Search Results - "Meiffren, Grégory"

Autophagy induction by the pathogen receptor CD46 by Joubert, Pierre-Emmanuel, Meiffren, Grégory, Grégoire, Isabel Pombo, Pontini, Guillemette, Richetta, Clémence, Flacher, Monique, Azocar, Olga, Vidalain, Pierre-Olivier, Vidal, Marc, Lotteau, Vincent, Codogno, Patrice, Rabourdin-Combe, Chantal, Faure, Mathias

“…Autophagy is a highly regulated self-degradative mechanism required at a basal level for intracellular clearance and recycling of cytoplasmic contents. Upon…”
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Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis by Astier, Anne L, Meiffren, Gregory, Freeman, Samuel, Hafler, David A

“…Loss of Treg function appears to be a critical factor in the pathogenesis of human autoimmune diseases. Attention has focused on defects of CD4(+)CD25(high)…”
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Ultra‐rapid BioChaperone Lispro improves postprandial blood glucose excursions vs insulin lispro in a 14‐day crossover treatment study in people with type 1 diabetes by Andersen, Grit, Meiffren, Grégory, Lamers, Daniela, DeVries, J. Hans, Ranson, Aymeric, Seroussi, Cyril, Alluis, Bertrand, Gaudier, Martin, Soula, Olivier, Heise, Tim

“…Aim To investigate the safety and efficacy of BioChaperone Lispo (BCLIS), an ultra‐rapid formulation of insulin lispro (LIS) in people with type 1 diabetes…”
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ADO09, a co‐formulation of the amylin analogue pramlintide and the insulin analogue A21G, lowers postprandial blood glucose versus insulin lispro in type 1 diabetes by Andersen, Grit, Meiffren, Grégory, Famulla, Susanne, Heise, Tim, Ranson, Aymeric, Seroussi, Cyril, Eloy, Rosy, Gaudier, Martin, Charvet, Richard, Chan, You‐Ping, Soula, Olivier, DeVries, J. Hans

“…Aim To compare the safety, pharmacokinetics and pharmacodynamics of ADO09 with insulin lispro (Lispro) and separate subcutaneous injections of human insulin…”
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BioChaperone Lispro versus faster aspart and insulin aspart in patients with type 1 diabetes using continuous subcutaneous insulin infusion: A randomized euglycemic clamp study by Heise, Tim, Meiffren, Grégory, Alluis, Bertrand, Seroussi, Cyril, Ranson, Aymeric, Arrubla, Jorge, Correia, José, Gaudier, Martin, Soula, Olivier, Soula, Rémi, DeVries, J. Hans, Klein, Oliver, Bode, Bruce

“…We investigated the pharmacodynamics (PD) and pharmacokinetics (PK) of BioChaperone insulin Lispro (BCLIS), faster insulin aspart (FIA) and insulin aspart…”
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A co‐formulation of pramlintide and insulin A21G (ADO09) improves postprandial glucose and short‐term control of mean glucose, time in range, and body weight versus insulin aspart in adults with type 1 diabetes by Andersen, Grit, Eloy, Rosy, Famulla, Susanne, Heise, Tim, Meiffren, Grégory, Seroussi, Cyril, Gaudier, Martin, Mégret, Claire, Chan, You‐Ping, Soula, Olivier, Riddle, Matthew

“…Aim Pramlintide improves postprandial glucose but requires additional injections. We investigated the pharmacokinetics/pharmacodynamics, efficacy and safety of…”
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Better glycaemic control with BioChaperone glargine lispro co‐formulation than with insulin lispro Mix25 or separate glargine and lispro administrations after a test meal in people with type 2 diabetes by Meiffren, Grégory, Herbrand, Theresa, Anastassiadis, Ernestos, Klein, Oliver, DeVries, J. Hans, Heise, Tim, Alluis, Bertrand, Mégret, Claire, Gaudier, Martin, Soula, Olivier, Plum‐Mörschel, Leona

“…Because of its physico‐chemical properties, insulin glargine is usually not mixable with rapid insulins. BioChaperone BC147 is a polyanionic amphiphilic…”
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Pathogen recognition by the cell surface receptor CD46 induces autophagy by Meiffren, Grégory, Joubert, Pierre-Emmanuel, Grégoire, Isabel Pombo, Codogno, Patrice, Rabourdin-Combe, Chantal, Faure, Mathias

“…Autophagy is a degradative mechanism involved in cell protection against invading pathogens. Although the autophagic process is well characterized, the…”
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Cutting Edge: Abortive Proliferation of CD46-Induced Tr1-Like Cells due to a Defective Akt/Survivin Signaling Pathway by Meiffren, Gregory, Flacher, Monique, Azocar, Olga, Rabourdin-Combe, Chantal, Faure, Mathias

“…T regulatory cell 1 (Tr1) are low proliferating peripherally induced suppressive T cells. Engaging CD3 and CD46 on human CD4+ T cells induces a Tr1-like…”
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Autophagy and pathogens: «Bon appétit Messieurs! by Joubert, Pierre-Emmanuel, Pombo Grégoire, Isabel, Meiffren, Grégory, Rabourdin-Combe, Chantal, Faure, Mathias

“…Autophagy is a highly conserved, self-degradative pathway for clearance and recycling of cytoplasmic contents. This ubiquitous cell intrinsic process can be…”
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Cover Image by Andersen, Grit, Eloy, Rosy, Famulla, Susanne, Heise, Tim, Meiffren, Grégory, Seroussi, Cyril, Gaudier, Martin, Mégret, Claire, Chan, You‐Ping, Soula, Olivier, Riddle, Matthew

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197-OR: ADO09, a Coformulation of Insulin A21G and Pramlintide (Pram), Improves Blood Glucose Control and Reduces Body Weight in Subjects with T1D by MEIFFREN, GRÉGORY, ANDERSEN, GRIT, ELOY, ROSY, MÉGRET, CLAIRE, FAMULLA, SUSANNE, SEROUSSI, CYRIL, CHAN, YOU-PING, GAUDIER, MARTIN, SOULA, OLIVIER, DEVRIES, J. HANS, HEISE, TIM

“…ADO09 is a co-formulation of Pram and insulin A21G developed to deliver the positive effects of Pram without additional injections. This double-blind…”
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Pooled Analysis of Clinical Trials Investigating the Pharmacokinetics (PK) of Ultra-rapid Insulin BioChaperone Lispro (BCLIS) vs. Lispro (LIS) in Subjects with Type 1 (T1D) and Type 2 (T2D) Diabetes by HEISE, TIM, RANSON, AYMERIC, GAUDIER, MARTIN, SOULA, OLIVIER, ALLUIS, BERTRAND, ZIJLSTRA, ERIC, GLEZER, STANISLAV, MEIFFREN, GRÉGORY

“…BCLIS is an ultra-rapid insulin lispro formulation designed to accelerate the time-action profile vs. conventional short-acting insulin analogs. PK…”
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2008-P: BioChaperone Glucagon Exenatide (BC Glu Exe), a Stable Combination of Glucagon (Glu) and Exenatide (Exe) Achieved Larger Body Weight (BW) Loss than Exe Alone in DIO Mice by GAUDIER, MARTIN, HAKIM, SANA, MÉGRET, CLAIRE, BEZAGU, MARINE, FRANCOIS-HEUDE, MARC, REGAIRAZ, ANNE, MEIFFREN, GRÉGORY, SOULA, RÉMI, SOULA, OLIVIER

“…Combination of excessive food intake and lack of physical activity is associated with an increased risk of obesity and associated morbidity. GLP-1 Receptor…”
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112-LB: ADO09, a Coformulation of Pramlintide (PRAM) and Insulin A21G, Improves Postprandial Glucose vs. Novolog in Type 1 Diabetes (T1D) by MEIFFREN, GRÉGORY, ANDERSEN, GRIT, ELOY, ROSY, SEROUSSI, CYRIL, MÉGRET, CLAIRE, FAMULLA, SUSANNE, CHAN, YOU-PING, GAUDIER, MARTIN, SOULA, OLIVIER, DEVRIES, J. HANS, HEISE, TIM

“…ADO09 is a co-formulation of PRAM and insulin A21G developed to leverage the beneficial effects of PRAM on post-prandial glucose without additional injections…”
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Cover Image, Volume 23, Issue 4 by Andersen, Grit, Meiffren, Grégory, Famulla, Susanne, Heise, Tim, Ranson, Aymeric, Seroussi, Cyril, Eloy, Rosy, Gaudier, Martin, Charvet, Richard, Chan, You‐Ping, Soula, Olivier, DeVries, J. Hans

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BioChaperone Technology Enables the Development of Pramlintide-Prandial Insulin Combinations by MEIFFREN, GRÉGORY, GEISSLER, ALEXANDRE, MEYER, YVES, RANSON, AYMERIC, FORTIER, CHARLES, SOULA, OLIVIER, SOULA, RÉMI, ALLUIS, BERTRAND, CHARVET, RICHARD

“…Pramlintide (Symlin®) is currently used on top of mealtime insulin therapy by T1D or T2D patients to achieve a better control of post-prandial glucose…”
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150-OR: BioChaperone Pramlintide Insulin (BCPramIns), a New Co-Formulation of Pramlintide (PRAM) and Human Insulin (INS), Improves Postprandial Blood Glucose (BG) vs. Both Separate Injections of PRAM+INS and Insulin Lispro (LIS) in Subjects with T1D by MEIFFREN, GRÉGORY, SEROUSSI, CYRIL, RANSON, AYMERIC, CHARVET, RICHARD, GAUDIER, MARTIN, ANDERSEN, GRIT, ZIJLSTRA, ERIC, DEVRIES, J. HANS, HEISE, TIM, SOULA, RÉMI, SOULA, OLIVIER

“…BCPramIns is developed to leverage the beneficial effects of PRAM on post-prandial BG control in a convenient co-formulation with INS. This double-blind,…”
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Better Postprandial Glucose (PPG) Control with BioChaperone Combo (BC Combo) than with Lispro Mix25 (LMx) or Separate Glargine and Lispro (G+L) Administrations in Subjects with Type 2 Diabetes (T2DM) by HEISE, TIM, MOERSCHEL, LEONA PLUM, MÉGRET, CLAIRE, HERBRAND, THERESA, VACHER, VÉRONIQUE, ANASTASSIADIS, ERNESTOS, KLEIN, OLIVER, GAUDIER, MARTIN, SOULA, OLIVIER, GLEZER, STANISLAV, ALLUIS, BERTRAND, MEIFFREN, GRÉGORY

“…BC Combo is a co-formulation of prandial insulin lispro (25%) and basal insulin glargine (75%) with a rapid “prandial“ insulin component and prolonged flat…”
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The Ultra-rapid Insulin (URI) BioChaperone Lispro (BCLIS) Shows Favorable Pharmacodynamics (PD) and Pharmacokinetics (PK) vs. Faster Aspart (FIA) and Insulin Aspart (ASP) in Insulin Pumps (CSII) by BODE, BRUCE W., KLEIN, OLIVER, SEROUSSI, CYRIL, RANSON, AYMERIC, ARRUBLA, JORGE, CORREIA, JOSÉ, GAUDIER, MARTIN, SOULA, OLIVIER, SOULA, RÉMI, ALLUIS, BERTRAND, MEIFFREN, GRÉGORY, GLEZER, STANISLAV, HEISE, TIM

“…This double-blind randomized crossover trial is the first to compare the PD and PK properties of two URIs (BCLIS and FIA) and of a conventional analog (ASP)…”
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