Search Results - "Mehta, A. M."

Distinct frontal systems for response inhibition, attentional capture, and error processing by Sharp, D. J., Bonnelle, V., De Boissezon, X., Beckmann, C. F., James, S. G., Patel, M. C., Mehta, M. A., Smith, Edward E.

“…Stopping an action in response to an unexpected event requires both that the event is attended to, and that the action is inhibited. Previous neuroimaging…”
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Ketamine induces a robust whole-brain connectivity pattern that can be differentially modulated by drugs of different mechanism and clinical profile by Joules, R., Doyle, O. M., Schwarz, A. J., O’Daly, O. G., Brammer, M., Williams, S. C., Mehta, M. A.

“…Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, has been studied in relation to the glutamate hypothesis of schizophrenia and increases…”
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Profiles of objective and subjective cognitive function in Post-COVID Syndrome, COVID-19 recovered, and COVID-19 naïve individuals by Bland, A. R., Barraclough, M., Trender, W. R., Mehta, M. A., Hellyer, P. J., Hampshire, A., Penner, I. K., Elliott, R., Harenwall, S.

“…Post-COVID Syndrome has emerged as a significant public health concern worldwide with increasing evidence to suggest that individuals who have had an acute…”
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The effect of ketamine and D-cycloserine on the high frequency resting EEG spectrum in humans by Nottage, J. F., Gabay, A., De Meyer, K., Herrik, K. F., Bastlund, J. F., Christensen, S. R., Gijsen, S., Mehta, M. A.

“…Rationale Preclinical studies indicate that high-frequency oscillations, above 100 Hz (HFO:100–170 Hz), are a potential translatable biomarker for…”
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Cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy improves survival in patients with colorectal peritoneal metastases compared with systemic chemotherapy alone by Mirnezami, R, Mehta, A M, Chandrakumaran, K, Cecil, T, Moran, B J, Carr, N, Verwaal, V J, Mohamed, F, Mirnezami, A H

“…Background: Colorectal cancer peritoneal metastasis (CPM) confers an exceptionally poor prognosis, and traditional treatment involving systemic chemotherapy…”
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Test–retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers by De Simoni, S., Schwarz, A.J., O'Daly, O.G., Marquand, A.F., Brittain, C., Gonzales, C., Stephenson, S., Williams, S.C.R., Mehta, M.A.

“…The pharmacological MRI (phMRI) technique is being increasingly used in both pre-clinical and clinical models to investigate pharmacological effects on…”
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Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology by Stone, J M, Dietrich, C, Edden, R, Mehta, M A, De Simoni, S, Reed, L J, Krystal, J H, Nutt, D, Barker, G J

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Dopamine manipulations modulate paranoid social inferences in healthy people by Barnby, J. M., Bell, V., Deeley, Q., Mehta, M. A.

“…Altered dopamine transmission is thought to influence the formation of persecutory delusions. However, despite extensive evidence from clinical studies there…”
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The impact of CFTR modulator triple therapy on type 2 inflammatory response in patients with cystic fibrosis by Mehta, A M, Lee, I, Li, G, Jones, M K, Hanson, L, Lonabaugh, K, List, R, Borish, L, Albon, D P

“…Treatment of cystic fibrosis (CF) has been revolutionized by the use of cystic fibrosis transmembrane conductance regulator (CFTR) protein modulators such as…”
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Prefrontal cortex dopamine release measured in vivo with positron emission tomography: Implications for the stimulant paradigm by Hernaus, D., Mehta, M.A.

“…Experimental tasks and stimulant paradigms in combination with D2/3 emission tomography have been essential in understanding the dopamine (DA) system. However,…”
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Effects of ketamine on brain function during response inhibition by Steffens, M., Neumann, C., Kasparbauer, A.-M., Becker, B., Weber, B., Mehta, M. A., Hurlemann, R., Ettinger, U.

“…Introduction The uncompetitive N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonist ketamine has been proposed to model symptoms of psychosis. Inhibitory…”
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D2/D3 dopamine supports the precision of mental state inferences and self-relevance of joint social outcomes by Barnby, J M, Bell, V, Deeley, Q, Mehta, M A, Moutoussis, M

“…Striatal dopamine is important in paranoid attributions, although its computational role in social inference remains elusive. We employed a simple…”
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Multivariate decoding of brain images using ordinal regression by Doyle, O.M., Ashburner, J., Zelaya, F.O., Williams, S.C.R., Mehta, M.A., Marquand, A.F.

“…Neuroimaging data are increasingly being used to predict potential outcomes or groupings, such as clinical severity, drug dose response, and transitional…”
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Perioperative systemic chemotherapy in peritoneal carcinomatosis of lymph node positive colorectal cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy by Kuijpers, A.M., Mehta, A.M., Boot, H., van Leerdam, M.E., Hauptmann, M., Aalbers, A.G., Verwaal, V.J.

“…Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is the preferred treatment of peritoneal carcinomatosis (PC) of colorectal…”
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Neuropsychological predictors of clinical outcome in opiate addiction by Passetti, F, Clark, L, Mehta, M.A, Joyce, E, King, M

“…Abstract A growing literature supports a role for neurocognitive deficits such as impaired decision-making in the development and maintenance of addictive…”
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Paranoia, sensitization and social inference: findings from two large-scale, multi-round behavioural experiments by Barnby, J M, Deeley, Q, Robinson, O, Raihani, N, Bell, V, Mehta, M A

“…The sensitization model suggests that paranoia is explained by over-sensitivity to social threat. However, this has been difficult to test experimentally. We…”
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Phenomenologically distinct psychotomimetic effects of ketamine are associated with cerebral blood flow changes in functionally relevant cerebral foci: a continuous arterial spin labelling study by Pollak, T. A., De Simoni, S., Barimani, B., Zelaya, F. O., Stone, J. M., Mehta, M. A.

“…Rationale The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine provides a pragmatic approach to address the link between glutamate-mediated changes in…”
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Disorder-specific grey matter deficits in attention deficit hyperactivity disorder relative to autism spectrum disorder by Lim, L, Chantiluke, K, Cubillo, A I, Smith, A B, Simmons, A, Mehta, M A, Rubia, K

“…Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two common childhood disorders that exhibit genetic and behavioural…”
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Effects of ketamine on brain function during smooth pursuit eye movements by Steffens, M., Becker, B., Neumann, C., Kasparbauer, A.M., Meyhöfer, I., Weber, B., Mehta, M.A., Hurlemann, R., Ettinger, U.

“…The uncompetitive NMDA receptor antagonist ketamine has been proposed to model symptoms of psychosis. Smooth pursuit eye movements (SPEM) are an established…”
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Risky decision-making predicts short-term outcome of community but not residential treatment for opiate addiction. Implications for case management by Passetti, F, Clark, L, Davis, P, Mehta, M.A, White, S, Checinski, K, King, M, Abou-Saleh, M

“…Abstract Background Opiate addiction is associated with decision-making deficits and we previously showed that the extent of these impairments predicts aspects…”
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