Search Results - "Mehta, Sameet"

Genomic sites hypersensitive to ultraviolet radiation by Premi, Sanjay, Han, Lynn, Mehta, Sameet, Knight, James, Zhao, Dejian, Palmatier, Meg A., Kornacker, Karl, Brash, Douglas E.

“…If the genome contains outlier sequences extraordinarily sensitive to environmental agents, these would be sentinels for monitoring personal carcinogen…”
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HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin by Aygün, Ozan, Mehta, Sameet, Grewal, Shiv I S

“…The mechanisms underlying gene silencing and epigenetic stability of heterochromatin are not fully understood. New studies in fission yeast now show that…”
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Mtr4-like Protein Coordinates Nuclear RNA Processing for Heterochromatin Assembly and for Telomere Maintenance by Lee, Nathan N., Chalamcharla, Venkata R., Reyes-Turcu, Francisca, Mehta, Sameet, Zofall, Martin, Balachandran, Vanivilasini, Dhakshnamoorthy, Jothy, Taneja, Nitika, Yamanaka, Soichiro, Zhou, Ming, Grewal, Shiv I.S.

“…The regulation of protein-coding and noncoding RNAs is linked to nuclear processes, including chromatin modifications and gene silencing. However, the…”
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A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension by Gunawardhana, Kushan L, Hong, Lingjuan, Rugira, Trojan, Uebbing, Severin, Kucharczak, Joanna, Mehta, Sameet, Karunamuni, Dineth R, Cabera-Mendoza, Brenda, Gandotra, Neeru, Scharfe, Curt, Polimanti, Renato, Noonan, James P, Mani, Arya

“…Genetic variants in the third intron of the PRDM6 gene have been associated with BP traits in multiple GWAS. By combining fine mapping, massively parallel…”
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RNAi triggered by specialized machinery silences developmental genes and retrotransposons by Yamanaka, Soichiro, Mehta, Sameet, Reyes-Turcu, Francisca E., Zhuang, Fanglei, Fuchs, Ryan T., Rong, Yikang, Robb, Gregory B., Grewal, Shiv I. S.

“…In the fission yeast Schizosaccharomyces pombe RNA interference (RNAi) machinery promotes heterochromatin assembly and silencing of centromeric repeats; here…”
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Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV by Farhadian, Shelli F, Mehta, Sameet S, Zografou, Chrysoula, Robertson, Kevin, Price, Richard W, Pappalardo, Jenna, Chiarella, Jennifer, Hafler, David A, Spudich, Serena S

“…Central nervous system (CNS) immune activation is an important driver of neuronal injury during several neurodegenerative and neuroinflammatory diseases…”
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Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas by Zhang, Haifeng, Li, Busu, Huang, Qunhua, López-Giráldez, Francesc, Tanaka, Yoshiaki, Lin, Qun, Mehta, Sameet, Wang, Guilin, Graham, Morven, Liu, Xinran, Park, In-Hyun, Eichmann, Anne, Min, Wang, Zhou, Jenny Huanjiao

“…Although mitochondrial activity is critical for angiogenesis, its mechanism is not entirely clear. Here we show that mice with endothelial deficiency of any…”
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The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector by Tang, Xiaotian, Cao, Yongguo, Arora, Gunjan, Hwang, Jesse, Sajid, Andaleeb, Brown, Courtney L, Mehta, Sameet, Marín-López, Alejandro, Chuang, Yu-Min, Wu, Ming-Jie, Ma, Hongwei, Pal, Utpal, Narasimhan, Sukanya, Fikrig, Erol

“…Adiponectin-mediated pathways contribute to mammalian homeostasis; however, little is known about adiponectin and adiponectin receptor signaling in arthropods…”
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Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy by Boddupalli, Chandra Sekhar, Nair, Shiny, Belinsky, Glenn, Gans, Joseph, Teeple, Erin, Nguyen, Tri-Hung, Mehta, Sameet, Guo, Lilu, Kramer, Martin L, Ruan, Jiapeng, Wang, Honggge, Davison, Matthew, Kumar, Dinesh, Vidyadhara, D J, Zhang, Bailin, Klinger, Katherine, Mistry, Pramod K

“…Neuronopathic Gaucher disease (nGD) is a rare neurodegenerative disorder caused by biallelic mutations in and buildup of glycosphingolipids in lysosomes…”
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Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members by Gonzalo-Gil, Elena, Rapuano, Patrick B, Ikediobi, Uchenna, Leibowitz, Rebecca, Mehta, Sameet, Coskun, Ayse K, Porterfield, J Zachary, Lampkin, Teagan D, Marconi, Vincent C, Rimland, David, Walker, Bruce D, Deeks, Steven, Sutton, Richard E

“…HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131)…”
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Correction: The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector by Tang, Xiaotian, Cao, Yongguo, Arora, Gunjan, Hwang, Jesse, Sajid, Andaleeb, Brown, Courtney L, Mehta, Sameet, Marín-López, Alejandro, Chuang, Yu-Min, Wu, Ming-Jie, Ma, Hongwei, Pal, Utpal, Narasimhan, Sukanya, Fikrig, Erol

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MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3 by Joglekar, Mugdha V., Parekh, Vishal S., Mehta, Sameet, Bhonde, Ramesh R., Hardikar, Anandwardhan A.

“…The mammalian pancreas is known to show a remarkable degree of regenerative ability. Several studies until now have demonstrated that the mammalian pancreas…”
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Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice by Islam, Rafiad, White, Jordon D, Arefin, Tanzil M, Mehta, Sameet, Liu, Xinran, Polis, Baruh, Giuliano, Lauryn, Ahmed, Sahabuddin, Bowers, Christian, Zhang, Jiangyang, Kaffman, Arie

“…Early life adversity impairs hippocampal development and function across diverse species. While initial evidence indicated potential variations between males…”
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Prdm6 controls heart development by regulating neural crest cell differentiation and migration by Hong, Lingjuan, Li, Na, Gasque, Victor, Mehta, Sameet, Ye, Lupeng, Wu, Yinyu, Li, Jinyu, Gewies, Andreas, Ruland, Jürgen, Hirschi, Karen K, Eichmann, Anne, Hendry, Caroline, van Dijk, David, Mani, Arya

“…The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates is still poorly understood. Here, we identified Prdm6 as an…”
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Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis by Arterbery, Adam S, Yao, Jie, Ling, Andrew, Avitzur, Yaron, Martinez, Mercedes, Lobritto, Steven, Deng, Yanhong, Geliang, Gan, Mehta, Sameet, Wang, Guilin, Knight, James, Ekong, Udeme D

“…autoimmune hepatitis (DAIH) is an important cause of late allograft dysfunction following liver transplantation, but its cause and underlying pathogenesis…”
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Endothelial cell-glucocorticoid receptor interactions and regulation of Wnt signaling by Zhou, Han, Mehta, Sameet, Srivastava, Swayam Prakash, Grabinska, Kariona, Zhang, Xinbo, Wong, Chris, Hedayat, Ahmad, Perrotta, Paola, Fernández-Hernando, Carlos, Sessa, William C, Goodwin, Julie E

“…Vascular inflammation is present in many cardiovascular diseases, and exogenous glucocorticoids have traditionally been used as a therapy to suppress…”
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MicroRNA-1 protects the endothelium in acute lung injury by Korde, Asawari, Haslip, Maria, Pednekar, Prachi, Khan, Alamzeb, Chioccioli, Maurizio, Mehta, Sameet, Lopez-Giraldez, Francesc, Bermejo, Santos, Rojas, Mauricio, Dela Cruz, Charles, Matthay, Michael A, Pober, Jordan S, Pierce, Richard W, Takyar, Shervin S

“…Acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), cause severe endothelial dysfunction in the lung, and vascular…”
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Changes in bone marrow innate lymphoid cell subsets in monoclonal gammopathy: target for IMiD therapy by Kini Bailur, Jithendra, Mehta, Sameet, Zhang, Lin, Neparidze, Natalia, Parker, Terri, Bar, Noffar, Anderson, Tara, Xu, Mina L., Dhodapkar, Kavita M., Dhodapkar, Madhav V.

“…•Altered number, subset composition, and function of bone marrow innate lymphoid cells are early events in monoclonal gammopathies.•Pomalidomide therapy leads…”
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Early cellular and molecular signatures correlate with severity of West Nile virus infection by Lee, Ho-Joon, Zhao, Yujiao, Fleming, Ira, Mehta, Sameet, Wang, Xiaomei, Wyk, Brent Vander, Ronca, Shannon E., Kang, Heather, Chou, Chih-Hung, Fatou, Benoit, Smolen, Kinga K., Levy, Ofer, Clish, Clary B., Xavier, Ramnik J., Steen, Hanno, Hafler, David A., Love, J. Christopher, Shalek, Alex K., Guan, Leying, Murray, Kristy O., Kleinstein, Steven H., Montgomery, Ruth R.

“…Infection with West Nile virus (WNV) drives a wide range of responses, from asymptomatic to flu-like symptoms/fever or severe cases of encephalitis and death…”
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Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira by Adhikarla, Haritha, Wunder, Jr, Elsio A, Mechaly, Ariel E, Mehta, Sameet, Wang, Zheng, Santos, Luciane, Bisht, Vimla, Diggle, Peter, Murray, Gerald, Adler, Ben, Lopez, Francesc, Townsend, Jeffrey P, Groisman, Eduardo, Picardeau, Mathieu, Buschiazzo, Alejandro, Ko, Albert I

“…Leptospirosis is an emerging zoonotic disease with more than 1 million cases annually. Currently there is lack of evidence for signaling pathways involved…”
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