Search Results - "Mehrotra, Prachi"
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Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion
Published in Cell reports (Cambridge) (18-02-2020)“…The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high…”
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Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques
Published in iScience (15-12-2023)“…The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates viral immune sensing, and induces…”
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Clustering of multi‐domain protein sequences
Published in Proteins, structure, function, and bioinformatics (01-07-2018)“…The overall function of a multi‐domain protein is determined by the functional and structural interplay of its constituent domains. Traditional sequence…”
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Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD
Published in Clinical immunology (Orlando, Fla.) (01-10-2023)“…Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract…”
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Comparison of Leptospira interrogans and Leptospira biflexa genomes: analysis of potential leptospiral-host interactions
Published in Molecular bioSystems (02-05-2017)“…Leptospirosis, a potentially life-threatening disease, remains the most widespread zoonosis caused by pathogenic species of Leptospira. The pathogenic…”
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CLAP: a web-server for automatic classification of proteins with special reference to multi-domain proteins
Published in BMC bioinformatics (04-10-2014)“…The function of a protein can be deciphered with higher accuracy from its structure than from its amino acid sequence. Due to the huge gap in the available…”
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Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIV mac239 in rhesus macaques
Published in iScience (15-12-2023)“…The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates viral immune sensing, and induces…”
Get full text
Journal Article -
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The relationship between classification of multi-domain proteins using an alignment-free approach and their functions: a case study with immunoglobulins
Published in Molecular bioSystems (01-01-2014)“…Establishing functional relationships between multi-domain protein sequences is a non-trivial task. Traditionally, delineating functional assignment and…”
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168 Classification of protein sequences with special references to multi-domain systems
Published in Journal of biomolecular structure & dynamics (18-05-2015)Get full text
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