Search Results - "Meier, Irene"

White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease by Lee, Seonjoo, Zimmerman, Molly E, Narkhede, Atul, Nasrabady, Sara E, Tosto, Giuseppe, Meier, Irene B, Benzinger, Tammie L S, Marcus, Daniel S, Fagan, Anne M, Fox, Nick C, Cairns, Nigel J, Holtzman, David M, Buckles, Virginia, Ghetti, Bernardino, McDade, Eric, Martins, Ralph N, Saykin, Andrew J, Masters, Colin L, Ringman, John M, Fӧrster, Stefan, Schofield, Peter R, Sperling, Reisa A, Johnson, Keith A, Chhatwal, Jasmeer P, Salloway, Stephen, Correia, Stephen, Jack, Jr, Clifford R, Weiner, Michael, Bateman, Randall J, Morris, John C, Mayeux, Richard, Brickman, Adam M

“…White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer's disease (AD)…”
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Reconsidering harbingers of dementia: progression of parietal lobe white matter hyperintensities predicts Alzheimer's disease incidence by Brickman, Adam M, Zahodne, Laura B, Guzman, Vanessa A, Narkhede, Atul, Meier, Irene B, Griffith, Erica Y, Provenzano, Frank A, Schupf, Nicole, Manly, Jennifer J, Stern, Yaakov, Luchsinger, José A, Mayeux, Richard

“…Abstract Accumulating evidence implicates small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMH) on T2-weighted magnetic…”
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Automated detection of cerebral microbleeds on T2-weighted MRI by Chesebro, Anthony G., Amarante, Erica, Lao, Patrick J., Meier, Irene B., Mayeux, Richard, Brickman, Adam M.

“…Cerebral microbleeds, observed as small, spherical hypointense regions on gradient echo (GRE) or susceptibility weighted (SWI) magnetic resonance imaging (MRI)…”
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White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease? by Provenzano, Frank A, Muraskin, Jordan, Tosto, Giuseppe, Narkhede, Atul, Wasserman, Ben T, Griffith, Erica Y, Guzman, Vanessa A, Meier, Irene B, Zimmerman, Molly E, Brickman, Adam M

“…Current hypothetical models emphasize the importance of β-amyloid in Alzheimer disease (AD) pathogenesis, although amyloid alone is not sufficient to account…”
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Testing the white matter retrogenesis hypothesis of cognitive aging by Brickman, Adam M, Meier, Irene B, Korgaonkar, Mayuresh S, Provenzano, Frank A, Grieve, Stuart M, Siedlecki, Karen L, Wasserman, Ben T, Williams, Leanne M, Zimmerman, Molly E

“…Abstract The retrogenesis hypothesis postulates that late-myelinated white matter fibers are most vulnerable to age- and disease-related degeneration, which in…”
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White matter hyperintensities mediate the association of nocturnal blood pressure with cognition by Chesebro, Anthony G., Melgarejo, Jesus D., Leendertz, Reinier, Igwe, Kay C., Lao, Patrick J., Laing, Krystal K., Rizvi, Batool, Budge, Mariana, Meier, Irene B., Calmon, Gustavo, Lee, Joseph H., Maestre, Gladys E., Brickman, Adam M.

“…OBJECTIVETo test the hypotheses that hypertension and nocturnal blood pressure are related to white matter hyperintensity (WMH) volume, an MRI marker of small…”
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Using a Digital Neuro Signature to measure longitudinal individual-level change in Alzheimer’s disease: the Altoida large cohort study by Meier, Irene B., Buegler, Max, Harms, Robbert, Seixas, Azizi, Çöltekin, Arzu, Tarnanas, Ioannis

“…Conventional neuropsychological assessments for Alzheimer’s disease are burdensome and inaccurate at detecting mild cognitive impairment and predicting…”
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Increased Levels of Circulating Angiogenic Cells and Signaling Proteins in Older Adults With Cerebral Small Vessel Disease by Kapoor, Arunima, Gaubert, Aimée, Marshall, Anisa, Meier, Irene B, Yew, Belinda, Ho, Jean K, Blanken, Anna E, Dutt, Shubir, Sible, Isabel J, Li, Yanrong, Jang, Jung Yun, Brickman, Adam M, Rodgers, Kathleen, Nation, Daniel A

“…Cerebral small vessel disease (SVD) is associated with increased risk of stroke and dementia. Progressive damage to the cerebral microvasculature may also…”
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Author Response: White Matter Hyperintensities Mediate the Association of Nocturnal Blood Pressure With Cognition by Chesebro, Anthony G., Melgarejo, Jesus D., Leendertz, Reinier, Igwe, Kay C., Lao, Patrick J., Laing, Krystal K., Rizvi, Batool, Budge, Mariana, Meier, Irene B., Calmon, Gustavo, Lee, Joseph H., Maestre, Gladys, Brickman, Adam M.

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The ModRey: An Episodic Memory Test for Nonclinical and Preclinical Populations by Hale, Christiane, Last, Briana S., Meier, Irene B., Yeung, Lok-Kin, Budge, Mariana, Sloan, Richard P., Small, Scott A., Brickman, Adam M.

“…List learning tests are used in practice for diagnosis and in research to characterize episodic memory, but often suffer from ceiling effects in unimpaired…”
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Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults by Gu, Yian, Gutierrez, Jose, Meier, Irene B, Guzman, Vanessa A, Manly, Jennifer J, Schupf, Nicole, Brickman, Adam M, Mayeux, Richard

“…OBJECTIVEThis investigation aimed at examining whether circulating inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL6), and alpha…”
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Remote monitoring technologies in Alzheimer's disease: design of the RADAR-AD study by Muurling, Marijn, de Boer, Casper, Kozak, Rouba, Religa, Dorota, Koychev, Ivan, Verheij, Herman, Nies, Vera J M, Duyndam, Alexander, Sood, Meemansa, Fröhlich, Holger, Hannesdottir, Kristin, Erdemli, Gul, Lucivero, Federica, Lancaster, Claire, Hinds, Chris, Stravopoulos, Thanos G, Nikolopoulos, Spiros, Kompatsiaris, Ioannis, Manyakov, Nikolay V, Owens, Andrew P, Narayan, Vaibhav A, Aarsland, Dag, Visser, Pieter Jelle

“…Functional decline in Alzheimer's disease (AD) is typically measured using single-time point subjective rating scales, which rely on direct observation or…”
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Cerebral microbleeds in a multiethnic elderly community: Demographic and clinical correlates by Wiegman, Anne F, Meier, Irene B, Schupf, Nicole, Manly, Jennifer J, Guzman, Vanessa A, Narkhede, Atul, Stern, Yaakov, Martinez-Ramirez, Sergi, Viswanathan, Anand, Luchsinger, José A, Greenberg, Steven M, Mayeux, Richard, Brickman, Adam M

“…Abstract Background Microbleeds, small perivascular collections of hemosiderin manifested radiologically as hypointensities on gradient-echo magnetic resonance…”
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Digital biomarkers and sex impacts in Alzheimer’s disease management — potential utility for innovative 3P medicine approach by Harms, Robbert L., Ferrari, Alberto, Meier, Irene B., Martinkova, Julie, Santus, Enrico, Marino, Nicola, Cirillo, Davide, Mellino, Simona, Catuara Solarz, Silvina, Tarnanas, Ioannis, Szoeke, Cassandra, Hort, Jakub, Valencia, Alfonso, Ferretti, Maria Teresa, Seixas, Azizi, Santuccione Chadha, Antonella

“…Digital biomarkers are defined as objective, quantifiable physiological and behavioral data that are collected and measured by means of digital devices. Their…”
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Lobar microbleeds are associated with a decline in executive functioning in older adults by Meier, Irene B, Gu, Yian, Guzaman, Vanessa A, Wiegman, Anne F, Schupf, Nicole, Manly, Jennifer J, Luchsinger, José A, Viswanathan, Anand, Martinez-Ramirez, Sergi, Greenberg, Steven M, Mayeux, Richard, Brickman, Adam M

“…Normal aging is associated with a decline in cognitive abilities, particularly in the domains of psychomotor speed and executive functioning. However, 'aging,'…”
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Is the Alzheimer’s disease cortical thickness signature a biological marker for memory? by Busovaca, Edgar, Zimmerman, Molly E., Meier, Irene B., Griffith, Erica Y., Grieve, Stuart M., Korgaonkar, Mayuresh S., Williams, Leanne M., Brickman, Adam M.

“…Recent work suggests that analysis of the cortical thickness in key brain regions can be used to identify individuals at greatest risk for development of…”
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Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease by Quevenco, Frances C, Preti, Maria G, van Bergen, Jiri M G, Hua, Jun, Wyss, Michael, Li, Xu, Schreiner, Simon J, Steininger, Stefanie C, Meyer, Rafael, Meier, Irene B, Brickman, Adam M, Leh, Sandra E, Gietl, Anton F, Buck, Alfred, Nitsch, Roger M, Pruessmann, Klaas P, van Zijl, Peter C M, Hock, Christoph, Van De Ville, Dimitri, Unschuld, Paul G

“…The incidence of Alzheimer's disease (AD) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (Aβ), hyperphosphorylated tau,…”
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White matter predictors of cognitive functioning in older adults by Meier, Irene B, Manly, Jennifer J, Provenzano, Frank A, Louie, Karmen S, Wasserman, Ben T, Griffith, Erica Y, Hector, Josina T, Allocco, Elizabeth, Brickman, Adam M

“…Few studies have applied multiple imaging modalities to examine cognitive correlates of white matter. We examined the utility of T2-weighted magnetic resonance…”
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Cerebrovascular Disease and Neurodegeneration in Alzheimer's Disease with and without a Strong Family History: A Pilot Magnetic Resonance Imaging Study in Dominican Republic by Piriz, Angel, Reyes, Dolly, Narkhede, Atul, Guzman, Vanessa A, Viqar, Fawad, Meier, Irene B, Budge, Mariana, Mena, Pedro, Dashnaw, Stephen, Lee, Joseph, Reitz, Christiane, Gutierrez, Jose, Campos, Luis, Medrano, Martin, Lantigua, Rafael, Mayeux, Richard, Brickman, Adam M

“…The incidence and prevalence of Alzheimer's disease (AD) dementia are higher among Caribbean Hispanics than among non-Hispanic Whites. The causes of this…”
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The impact of SARS‐CoV‐2 in dementia across Latin America: A call for an urgent regional plan and coordinated response by Ibanez, Agustin, Santamaria‐Garcia, Hernando, Guerrero Barragan, Alejandra, Kornhuber, Alexander, Ton, Alyne Mendonca Marques, Slachevsky, Andrea, Teixeira, Antonio Lucio, Mar Meza, Beatriz Marcela, Serrano, Cecilia M., Cano, Carlos, Arias Gonzalez, Carolina, Gonzalez‐Billault, Christian, Butler, Christopher, Bustin, Julian, Duran‐Aniotz, Claudia, Acosta, Daisy, Matallana, Diana L., Acosta‐Alvear, Diego, Trépel, Dominic, Resende, Elisa De Paula França, Oliveira, Fabricio Ferreira, Ibanez, Francisco, De Felice, Fernanda G., Navarrete, Gorka, Tarnanas, Ioannis, Meier, Irene B., Smid, Jerusa, Llibre‐Guerra, Jorge, Llibre‐Rodriguez, Juan J., Fajersztajn, Laís, Takada, Leonel Tadao, Duque, Lissette, Okada de Oliveira, Maira, Bicalho, Maria Aparecida Camargos, Behrens, María Isabel, Pintado‐Caipa, Maritza, Parra, Mario, Wilson, Maxwell Z., De La Cruz Puebla, Myriam, Custodio, Nilton, Santibanez, Rodrigo, Serafim, Rodrigo Bernardo, Tavares, Ronnielly Melo, Piña Escudero, Stefanie Danielle, Leon Rodriguez, Tomas, Dawson, Walter, Miller, Bruce L., Kosik, Kenneth S.

“…The SARS‐CoV‐2 global pandemic will disproportionately impact countries with weak economies and vulnerable populations including people with dementia. Latin…”
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