Search Results - "Meijer, Femke A"

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR by Stevers, Loes M., Lam, Chan V., Leysen, Seppe F. R., Meijer, Femke A., van Scheppingen, Daphne S., de Vries, Rens M. J. M., Carlile, Graeme W., Milroy, Lech G., Thomas, David Y., Brunsveld, Luc, Ottmann, Christian

“…Cystic fibrosis is a fatal genetic disease, most frequently caused by the retention of the CFTR (cystic fibrosis transmembrane conductance regulator) mutant…”
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Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization by Scheepstra, Marcel, Andrei, Sebastian A, de Vries, Rens M. J. M, Meijer, Femke A, Ma, Jian-Nong, Burstein, Ethan S, Olsson, Roger, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc

“…Retinoid X receptors (RXRs) play key roles in many physiological processes in both the periphery and central nervous system. In addition, RXRs form…”
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Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand by Meijer, Femke A, Oerlemans, Guido J.M, Brunsveld, Luc

“…The RORγt nuclear receptor (NR) is of critical importance for the differentiation and proliferation of T helper 17 (Th17) cells and their production of the…”
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Allosteric small molecule modulators of nuclear receptors by Meijer, Femke A., Leijten-van de Gevel, Iris A., de Vries, Rens M.J.M., Brunsveld, Luc

“…Nuclear Receptors (NRs) are multi-domain proteins, whose natural regulation occurs via ligands for a classical, orthosteric, binding pocket and via intra- and…”
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Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt by de Vries, Rens M. J. M., Meijer, Femke A., Doveston, Richard G., Leijten-van de Gevel, Iris A., Brunsveld, Luc

“…Cooperative ligand binding is an important phenomenon in biological systems where ligand binding influences the binding of another ligand at an alternative…”
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Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists by Meijer, Femke A, Doveston, Richard G, de Vries, Rens M.J.M, Vos, Gaël M, Vos, Alex A.A, Leysen, Seppe, Scheepstra, Marcel, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc

“…Retinoic acid receptor-related orphan receptor γt (RORγt) is a nuclear receptor associated with the pathogenesis of autoimmune diseases. Allosteric inhibition…”
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Structure–Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt by Meijer, Femke A, Saris, Annet O.W.M, Doveston, Richard G, Oerlemans, Guido J.M, de Vries, Rens M.J.M, Somsen, Bente A, Unger, Anke, Klebl, Bert, Ottmann, Christian, Cossar, Peter J, Brunsveld, Luc

“…The inhibition of the nuclear receptor retinoic-acid-receptor-related orphan receptor γt (RORγt) is a promising strategy in the treatment of autoimmune…”
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Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD by Prokop, Jeremy W, Yeo, Nan Cher, Ottmann, Christian, Chhetri, Surya B, Florus, Kacie L, Ross, Emily J, Sosonkina, Nadiya, Link, Brian A, Freedman, Barry I, Coppola, Candice J, McDermott-Roe, Chris, Leysen, Seppe, Milroy, Lech-Gustav, Meijer, Femke A, Geurts, Aron M, Rauscher, 3rd, Frank J, Ramaker, Ryne, Flister, Michael J, Jacob, Howard J, Mendenhall, Eric M, Lazar, Jozef

“…Interpreting genetic variants is one of the greatest challenges impeding analysis of rapidly increasing volumes of genomic data from patients. For example, is…”
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Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes by Andrei, Sebastian A, Meijer, Femke A, Neves, João Filipe, Brunsveld, Luc, Landrieu, Isabelle, Ottmann, Christian, Milroy, Lech-Gustav

“…Current molecular hypotheses have not yet delivered marketable treatments for Alzheimer’s disease (AD), arguably due to a lack of understanding of AD biology…”
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Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist by Vries, Rens M. J. M., Doveston, Richard G., Meijer, Femke A., Brunsveld, Luc

“…The demand for allosteric targeting of nuclear receptors is high, but examples are limited, and structural information is scarce. The retinoic acid‐related…”
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Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site by Meijer, Femke A, van den Oetelaar, Maxime C. M, Doveston, Richard G, Sampers, Ella N. R, Brunsveld, Luc

“…The nuclear receptor RORγt is a key positive regulator in the differentiation and proliferation of T helper 17 (Th17) cells and the production of…”
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