Search Results - "Mehrnaz Gharaee-Kermani"

Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin by Hile, Grace A., Coit, Patrick, Xu, Bin, Victory, Amanda M., Gharaee‐Kermani, Mehrnaz, Estadt, Shannon N., Maz, Mitra P., Martens, Jacob W. S., Wasikowski, Rachael, Dobry, Craig, Tsoi, Lam C., Iglesias‐Bartolome, Ramiro, Berthier, Celine C., Billi, Allison C., Gudjonsson, Johann E., Sawalha, Amr H., Kahlenberg, J. Michelle

“…Objective Photosensitivity is one of the most common manifestations of systemic lupus erythematosus (SLE), yet its pathogenesis is not well understood. The…”
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The IL-4/IL-13 signaling axis promotes prostatic fibrosis by D'Arcy, Quentin, Gharaee-Kermani, Mehrnaz, Zhilin-Roth, Alisa, Macoska, Jill A

“…Background Lower urinary tract symptoms (LUTS) are a costly and pervasive medical problem for millions of aging men. Recent studies have showed that…”
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The IL-4/IL-13 signaling axis promotes prostatic fibrosis by Quentin D'Arcy, Mehrnaz Gharaee-Kermani, Alisa Zhilin-Roth, Jill A Macoska

“…BackgroundLower urinary tract symptoms (LUTS) are a costly and pervasive medical problem for millions of aging men. Recent studies have showed that…”
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Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis by Ma, Feiyang, Plazyo, Olesya, Billi, Allison C., Tsoi, Lam C., Xing, Xianying, Wasikowski, Rachael, Gharaee-Kermani, Mehrnaz, Hile, Grace, Jiang, Yanyun, Harms, Paul W., Xing, Enze, Kirma, Joseph, Xi, Jingyue, Hsu, Jer-En, Sarkar, Mrinal K., Chung, Yutein, Di Domizio, Jeremy, Gilliet, Michel, Ward, Nicole L., Maverakis, Emanual, Klechevsky, Eynav, Voorhees, John J., Elder, James T., Lee, Jun Hee, Kahlenberg, J. Michelle, Pellegrini, Matteo, Modlin, Robert L., Gudjonsson, Johann E.

“…The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of…”
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Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation by Billi, Allison C, Ma, Feiyang, Plazyo, Olesya, Gharaee-Kermani, Mehrnaz, Wasikowski, Rachael, Hile, Grace A, Xing, Xianying, Yee, Christine M, Rizvi, Syed M, Maz, Mitra P, Berthier, Celine C, Wen, Fei, Tsoi, Lam C, Pellegrini, Matteo, Modlin, Robert L, Gudjonsson, Johann E, Kahlenberg, J Michelle

“…Cutaneous lupus erythematosus (CLE) is a disfiguring and poorly understood condition frequently associated with systemic lupus. Previous studies suggest that…”
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Epigenetic Regulation of Myofibroblast Differentiation by DNA Methylation by Hu, Biao, Gharaee-Kermani, Mehrnaz, Wu, Zhe, Phan, Sem H

“…DNA methylation, a key mechanism of repressing gene expression, is of particular relevance in controlling development and cell differentiation. We analyzed the…”
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Essential Role of MeCP2 in the Regulation of Myofibroblast Differentiation during Pulmonary Fibrosis by Hu, Biao, Gharaee-Kermani, Mehrnaz, Wu, Zhe, Phan, Sem H

“…DNA methylation is a key mechanism for repression of gene expression, including that of α-smooth muscle actin (α-SMA) gene expression in fibroblasts. However,…”
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Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion by Gharaee-Kermani, Mehrnaz, Moore, Bethany B, Macoska, Jill A

“…Resveratrol, a phytoalexin found in berries, peanuts, grapes, and red wine, inhibits oxidation, inflammation, and cell proliferation and collagen synthesis in…”
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Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis by Ma, Feiyang, Tsou, Pei-Suen, Gharaee-Kermani, Mehrnaz, Plazyo, Olesya, Xing, Xianying, Kirma, Joseph, Wasikowski, Rachael, Hile, Grace A., Harms, Paul W., Jiang, Yanyun, Xing, Enze, Nakamura, Mio, Ochocki, Danielle, Brodie, William D., Pillai, Shiv, Maverakis, Emanual, Pellegrini, Matteo, Modlin, Robert L., Varga, John, Tsoi, Lam C., Lafyatis, Robert, Kahlenberg, J. Michelle, Billi, Allison C., Khanna, Dinesh, Gudjonsson, Johann E.

“…Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to…”
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CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis by Gharaee-Kermani, Mehrnaz, Kasina, Sathish, Moore, Bethany B, Thomas, Dafydd, Mehra, Rohit, Macoska, Jill A

“…Recent studies from our group suggest that extracellular matrix (ECM) deposition and fibrosis characterize the peri-urethral prostate tissues of some men…”
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Loss of interleukin-1 beta is not protective in the lupus-prone NZM2328 mouse model by Loftus, Shannon N, Liu, Jianhua, Berthier, Celine C, Gudjonsson, Johann E, Gharaee-Kermani, Mehrnaz, Tsoi, Lam C, Kahlenberg, J Michelle

“…Aberrant activation of the innate immune system is a known driver of lupus pathogenesis. Inhibition of the inflammasome and its downstream signaling components…”
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Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1 by Loftus, Shannon N, Gharaee-Kermani, Mehrnaz, Xu, Bin, Moore, Tyson M, Hannoudi, Andrew, Mallbris, Mischa J, Klein, Benjamin, Gudjonsson, Johann E, Kahlenberg, J Michelle

“…Ultraviolet (UV) light is a known trigger of both cutaneous and systemic disease manifestations in lupus patients. Lupus skin has elevated expression of type I…”
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Obesity-induced diabetes and lower urinary tract fibrosis promote urinary voiding dysfunction in a mouse model by Gharaee-Kermani, Mehrnaz, Rodriguez-Nieves, Jose A., Mehra, Rohit, Vezina, Chad A., Sarma, Aruna V., Macoska, Jill A.

“…BACKGROUND Progressive aging‐ and inflammation‐associated fibrosis effectively remodels the extracellular matrix (ECM) to increase prostate tissue stiffness…”
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CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling by Rodríguez-Nieves, José A, Patalano, Susan C, Almanza, Diego, Gharaee-Kermani, Mehrnaz, Macoska, Jill A

“…Benign prostate hyperplasia (BPH), an enlargement of the prostate common in aging in men, is associated with urinary voiding dysfunction manifest as Lower…”
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401 Single-cell RNA sequencing reveals cellular drivers of UV-mediated skin injury in cutaneous lupus by Maz, Mitra P, Ma, Feiyang, Gharaee-Kermani, Mehrnaz, Victory, Amanda M, Hurst, Amy, Gudjonsson, Johann, Michelle Kahlenberg, J

“…BackgroundUltraviolet light (UV) is a known trigger of cutaneous lupus erythematosus (CLE) flares in systemic lupus erythematosus (SLE) patients, yet cell…”
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New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis : A potential role for stem cells in the lung parenchyma and implications for therapy by GHARAEE-KERMANI, Mehrnaz, GYETKO, Margaret R, BIAO HU, PHAN, Sem H

“…Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and often fatal form of interstitial lung disease. It is characterized by injury with loss of…”
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IL18-containing 5-gene signature distinguishes histologically identical dermatomyositis and lupus erythematosus skin lesions by Tsoi, Lam C, Gharaee-Kermani, Mehrnaz, Berthier, Celine C, Nault, Tori, Hile, Grace A, Estadt, Shannon N, Patrick, Matthew T, Wasikowski, Rachael, Billi, Allison C, Lowe, Lori, Reed, Tamra J, Gudjonsson, Johann E, Kahlenberg, J Michelle

“…Skin lesions in dermatomyositis (DM) are common, are frequently refractory, and have prognostic significance. Histologically, DM lesions appear similar to…”
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The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity by Billi, Allison C, Gharaee-Kermani, Mehrnaz, Fullmer, Joseph, Tsoi, Lam C, Hill, Brett D, Gruszka, Dennis, Ludwig, Jessica, Xing, Xianying, Estadt, Shannon, Wolf, Sonya J, Rizvi, Syed Monem, Berthier, Celine C, Hodgin, Jeffrey B, Beamer, Maria A, Sarkar, Mrinal K, Liang, Yun, Uppala, Ranjitha, Shao, Shuai, Zeng, Chang, Harms, Paul W, Verhaegen, Monique E, Voorhees, John J, Wen, Fei, Ward, Nicole L, Dlugosz, Andrzej A, Kahlenberg, J Michelle, Gudjonsson, Johann E

“…Autoimmune disease is 4 times more common in women than men. This bias is largely unexplained. Female skin is "autoimmunity prone," showing upregulation of…”
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HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling by Uppala, Ranjitha, Sarkar, Mrinal K., Young, Kelly Z., Ma, Feiyang, Vemulapalli, Pritika, Wasikowski, Rachael, Plazyo, Olesya, Swindell, William R., Maverakis, Emanual, Gharaee-Kermani, Mehrnaz, Billi, Allison C., Tsoi, Lam C., Kahlenberg, J. Michelle, Gudjonsson, Johann E.

“…Interferon (IFN) activity exhibits a gender bias in human skin, skewed toward females. We show that HERC6, an IFN-induced E3 ubiquitin ligase, is induced in…”
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Pansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis by Xing, Enze, Ma, Feiyang, Wasikowski, Rachael, Billi, Allison C, Gharaee-Kermani, Mehrnaz, Fox, Jennifer, Dobry, Craig, Victory, Amanda, Sarkar, Mrinal K, Xing, Xianying, Plazyo, Olesya, Chen, Henry W, Barber, Grant, Jacobe, Heidi, Tsou, Pei-Suen, Modlin, Robert L, Varga, John, Kahlenberg, J Michelle, Tsoi, Lam C, Gudjonsson, Johann E, Khanna, Dinesh

“…Pansclerotic morphea (PSM) is a rare, devastating disease characterized by extensive soft tissue fibrosis, secondary contractions, and significant morbidity…”
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