsit, Serge

“…Although quite challenging, neuroprotective therapies in ischemic stroke remain an interesting strategy to counter mechanisms of ischemic injury and reduce…”
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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases by Loaëc, Nadège, Attanasio, Eletta, Villiers, Benoît, Durieu, Emilie, Tahtouh, Tania, Cam, Morgane, Davis, Rohan A, Alencar, Aline, Roué, Mélanie, Bourguet-Kondracki, Marie-Lise, Proksch, Peter, Limanton, Emmanuelle, Guiheneuf, Solène, Carreaux, François, Bazureau, Jean-Pierre, Klautau, Michelle, Meijer, Laurent

“…A large diversity of 2-aminoimidazolone alkaloids is produced by various marine invertebrates, especially by the marine Calcareous sponges and . The phylogeny…”
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